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  • Edgren, GustafKarolinska Institutet (author)

Transmission of Neurodegenerative Disorders Through Blood Transfusion A Cohort Study

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2016
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-304152
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-304152URI
  • https://doi.org/10.7326/M15-2421DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:134099094URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: The aggregation of misfolded proteins in the brain occurs in several neurodegenerative disorders. Aberrant protein aggregation is inducible in rodents and primates by intracerebral inoculation. Possible transfusion transmission of neurodegenerative diseases has important public health implications. Objective: To investigate possible transfusion transmission of neurodegenerative disorders. Design: Retrospective cohort study. Setting: Nationwide registers of transfusions in Sweden and Denmark. Participants: 1 465 845 patients who received transfusions between 1968 and 2012. Measurements: Multivariable Cox regression models were used to estimate hazard ratios for dementia of any type, Alzheimer disease, and Parkinson disease in patients receiving blood transfusions from donors who were later diagnosed with any of these diseases versus patients who received blood from healthy donors. Whether excess occurrence of neurodegenerative disease occurred among recipients of blood from a subset of donors was also investigated. As a positive control, transmission of chronic hepatitis before and after implementation of hepatitis C virus screening was assessed. Results: Among included patients, 2.9% received a transfusion from a donor diagnosed with one of the studied neurodegenerative diseases. No evidence of transmission of any of these diseases was found, regardless of approach. The hazard ratio for dementia in recipients of blood from donors with dementia versus recipients of blood from healthy donors was 1.04 (95% CI, 0.99 to 1.09). Corresponding estimates for Alzheimer disease and Parkinson disease were 0.99 (CI, 0.85 to 1.15) and 0.94 (CI, 0.78 to 1.14), respectively. Hepatitis transmission was detected before but not after implementation of hepatitis C virus screening. Limitation: Observational study design, underascertainment of the outcome, and possible insufficient statistical power. Conclusion: The data provide no evidence for the transmission of neurodegenerative diseases and suggest that if transmission does occur, it is rare.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Hjalgrim, HenrikStatens Serum Inst, Dept Epidemiol Res, 5 Artillerivej, DK-2300 Copenhagen S, Denmark. (author)
  • Rostgaard, KlausStatens Serum Inst, Dept Epidemiol Res, 5 Artillerivej, DK-2300 Copenhagen S, Denmark. (author)
  • Lambert, PaulKarolinska Institutet (author)
  • Wikman, AgnetaKarolinska Institutet (author)
  • Norda, RutUppsala universitet,Klinisk immunologi(Swepub:uu)runor498 (author)
  • Titlestad, Kjell-EinarOdense Univ Hosp, Dept Clin Immunol, Sondre Blvd 29, DK-5000 Odense, Denmark. (author)
  • Erikstrup, ChristianAarhus Univ Hosp, Dept Clin Immunol, Palle Juul Jensens Blvd 99, DK-8000 Aarhus, Denmark. Stanford Univ, Sch Med, Stanford, CA 94305 USA. (author)
  • Ullum, HenrikCopenhagen Univ Hosp, Dept Clin Immunol, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. (author)
  • Melbye, MadsStatens Serum Inst, Dept Epidemiol Res, 5 Artillerivej, DK-2300 Copenhagen S, Denmark. (author)
  • Busch, Michael P.Blood Syst Res Inst, 270 Masonic Ave, San Francisco, CA 94118 USA. Univ Calif San Francisco, San Francisco, CA USA. (author)
  • Nyren, OlofKarolinska Inst, Dept Med Epidemiol & Biostat, Box 281, SE-17177 Stockholm, Sweden. (author)
  • Karolinska InstitutetStatens Serum Inst, Dept Epidemiol Res, 5 Artillerivej, DK-2300 Copenhagen S, Denmark. (creator_code:org_t)

Related titles

  • In:Annals of Internal Medicine165:5, s. 316-+0003-48191539-3704

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