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Albuminuria and car...
Albuminuria and cardiovascular events in patients with acute coronary syndromes : Results from the TRACER trial
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- Åkerblom, Axel (author)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Duke Clin Res Inst, Durham, NC USA.
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- Clare, Robert M. (author)
- Duke Clin Res Inst, Durham, NC USA.
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- Lokhnygina, Yuliya (author)
- Duke Clin Res Inst, Durham, NC USA.
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- Wallentin, Lars (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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- Held, Claes (author)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Van de Werf, Frans (author)
- Univ Leuven, Dept Cardiol, Leuven, Sweden.
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- Moliterno, David J. (author)
- Univ Kentucky, Gill Heart Inst, Lexington, KY USA.;Univ Kentucky, Div Cardiovasc Med, Lexington, KY USA.
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- Patel, Uptal D. (author)
- Duke Clin Res Inst, Durham, NC USA.
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- Leonardi, Sergio (author)
- Fdn IRCCS Policlin San Matteo, Pavia, Italy.
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- Armstrong, Paul W. (author)
- Univ Alberta, Div Cardiol, Edmonton, AB, Canada.
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- Harrington, Robert A. (author)
- Stanford Univ, Dept Med, Stanford, CA 94305 USA.
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- White, Harvey D. (author)
- Auckland City Hosp, Green Lane Cardiovasc Serv, Auckland, New Zealand.
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- Aylward, Philip E. (author)
- Flinders Univ & Med Ctr, South Australian Hlth & Med Res Inst, Adelaide, SA, Australia.
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- Mahaffey, Kenneth W. (author)
- Stanford Univ, Dept Med, Stanford, CA 94305 USA.
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- Tricoci, Pierluigi (author)
- Duke Clin Res Inst, Durham, NC USA.
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
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In: American Heart Journal. - : Elsevier BV. - 0002-8703 .- 1097-6744. ; 178, s. 1-8
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background Albuminuria is associated with cardiovascular (CV) outcomes. We evaluated albuminuria, alone and in combination with estimated glomerular filtration rate (eGFR), as a predictor of mortality and CV morbidity in 12,944 patients with non-ST-segment elevation acute coronary syndromes. Methods Baseline serum creatinine and urinary dipsticks were obtained, with albuminuria stratified into no/trace albuminuria, microalbuminuria (>= 30 but <300 mg/dL), or macroalbuminuria (>= 300 mg/dL). Kaplan-Meier rates and proportional Cox hazards models of CV death, overall mortality, CV death or myocardial infarction (MI), and bleeding were calculated. Incidence of acute kidney injury, identified by adverse event reporting and creatinine increase (absolute >= 0.3 mg/dL or relative >= 50%), was descriptively reported. Results Both dipstick albuminuria and creatinine values were available in 9473 patients (73.2%). More patients with macroalbuminuria, versus no/trace albuminuria, had diabetes (66% vs 27%) or hypertension (86% vs 68%). Rates for CV death and overall mortality per strata were 3.1% and 4.8% (no/trace albuminuria); 5.8% and 9.0% (microalbuminuria); and 7.7% and 12.6% (macroalbuminuria) at 2 years of follow-up. Corresponding rates for CV death or MI were 12.2%, 16.9%, and 23.5%, respectively. Observed acute kidney injury rates were 0.6%, 1.2%, and 2.9% (n = 79), respectively. Adjusted HRs for macroalbuminuria on CV mortality were 1.65 (95% CI 1.15-2.37), and after adjustment with eGFR, 1.37 (95% CI 0.93-2.01). Corresponding HRs for overall mortality were 1.82 (95% CI 1.37-2.42) and 1.47 (95% CI 1.08-1.98). Conclusions High-risk patients with non-ST-segment elevation acute coronary syndromes and albuminuria have increased morbidity and increased overall mortality independent of eGFR.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Åkerblom, Axel
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Clare, Robert M.
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Lokhnygina, Yuli ...
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Wallentin, Lars
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Held, Claes
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Van de Werf, Fra ...
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Moliterno, David ...
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Patel, Uptal D.
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Leonardi, Sergio
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Armstrong, Paul ...
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Harrington, Robe ...
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White, Harvey D.
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Aylward, Philip ...
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Mahaffey, Kennet ...
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Tricoci, Pierlui ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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American Heart J ...
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Uppsala University