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Genetic determinant...
Genetic determinants of warfarin maintenance dose and time in therapeutic treatment range : a RE-LY genomics substudy
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- Eriksson, Niclas (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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- Wallentin, Lars (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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- Berglund, Lars (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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- Axelsson, Tomas (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab
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- Connolly, Stuart (author)
- Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada.;McMaster Univ, Hamilton, ON, Canada.
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- Eikelboom, John (author)
- Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada.;McMaster Univ, Hamilton, ON, Canada.
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- Ezekowitz, Michael (author)
- Thomas Jefferson Univ, Sidney Kimmel Med Collage, Philadelphia, PA 19107 USA.
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- Oldgren, Jonas (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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- Pare, Guillaume (author)
- Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada.;McMaster Univ, Hamilton, ON, Canada.
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- Reilly, Paul (author)
- Boehringer Ingelheim Pharma Inc, Ridgefield, CT USA.
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- Siegbahn, Agneta (author)
- Uppsala universitet,Koagulation och inflammationsvetenskap,Science for Life Laboratory, SciLifeLab
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- Syvänen, Ann-Christine (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär medicin
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- Wadelius, Claes (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik
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- Yusuf, Salim (author)
- Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada.;McMaster Univ, Hamilton, ON, Canada.
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- Wadelius, Mia (author)
- Uppsala universitet,Klinisk farmakogenomik och osteoporos,Science for Life Laboratory, SciLifeLab
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(creator_code:org_t)
- Future Medicine Ltd, 2016
- 2016
- English.
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In: Pharmacogenomics (London). - : Future Medicine Ltd. - 1462-2416 .- 1744-8042. ; 17:13, s. 1425-1439
- Related links:
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https://uu.diva-port... (primary) (Raw object)
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https://www.futureme...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Subject headings
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- Aims: We investigated associations between genetic variation in candidate genes and on a genome-wide scale with warfarin maintenance dose, time in therapeutic range (TTR), and risk of major bleeding. Materials & methods: In total, 982 warfarin-treated patients from the RE-LY trial were studied. Results: After adjusting for SNPs in VKORC1 and CYP2C9, SNPs in DDHD1 (rs17126068) and NEDD4 (rs2288344) were associated with dose. Adding these SNPs and CYP4F2 (rs2108622) to a base model increased R-2 by 2.9%. An SNP in ASPH (rs4379440) was associated with TTR (-6.8% per minor allele). VKORC1 was associated with time less than INR 2.0. VKORC1 and CYP2C9 were associated with time more than INR 3.0, but not with major bleeding. Conclusions: We identified two novel genes associated with warfarin maintenance dose and one gene associated with TTR. These genes need to be replicated in an independent cohort.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- CYP2C9
- CYP4F2
- genome-wide association study
- prediction models
- time in therapeutic range
- VKORC1
- warfarin
- warfarin dose
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Eriksson, Niclas
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Wallentin, Lars
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Berglund, Lars
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Axelsson, Tomas
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Connolly, Stuart
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Eikelboom, John
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show more...
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Ezekowitz, Micha ...
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Oldgren, Jonas
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Pare, Guillaume
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Reilly, Paul
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Siegbahn, Agneta
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Syvänen, Ann-Chr ...
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Wadelius, Claes
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Yusuf, Salim
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Wadelius, Mia
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmacology and ...
- Articles in the publication
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Pharmacogenomics ...
- By the university
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Uppsala University