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High Maternal Body ...
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Lindam, AnnaKarolinska Inst, Stockholm, Sweden.
(author)
High Maternal Body Mass Index in Early Pregnancy and Risks of Stillbirth and Infant Mortality-A Population-Based Sibling Study in Sweden
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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2016-06-29
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Oxford University Press (OUP),2016
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-305945
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-305945URI
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https://doi.org/10.1093/aje/kww046DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:134264328URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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In a population-based case-control study, we investigated whether familial confounding influenced the associations between maternal overweight/obesity and risks of stillbirth and infant mortality by including both population and sister controls. Using nationwide data from the Swedish Medical Birth Register (1992-2011), we included all primiparous women with singleton births who also had a sister with a first birth during that time period. We used logistic regression analyses to calculate odds ratios (and 95% confidence intervals) adjusted for maternal age, height, smoking habits, education, and time period (5-year groups) of child's birth. Body mass index (BMI) was calculated as weight (kg)/height (m)(2). Compared with population controls with a normal BMI (18.5-24.9), stillbirth risk increased with increasing BMI (BMI 25-29.9: odds ratio (OR) = 1.51 (95% confidence interval (CI): 1.21, 1.89); BMI 30-34.9: OR = 1.77 (95% CI: 1.24, 2.50); BMI a parts per thousand yen35: OR = 3.16 (95% CI: 2.10, 4.76)). The sister case-control analyses revealed similar results. Offspring of obese women (BMI a parts per thousand yen30) had an increased risk of infant mortality when population controls were used (OR = 2.41, 95% CI: 1.83, 3.16), and an even higher risk was obtained when sister controls were used (OR = 4.04, 95% CI: 2.25, 7.25). We conclude that obesity in early pregnancy is associated with increased risks of stillbirth and infant mortality independently of genetic and early environmental risk factors shared within families.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Johansson, StefanKarolinska Institutet
(author)
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Stephansson, OlofKarolinska Institutet
(author)
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Wikström, Anna-KarinKarolinska Institutet,Uppsala universitet,Obstetrik & gynekologi,Karolinska Inst, Stockholm, Sweden.(Swepub:uu)annwi179
(author)
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Cnattingius, SvenKarolinska Institutet
(author)
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Karolinska InstitutetKarolinska Inst, Stockholm, Sweden.
(creator_code:org_t)
Related titles
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In:American Journal of Epidemiology: Oxford University Press (OUP)184:2, s. 98-1050002-92621476-6256
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