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Using the Disease S...
Using the Disease State Fingerprint Tool for Differential Diagnosis of Frontotemporal Dementia and Alzheimer's Disease
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- Munoz-Ruiz, Miguel Angel (author)
- Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland.
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- Hall, Anette (author)
- Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland.
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- Mattila, Jussi (author)
- VTT Tech Res Ctr Finland, Tampere, Finland.
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- Koikkalainen, Juha (author)
- VTT Tech Res Ctr Finland, Tampere, Finland.
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- Herukka, Sanna-Kaisa (author)
- Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Dept Neurol, Kuopio, Finland.
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- Husso, Minna (author)
- Kuopio Univ Hosp, Dept Radiol, Kuopio, Finland.
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- Hanninen, Tuomo (author)
- Kuopio Univ Hosp, Dept Neurol, Kuopio, Finland.
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- Vanninen, Ritva (author)
- Kuopio Univ Hosp, Dept Radiol, Kuopio, Finland.
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- Liu, Yawu (author)
- Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Dept Radiol, Kuopio, Finland.
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- Hallikainen, Merja (author)
- Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland.
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- Lotjonen, Jyrki (author)
- VTT Tech Res Ctr Finland, Tampere, Finland.
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- Remes, Anne M. (author)
- Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Dept Neurol, Kuopio, Finland.
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- Alafuzoff, Irina (author)
- Uppsala universitet,Experimentell och klinisk onkologi,Univ Uppsala Hosp, Rudbeck Lab, Dept Clin Surg Pathol, Uppsala, Sweden.
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- Soininen, Hilkka (author)
- Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Dept Neurol, Kuopio, Finland.
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- Hartikainen, Paivi (author)
- Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Dept Neurol, Kuopio, Finland.
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Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland VTT Tech Res Ctr Finland, Tampere, Finland. (creator_code:org_t)
- 2016-07-22
- 2016
- English.
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In: Dementia and Geriatric Cognitive Disorders Extra. - : S. Karger AG. - 1664-5464. ; 6:2, s. 313-329
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: Disease State Index (DSI) and its visualization, Disease State Fingerprint (DSF), form a computer-assisted clinical decision making tool that combines patient data and compares them with cases with known outcomes. Aims: To investigate the ability of the DSI to diagnose frontotemporal dementia (FTD) and Alzheimer's disease (AD). Methods: The study cohort consisted of 38 patients with FTD, 57 with AD and 22 controls. Autopsy verification of FTD with TDP-43 positive pathology was available for 14 and AD pathology for 12 cases. We utilized data from neuropsychological tests, volumetric magnetic resonance imaging, single-photon emission tomography, cerebrospinal fluid biomarkers and the APOE genotype. The DSI classification results were calculated with a combination of leave-one-out cross-validation and bootstrapping. A DSF visualization of a FTD patient is presented as an example. Results: The DSI distinguishes controls from FTD (area under the receiver-operator curve, AUC = 0.99) and AD (AUC = 1.00) very well and achieves a good differential diagnosis between AD and FTD (AUC = 0.89). In subsamples of autopsy-confirmed cases (AUC = 0.97) and clinically diagnosed cases (AUC = 0.94), differential diagnosis of AD and FTD performs very well. Conclusions: DSI is a promising computer-assisted biomarker approach for aiding in the diagnostic process of dementing diseases. Here, DSI separates controls from dementia and differentiates between AD and FTD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Alzheimer's disease
- Frontotemporal dementia
- Computer-assisted diagnosis
- Magnetic resonance imaging
- Neuropsychology
- Single-photon emission tomography
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Munoz-Ruiz, Migu ...
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Hall, Anette
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Mattila, Jussi
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Koikkalainen, Ju ...
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Herukka, Sanna-K ...
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Husso, Minna
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show more...
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Hanninen, Tuomo
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Vanninen, Ritva
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Liu, Yawu
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Hallikainen, Mer ...
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Lotjonen, Jyrki
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Remes, Anne M.
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Alafuzoff, Irina
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Soininen, Hilkka
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Hartikainen, Pai ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Dementia and Ger ...
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Uppsala University