Lithium hyaluronate hydrogels enhance osteogenesis in vitro and ex vivo

• Lithium is a clinical drug for bipolar disorders and can enhance bone mass, promote osteogenesis of MSCs through inhibiting the Wnt/β-catenin signalling inhibitor GSK 3β. However, the systemic administration of lithium can trigger severe side-effects. Local administration has been attempted in the treatment of bone defects in animal models with positive outcomes. In this study, we explored a pre-manufactured hydrogel system containing the Li ion (Li-gel) in bone applications. Human MSCs cultured in this Li-gel exhibited enhanced osteogenic differentiation. Furthermore, this Li-gel was used to treat chick embryo chorioallantoic membrane (CAM) femur defects and enhanced the bone healing process. 

Ämnesord

TEKNIK OCH TEKNOLOGIER  -- Medicinteknik -- Medicinsk material- och protesteknik (hsv//swe)

ENGINEERING AND TECHNOLOGY  -- Medical Engineering -- Medical Materials (hsv//eng)

Nyckelord

Lithium

mesenchymal stem cells

bone morphogenetic protein

CAM model.

Teknisk fysik med inriktning mot nanoteknologi och funktionella material

Engineering Science with specialization in Nanotechnology and Functional Materials

Publikations- och innehållstyp

pop (ämneskategori)

ovr (ämneskategori)