Search: L773:1095 9130 OR L773:1046 2023
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Direct imaging of e...
Direct imaging of elemental distributions in tissue sections by laser ablation mass spectrometry
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- Shariatgorji, Mohammadreza (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Nilsson, Anna (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Bonta, Maximilian (author)
- TU Wien, Inst Chem Technol & Analyt, Vienna, Austria.
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- Gan, Jinrui (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Fudan Univ, Dept Chem, Inst Biomed Sci, Shanghai, Peoples R China.;Fudan Univ, State Key Lab Mol Engn Polymers, Shanghai, Peoples R China.
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- Marklund, Niklas (author)
- Uppsala universitet,Neurokirurgi
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- Clausen, Fredrik (author)
- Uppsala universitet,Neurokirurgi
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- Kallback, Patrik (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Lodén, Henrik (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Limbeck, Andreas (author)
- TU Wien, Inst Chem Technol & Analyt, Vienna, Austria.
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Andrén, Per E. (author)
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
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In: Methods. - : Elsevier BV. - 1046-2023 .- 1095-9130. ; 104, s. 86-92
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- We present a strategy for imaging of elements in biological tissues using laser ablation (LA) mass spectrometry (MS), which was compared to laser ablation inductively coupled plasma (LA-ICP) MS. Both methods were adopted for quantitative imaging of elements in mouse kidney, as well as traumatic brain injury model tissue sections. MS imaging (MSI) employing LA provides quantitative data by comparing signal abundances of sodium from tissues to those obtained by imaging quantitation calibration standards of the target element applied to adjacent control tissue sections. LA-ICP MSI provided quantitative data for several essential elements in both brain and kidney tissue sections using a dried-droplet approach. Both methods were used to image a rat model of traumatic brain injury, revealing accumulations of sodium and calcium in the impact area and its peripheral regions. LA MSI is shown to be a viable option for quantitative imaging of specific elements in biological tissue sections.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Brain
- Kidney
- Elemental imaging
- Mass spectrometry
- Laser ablation
- Inductively coupled plasma
Publication and Content Type
- ref (subject category)
- art (subject category)
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Shariatgorji, Mo ...
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Nilsson, Anna
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Bonta, Maximilia ...
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Gan, Jinrui
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Marklund, Niklas
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Clausen, Fredrik
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show more...
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Kallback, Patrik
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Lodén, Henrik
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Limbeck, Andreas
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Andrén, Per E.
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show less...
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Uppsala University