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  • Ehnhage, AndersKarolinska Institute,Karolinska Institutet (author)

Treatment of idiopathic rhinitis with kinetic oscillations : a multi-centre randomized controlled study

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2016-04-07
  • Informa UK Limited,2016
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-308378
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-308378URI
  • https://doi.org/10.3109/00016489.2016.1155231DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:134006094URI
  • https://lup.lub.lu.se/record/930354e3-bb94-419e-8115-02b89eab1f82URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Conclusions: The potential effects of KOS are still uncertain regarding the most effective air pressure to be used as well as the physiological effects on the nasal mucosa. The results of the study do not support a convincing treatment effect by KOS on IR.Objectives: Idiopathic rhinitis (IR) is a common disorder, affecting ∼10-20% of the population. A new method for treating IR, Kinetic Oscillation Stimulation (KOS), has been reported to have beneficial effects on total vasomotor symptom scores (TVRSS). The primary objective with this study was to evaluate if a mean pressure of 65 mbar, pressure amplitude of 100 mbar, and 68Hz treatment with KOS had a positive effect on total vasomotor symptom scores (TVRSS), as compared with a mean pressure of 65 mbar, pressure amplitude of 4 mbar, and 68Hz treatment in patients with idiopathic rhinitis.Methods: Two hundred and seven patients were randomized (Full Analysis Set, FAS) in the study, including five visits and lasting for approximate to 25 weeks. All patients had two treatment episodes, and all patients had at least one treatment, meant as active, with high amplitude pressure for 10min in each nostril. Group 1 had two such treatments, and Group 2 had one treatment with low amplitude pressure, initially meant as placebo, on one occasion. Because of numerical improvements in these two groups, a new control group, Group 3, was introduced. They had one new control treatment where the balloon was inserted into the nose, without any air inflation and without oscillations.Results: KOS treatment with high amplitude pressure did not have significant beneficial effects as compared to low amplitude pressure on TVRSS. Numerical improvements in TVRSS and SNOT 22 were found when comparing high and low amplitude pressure treatments with uninflated balloon treatment. However, this part of the study was initially single-blinded, and these results were secondary objectives.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Sahlstrand Johnson, PernillaLund University,Lunds universitet,Öron-, näs- och halssjukdomar, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Otorhinolaryngology (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)oron-psa (author)
  • Ahlström-Emanuelsson, CeciliaLund University,Lunds universitet,Öron-, näs- och halssjukdomar, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Otorhinolaryngology (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)onh-cah (author)
  • Andersson, MorganLund University,Lunds universitet,Öron-, näs- och halssjukdomar, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Otorhinolaryngology (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)onh-man (author)
  • Knutsson, JohanUppsala universitet,Centrum för klinisk forskning, Västerås,Öron-, näs- och halssjukdomar,Västmanland Hospital(Swepub:uu)johkn731 (author)
  • Lien, JacobKarolinska Institute (author)
  • Norlander, TomasAleris Sabbatsbergs Hosp, Stockholm, Sweden,Sabbatsberg Hospital (author)
  • Olsson, PetterKarolinska Institute,Karolinska Institutet (author)
  • Friis-Liby, Jan-EricFriis Liby & Ronndahl ENT Practice, Gothenburg, Sweden (author)
  • Holmström, MatsKarolinska Institute,Karolinska Institutet (author)
  • Karolinska InstituteKarolinska Institutet (creator_code:org_t)

Related titles

  • In:Acta Oto-Laryngologica: Informa UK Limited136:8, s. 852-8590001-64891651-2251

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