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15-year follow-up o...
15-year follow-up of the Second Nordic Mantle Cell Lymphoma trial (MCL2) : prolonged remissions without survival plateau
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- Eskelund, Christian W. (author)
- Rigshosp, Dept Haematol, Copenhagen, Denmark.,Copenhagen University Hospital
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- Kolstad, Arne (author)
- Oslo Univ Hosp, Dept Oncol, Oslo, Norway.,Oslo university hospital
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- Jerkeman, Mats (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Raty, Riikka (author)
- Univ Helsinki, Dept Haematol, Cent Hosp, Helsinki, Finland.,Helsinki University Central Hospital
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- Laurell, Anna (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Uppsala University Hospital
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- Eloranta, Sandra (author)
- Karolinska Institutet,Karolinska Institute
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- Smedby, Karin E. (author)
- Karolinska Institutet,Karolinska Institute,Helsinki University Central Hospital
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- Husby, Simon (author)
- Rigshosp, Dept Haematol, Copenhagen, Denmark.,Copenhagen University Hospital
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- Pedersen, Lone B. (author)
- Rigshosp, Dept Haematol, Copenhagen, Denmark.,Copenhagen University Hospital
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- Andersen, Niels S. (author)
- Rigshosp, Dept Haematol, Copenhagen, Denmark.,Copenhagen University Hospital
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- Eriksson, Mikael (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Kimby, Eva (author)
- Karolinska Institutet,Karolinska Institute
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- Bentzen, Hans (author)
- Aarhus Univ Hosp, Dept Haematol, Aarhus, Denmark.,Aarhus University Hospital
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- Kuittinen, Outi (author)
- Oulu Univ Hosp, Dept Radiotherapy & Oncol, Oulu, Finland.,Oulu University Hospital
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- Lauritzsen, Grete F. (author)
- Oslo Univ Hosp, Dept Oncol, Oslo, Norway.,Oslo university hospital
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- Nilsson-Ehle, Herman (author)
- Sahlgrens Univ Hosp, Sect Haematol & Coagulat Med, Gothenburg, Sweden.,Sahlgrenska University Hospital
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- Ralfkiaer, Elisabeth (author)
- Rigshosp, Dept Haematol, Copenhagen, Denmark.,Copenhagen University Hospital
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- Ehinger, Mats (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Sundström, Christer (author)
- Uppsala universitet,Klinisk och experimentell patologi,Univ Uppsala Hosp, Dept Genet & Pathol, Uppsala, Sweden.,Rose-Marie Amini,Uppsala University Hospital
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- Delabie, Jan (author)
- Oslo Univ Hosp, Dept Pathol, Oslo, Norway.,Oslo university hospital
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- Karjalainen-Lindsberg, Marja-Liisa (author)
- Univ Helsinki, Dept Pathol, Cent Hosp, Helsinki, Finland.,Helsinki University Central Hospital
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- Workman, Christopher T. (author)
- Tech Univ Denmark, Dept Syst Biol, Lyngby, Denmark.;Univ Copenhagen, Dept Hlth Sci, Copenhagen, Denmark.,University of Copenhagen
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- Garde, Christian (author)
- Tech Univ Denmark, Dept Syst Biol, Lyngby, Denmark.;Univ Copenhagen, Dept Hlth Sci, Copenhagen, Denmark.,University of Copenhagen
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- Elonen, Erkki (author)
- Univ Helsinki, Dept Haematol, Cent Hosp, Helsinki, Finland.
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- Brown, Peter (author)
- Rigshosp, Dept Haematol, Copenhagen, Denmark.,Copenhagen University Hospital
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- Gronbaek, Kirsten (author)
- Rigshosp, Dept Haematol, Copenhagen, Denmark.
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- Geisler, Christian H. (author)
- Rigshosp, Dept Haematol, Copenhagen, Denmark.,Copenhagen University Hospital
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- Grønbæk, Kirsten (author)
- Copenhagen University Hospital
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Rigshosp, Dept Haematol, Copenhagen, Denmark Copenhagen University Hospital (creator_code:org_t)
- 2016-07-05
- 2016
- English.
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In: British Journal of Haematology. - : Wiley. - 0007-1048 .- 1365-2141. ; 175:3, s. 410-418
- Related links:
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http://dx.doi.org/10...
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Abstract
Subject headings
Close
- In recent decades, the prognosis of Mantle Cell Lymphoma (MCL) has been significantly improved by intensified first-line regimens containing cytarabine, rituximab and consolidation with high-dose-therapy and autologous stem cell transplantation. One such strategy is the Nordic MCL2 regimen, developed by the Nordic Lymphoma Group. We here present the 15-year updated results of the Nordic MCL2 study after a median follow-up of 114years: For all patients on an intent-to-treat basis, the median overall and progression-free survival was 127 and 85years, respectively. The MCL International Prognostic Index (MIPI), biological MIPI, including Ki67 expression (MIPI-B) and the MIPI-B including mIR-18b expression (MIPI-B-miR), in particular, significantly divided patients into distinct risk groups. Despite very long response durations of the low and intermediate risk groups, we observed a continuous pattern of relapse and the survival curves never reached a plateau. In conclusion, despite half of the patients being still alive and 40% in first remission after more than 12years, we still see an excess disease-related mortality, even among patients experiencing long remissions. Even though we consider the Nordic regimen as a very good choice of regimen, we recommend inclusion in prospective studies to explore the benefit of novel agents in the frontline treatment of MCL.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- Mantle Cell Lymphoma
- Non-Hodgkin Lymphoma
- clinical trials
- high dose therapy
- Patologi
- Pathology
- Clinical trials
- High dose therapy
- Mantle Cell Lymphoma
- Non-Hodgkin Lymphoma
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Eskelund, Christ ...
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Kolstad, Arne
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Jerkeman, Mats
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Raty, Riikka
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Laurell, Anna
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Eloranta, Sandra
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show more...
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Smedby, Karin E.
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Husby, Simon
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Pedersen, Lone B ...
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Andersen, Niels ...
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Eriksson, Mikael
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Kimby, Eva
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Bentzen, Hans
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Kuittinen, Outi
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Lauritzsen, Gret ...
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Nilsson-Ehle, He ...
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Ralfkiaer, Elisa ...
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Ehinger, Mats
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Sundström, Chris ...
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Delabie, Jan
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Karjalainen-Lind ...
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Workman, Christo ...
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Garde, Christian
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Elonen, Erkki
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Brown, Peter
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Gronbaek, Kirste ...
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Geisler, Christi ...
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Grønbæk, Kirsten
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Clinical Laborat ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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British Journal ...
- By the university
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Uppsala University
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Lund University
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Karolinska Institutet