The Effect of Thyroid Dysfunction on Plasma Creatinine Levels

Englund Flodström, IDepartment of Medical Biosciences, Umeå University, (författare)

Introduction: There are conflicting reports on how kidney function isaffected in patients with thyroid dysfunction. This study was designed toinvestigate how hypothyroidism and hyperthyroidism affect the concentration ofplasma creatinine in a large patient material.Methods: Patient results with simultaneous determinations of FT4, FT3,TSH and creatinine were extracted from the laboratory information system. Overan eight year period this yielded more than thousand cases with results fromthyroid function tests combined with plasma creatinine concentrations.Results: Median plasma levels of creatinine differed significantly inhypothyroid and hyperthyroid patients as compared to euthyroid controls.An approximate 20% increase and decrease in median plasma creatinineconcentration was found for hypothyroid and hyperthyroid patients, respectively.The differences were statistically significant (p<0.001) for both groups and stillso when divided according to gender. A correlation analysis showed a significantnegative correlation between the biologically active freeT3 and creatinine.Conclusion: Thyroid hormone correlates significantly to plasma creatinine.It is important to be aware of the relationship between thyroid function andkidney function when interpreting plasma creatinine results and to considerhypothyroidism or hyperthyroidism as a possible cause of an abnormal plasmacreatinine level.Further research is needed in order to uncover the mechanisms behi

Berggren, KarlDepartment of Laboratory Medicine, Unilabs, Sweden (författare)
Usener, BDepartment of Laboratory Medicine, Unilabs, Sweden (författare)
Broberg, HDepartment of Laboratory Medicine, Unilabs, Sweden (författare)
Larsson, AndersUppsala universitet,Biokemisk struktur och funktion(Swepub:uu)andlarss (författare)
Brattsand, GöranDepartment of Medical Biosciences, Umeå University, (författare)
Department of Medical Biosciences, Umeå University,Department of Laboratory Medicine, Unilabs, Sweden (creator_code:org_t)

Av författaren/redakt...: Englund Flodströ ...; Berggren, Karl; Usener, B; Broberg, H; Larsson, Anders; Brattsand, Göran

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Endokrinologi oc ...

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