Search: (WFRF:(Cahn Jean Yves)) pers:(Olsson Richard F) >
Does FLT3 Mutation ...
Does FLT3 Mutation Impact Survival After Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia? : A Center for International Blood and Marrow Transplant Research (CIBMTR) Analysis
-
- Deol, Abhinav (author)
- Wayne State Univ, Karmanos Canc Inst, Dept Oncol, 4100 John R,4 HWCRC, Detroit, MI 48201 USA.
-
- Sengsayadeth, Salyka (author)
- Vanderbilt Univ, Med Ctr, Nashville, TN USA.
-
- Ahn, Kwang Woo (author)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Soc, Div Biostat, Milwaukee, WI 53226 USA.
-
show more...
-
- Wang, Hai-Lin (author)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
-
- Aljurf, Mahmoud (author)
- King Faisal Specialist Hosp Ctr & Res, Dept Oncol, Riyadh, Saudi Arabia.
-
- Antin, Joseph Harry (author)
- Dana Farber Canc Inst, Dept Med Oncol, Ctr Hematol Oncol, Boston, MA 02115 USA.
-
- Battiwalla, Minoo (author)
- NHLBI, Hematol Branch, Bethesda, MD 20892 USA.
-
- Bornhauser, Martin (author)
- Carl Gustav Carus Univ Hosp, Dresden, Germany.
-
- Cahn, Jean-Yves (author)
- Univ Hosp, Dept Hematol, Grenoble, France.
-
- Camitta, Bruce (author)
- Med Coll Wisconsin, Midwest Ctr Canc & Blood Disorders, Milwaukee, WI 53226 USA.;Childrens Hosp Wisconsin, Milwaukee, WI 53201 USA.
-
- Chen, Yi-Bin (author)
- Massachusetts Gen Hosp, Div Hematol Oncol, Boston, MA 02114 USA.
-
- Cutler, Corey S. (author)
- Dana Farber Canc Inst, Dept Med Oncol, Ctr Hematol Oncol, Boston, MA 02115 USA.
-
- Gale, Robert Peter (author)
- Imperial Coll London, Dept Med, Div Expt Med, Hematol Res Ctr, London, England.
-
- Ganguly, Siddhartha (author)
- Univ Kansas, Med Ctr, Div Hematol & Oncol, Blood & Marrow Transplantat, Kansas City, KS 66103 USA.
-
- Hamadani, Mehdi (author)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
-
- Inamoto, Yoshihiro (author)
- Natl Canc Ctr, Div Hematopoiet Stem Cell Transplantat, Tokyo, Japan.
-
- Jagasia, Madan (author)
- Vanderbilt Univ, Med Ctr, Nashville, TN USA.
-
- Kamble, Rammurti (author)
- Baylor Coll Med, Ctr Cell & Gene Therapy, Div Hematol & Oncol, Houston, TX 77030 USA.
-
- Koreth, John (author)
- Dana Farber Canc Inst, Dept Med Oncol, Ctr Hematol Oncol, Boston, MA 02115 USA.
-
- Lazarus, Hillard M. (author)
- Univ Hosp Case Med Ctr, Seidman Canc Ctr, Cleveland, OH USA.
-
- Liesveld, Jane (author)
- Univ Rochester, Med Ctr, Dept Med, Rochester, NY 14642 USA.
-
- Litzow, Mark R. (author)
- Mayo Clin, Div Hematol, Rochester, NY USA.;Mayo Clin, Transplant Ctr, Rochester, NY USA.
-
- Marks, David I. (author)
- Univ Hosp Bristol Natl Hlth Serv Trust, Pediat Bone Marrow Transplant, Bristol, Avon, England.
-
- Nishihori, Taiga (author)
- H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplantat, Tampa, FL USA.
-
- Olsson, Richard F. (author)
- Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Div Therapeut Immunol, Dept Lab Med, Stockholm, Sweden.
-
- Reshef, Ran (author)
- Columbia Univ, Med Ctr, Blood & Marrow Transplantat Program, New York, NY USA.;Columbia Univ, Med Ctr, Columbia Ctr Translat Immunol, New York, NY USA.
-
- Rowe, Jacob M. (author)
- Shaare Zedek Med Ctr, Dept Hematol, Jerusalem, Israel.
-
- Saad, Ayman A. (author)
- Univ Alabama Birmingham, Dept Med, Div Hematol Oncol, Birmingham, AL 35294 USA.
-
- Sabloff, Mitchell (author)
- Univ Ottawa, Dept Med, Div Hematol, Ottawa, ON, Canada.;Ottawa Hosp, Res Inst, Ottawa, ON, Canada.
-
- Schouten, Harry C. (author)
- Acad Hosp Maastricht, Dept Hematol, Maastricht, Netherlands.
-
- Shea, Thomas C. (author)
- Univ North Carolina Hlth Care, Dept Med, Div Hematol & Oncol, Chapel Hill, NC USA.
-
- Soiffer, Robert J. (author)
- Dana Farber Canc Inst, Dept Med Oncol, Ctr Hematol Oncol, Boston, MA 02115 USA.
-
- Uy, Geoffrey L. (author)
- Washington Univ, Sch Med, Div Oncol, St Louis, MO USA.
-
- Waller, Edmond K. (author)
- Emory Univ, Winship Canc Inst, Dept Hematol & Med Oncol, Atlanta, GA 30322 USA.
-
- Wiernik, Peter H. (author)
- Our Lady Mercy Med Ctr, Bronx, NY USA.
-
- Wirk, Badeep (author)
- Seattle Canc Care Alliance, Div Bone Marrow Transplant, Seattle, WA USA.
-
- Woolfrey, Ann E. (author)
- Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA.
-
- Bunjes, Donald (author)
- Ulm Univ Hosp, Dept Internal Med 3, Ulm, Germany.
-
- Devine, Steven (author)
- Ohio State Univ, Dept Internal Med, Comprehens Canc Ctr James, Columbus, OH 43210 USA.
-
- de Lima, Marcos (author)
- Univ Hosp Case Med Ctr, Seidman Canc Ctr, Dept Med, Cleveland, OH USA.
-
- Sandmaier, Brenda M. (author)
- Univ Washington, Div Med Oncol, Seattle, WA 98195 USA.;Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA.
-
- Weisdorf, Dan (author)
- Natl Marrow Donor Program Be Match, Ctr Int Blood & Marrow Transplant Res, Minneapolis, MN USA.
-
- Khoury, Hanna Jean (author)
- Emory Univ, Winship Canc Inst, Dept Hematol & Med Oncol, Atlanta, GA 30322 USA.
-
- Saber, Wael (author)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
-
show less...
-
Wayne State Univ, Karmanos Canc Inst, Dept Oncol, 4100 John R,4 HWCRC, Detroit, MI 48201 USA Vanderbilt Univ, Med Ctr, Nashville, TN USA. (creator_code:org_t)
- 2016-06-17
- 2016
- English.
-
In: Cancer. - : Wiley. - 0008-543X .- 1097-0142. ; 122:19, s. 3005-3014
- Related links:
-
https://onlinelibrar...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- BACKGROUND: Patients with FMS like tyrosine kinase 3 (FLT3)-mutated acute myeloid leukemia (AML) have a poor prognosis and are referred for early allogeneic hematopoietic stem cell transplantation (HCT). METHODS: Data from the Center for International Blood and Marrow Transplant Research (CIBMTR) were used to evaluate 511 adult patients with de novo AML who underwent HCT during 2008 through 2011 to determine whether FLT3 mutations had an impact on HCT outcomes. RESULTS: In total, 158 patients (31%) had FLT3 mutations. Univariate and multivariate analyses revealed an increased risk of relapse at 3 years in the FLT3 mutated group compared with the wild-type (WT) group (38% [95% confidence interval (CI), 30%-45%] vs 28% [95% CI, 24%-33%]; P = .04; relative risk, 1.60 [95% CI, 1.15-2.22]; P = .0048). However, FLT3 mutation status was not significantly associated with nonrelapse mortality, leukemia-free survival, or overall survival. Although more patients in the FLT3 mutated group died from relapsed primary disease compared with those in the WT group (60% vs 46%), the 3-year overall survival rate was comparable for the 2 groups (mutated group: 49%; 95% CI, 40%-57%; WT group: 55%, 95% CI, 50%-60%; P = .20). CONCLUSIONS: The current data indicate that FLT3 mutation status did not adversely impact overall survival after HCT, and about 50% of patients with this mutation who underwent HCT were long-term survivors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- acute myeloid leukemia
- allogeneic stem cell transplantation
- FMS-like tyrosine kinase 3 (FLT3)
- 1 more
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Cancer
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Deol, Abhinav
-
Sengsayadeth, Sa ...
-
Ahn, Kwang Woo
-
Wang, Hai-Lin
-
Aljurf, Mahmoud
-
Antin, Joseph Ha ...
-
show more...
-
Battiwalla, Mino ...
-
Bornhauser, Mart ...
-
Cahn, Jean-Yves
-
Camitta, Bruce
-
Chen, Yi-Bin
-
Cutler, Corey S.
-
Gale, Robert Pet ...
-
Ganguly, Siddhar ...
-
Hamadani, Mehdi
-
Inamoto, Yoshihi ...
-
Jagasia, Madan
-
Kamble, Rammurti
-
Koreth, John
-
Lazarus, Hillard ...
-
Liesveld, Jane
-
Litzow, Mark R.
-
Marks, David I.
-
Nishihori, Taiga
-
Olsson, Richard ...
-
Reshef, Ran
-
Rowe, Jacob M.
-
Saad, Ayman A.
-
Sabloff, Mitchel ...
-
Schouten, Harry ...
-
Shea, Thomas C.
-
Soiffer, Robert ...
-
Uy, Geoffrey L.
-
Waller, Edmond K ...
-
Wiernik, Peter H ...
-
Wirk, Badeep
-
Woolfrey, Ann E.
-
Bunjes, Donald
-
Devine, Steven
-
de Lima, Marcos
-
Sandmaier, Brend ...
-
Weisdorf, Dan
-
Khoury, Hanna Je ...
-
Saber, Wael
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Hematology
- Articles in the publication
-
Cancer
- By the university
-
Uppsala University
-
Karolinska Institutet