Search: WFRF:(Mustjoki S)
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Increased proportio...
Increased proportion of mature NK cells is associated with successful imatinib discontinuation in chronic myeloid leukemia.
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- Ilander, M (author)
- University of Helsinki, Finland; Helsinki University Hospital, Finland
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- Olsson-Strömberg, Ulla (author)
- Uppsala University,Uppsala universitet,Hematologi,Uppsala University Hospital, Sweden; Uppsala University, Sweden
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- Schlums, H (author)
- Karolinska Institutet,Karolinska Institute, Sweden,Karolinska University Hospital
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- Guilhot, J (author)
- CHU Poitiers, France,Poitiers University Hospital
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- Brück, O (author)
- University of Helsinki, Finland; Helsinki University Hospital, Finland
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- Lähteenmäki, H (author)
- University of Helsinki, Finland; Helsinki University Hospital, Finland
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- Kasanen, T (author)
- University of Helsinki, Finland; Helsinki University Hospital, Finland
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- Koskenvesa, P (author)
- University of Helsinki, Finland; Helsinki University Hospital, Finland
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- Söderlund, Stina (author)
- Uppsala University,Karolinska Institutet,Uppsala universitet,Hematologi,Uppsala University Hospital, Sweden; Uppsala University, Sweden; Karolinska University Hospital, Sweden,Finnish Red Cross Blood Serv, Finland,Heidelberg University, Germany,University of Helsinki, Finland; Helsinki University Hospital, Finland; University of Helsinki, Finland,Finnish Red Cross Blood Transfusion Service
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- Höglund, Martin (author)
- Uppsala universitet,Hematologi,Uppsala University Hospital, Sweden
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- Markevärn, B (author)
- Umeå University Hospital, Sweden,Norrland University Hospital,Örebro University Hospital
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- Själander, Anders (author)
- Umeå universitet,Medicin,Sundsvall Research Unit, Umeå University,Umeå University, Sweden
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- Lotfi, Kourosh, 1966- (author)
- Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Region Östergötland, Hematologiska kliniken US,Linköping University Hospital
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- Dreimane, Arta (author)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Medicinska fakulteten,Region Östergötland, Hematologiska kliniken US,Linköping University Hospital
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- Lübking, A. (author)
- Skåne University Hospital, Sweden
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- Holm, E. (author)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital
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Björeman, M (author)
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- Lehmann, Sören (author)
- Uppsala universitet,Hematologi,Karolinska Univ Hosp, Div Hematol, Dept Med, Stockholm, Sweden
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- Stenke, L (author)
- Karolinska Institutet,Karolinska University Hospital, Sweden
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- Ohm, L (author)
- Karolinska University Hospital, Sweden
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- Gedde-Dahl, T (author)
- Oslo University Hospital, Norway,Norwegian Radium Hospital
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- Majeed, W (author)
- Stavanger University Hospital, Norway
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Ehrencrona, H (author)
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Koskela, S (author)
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Saussele, S (author)
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- Mahon, F-X (author)
- University of Bordeaux Segalen, France
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Porkka, K (author)
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- Hjorth-Hansen, H (author)
- St Olavs University Hospital, Norway
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- Bryceson, Y T (author)
- Karolinska Institutet,Karolinska Institute, Sweden,Karolinska University Hospital
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- Richter, J. (author)
- Lund University,Lunds universitet,Avdelningen för molekylärmedicin och genterapi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Molecular Medicine and Gene Therapy,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital
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Mustjoki, S (author)
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(creator_code:org_t)
- 2016-11-28
- 2017
- English.
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In: Leukemia. - : Springer Science and Business Media LLC. - 0887-6924 .- 1476-5551. ; 31:5, s. 1108-1116
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https://doi.org/10.1...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Recent studies suggest that a proportion of chronic myeloid leukemia (CML) patients in deep molecular remission can discontinue the tyrosine kinase inhibitor (TKI) treatment without disease relapse. In this multi-center, prospective clinical trial (EURO-SKI, NCT01596114) we analyzed the function and phenotype of T and NK cells and their relation to successful TKI cessation. Lymphocyte subclasses were measured from 100 imatinib-treated patients at baseline and 1 month after the discontinuation, and functional characterization of NK and T cells was done from 45 patients. The proportion of NK cells was associated with the molecular relapse-free survival as patients with higher than median NK-cell percentage at the time of drug discontinuation had better probability to stay in remission. Similar association was not found with T or B cells or their subsets. In non-relapsing patients the NK-cell phenotype was mature, whereas patients with more naïve CD56(bright) NK cells had decreased relapse-free survival. In addition, the TNF-α/IFN-γ cytokine secretion by NK cells correlated with the successful drug discontinuation. Our results highlight the role of NK cells in sustaining remission and strengthen the status of CML as an immunogenic tumor warranting novel clinical trials with immunomodulating agents.Leukemia advance online publication, 16 December 2016; doi:10.1038/leu.2016.360.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Leukemia
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To the university's database
- By the author/editor
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Ilander, M
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Olsson-Strömberg ...
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Schlums, H
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Guilhot, J
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Brück, O
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Lähteenmäki, H
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show more...
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Kasanen, T
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Koskenvesa, P
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Söderlund, Stina
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Höglund, Martin
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Markevärn, B
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Själander, Ander ...
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Lotfi, Kourosh, ...
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Dreimane, Arta
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Lübking, A.
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Holm, E.
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Björeman, M
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Lehmann, Sören
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Stenke, L
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Ohm, L
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Gedde-Dahl, T
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Majeed, W
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Ehrencrona, H
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Koskela, S
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Saussele, S
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Mahon, F-X
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Porkka, K
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Hjorth-Hansen, H
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Bryceson, Y T
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Richter, J.
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Mustjoki, S
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Leukemia
- By the university
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Uppsala University
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Umeå University
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Karolinska Institutet
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Linköping University
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Lund University