Search: WFRF:(Rinne Juha O) >
Increased striatal ...
Increased striatal VMAT2 binding in mice after chronic administration of methcathinone and manganese
-
- Asser, Andres (author)
- Univ Tartu, Dept Neurol & Neurosurg, Puusepa 8, EE-50409 Tartu, Estonia.
-
- Koks, Sulev (author)
- Univ Tartu, Dept Pathophysiol, Tartu, Estonia.
-
- Snellman, Anniina (author)
- Univ Turku, Turku PET Ctr, Turku, Finland.
-
show more...
-
- Haaparanta-Solin, Merja (author)
- Univ Turku, Turku PET Ctr, Turku, Finland.
-
- Arponen, Eveliina (author)
- Univ Turku, Turku PET Ctr, Turku, Finland.
-
- Gronroos, Tove (author)
- Univ Turku, Turku PET Ctr, Turku, Finland.
-
- Nairismagi, Jaak (author)
- Tallinn Univ Technol, Inst Gene Technol, Tallinn, Estonia.
-
- Bergquist, Jonas (author)
- Uppsala universitet,Analytisk kemi
-
- Soomets, Ursel (author)
- Univ Tartu, Dept Biochem, Tartu, Estonia.
-
- Piip, Piret (author)
- Univ Tartu, Dept Neurol & Neurosurg, Puusepa 8, EE-50409 Tartu, Estonia.
-
- Eltermaa, Mall (author)
- Univ Tartu, Dept Neurol & Neurosurg, Puusepa 8, EE-50409 Tartu, Estonia.
-
- Sauk, Martin (author)
- Univ Tartu, Dept Neurol & Neurosurg, Puusepa 8, EE-50409 Tartu, Estonia.
-
- Lindmae, Hanna (author)
- Univ Tartu, Dept Neurol & Neurosurg, Puusepa 8, EE-50409 Tartu, Estonia.
-
- Rinne, Juha O. (author)
- Univ Turku, Turku PET Ctr, Turku, Finland.;Turku Univ Hosp, Dept Neurol, Turku, Finland.
-
- Taba, Pille (author)
- Univ Tartu, Dept Neurol & Neurosurg, Puusepa 8, EE-50409 Tartu, Estonia.
-
show less...
-
Univ Tartu, Dept Neurol & Neurosurg, Puusepa 8, EE-50409 Tartu, Estonia Univ Tartu, Dept Pathophysiol, Tartu, Estonia. (creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
-
In: Brain Research. - : Elsevier BV. - 0006-8993 .- 1872-6240. ; 1652, s. 97-102
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Intravenous use of a psychostimulant drug containing methcathinone (ephedrone) and manganese causes an irreversible extrapyramidal syndrome in drug abusers. We aimed to reproduce the syndrome in mice to evaluate dopaminergic damage. C57/B6 mice were intraperitoneally injected once a day with the study drug or saline for a period of 27 weeks. Motor activity was recorded in an automated motility-box. After 13 and 27 weeks of treatment, ex vivo digital autoradiography was performed using [C-11]dihydrotetrabenazine ([C-11]DTBZ). After 27 weeks of treatment [C-11]DTBZ autoradiography demonstrated a significant increase in the striatum to -cerebellum binding ratio compared with saline treated controls. At the same time point, there was no evident change in motor activity. Increased [C-11]DTBZ binding may indicate vesicular monoamine transporter type 2 (VMAT2) function is altered. The lack of extrapyramidal symptoms in animals could be attributed to low dosing regimen or high metabolic rate.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Manganism
- Ephedrone
- Methcathinone
- VMAT2
- PET
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Asser, Andres
-
Koks, Sulev
-
Snellman, Anniin ...
-
Haaparanta-Solin ...
-
Arponen, Eveliin ...
-
Gronroos, Tove
-
show more...
-
Nairismagi, Jaak
-
Bergquist, Jonas
-
Soomets, Ursel
-
Piip, Piret
-
Eltermaa, Mall
-
Sauk, Martin
-
Lindmae, Hanna
-
Rinne, Juha O.
-
Taba, Pille
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Neurology
- Articles in the publication
-
Brain Research
- By the university
-
Uppsala University