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  • Campbell, B (author)

The effects of growing up on a farm on adult lung function and allergic phenotypes : an international population-based study

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2016-09-26
  • BMJ,2017
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-311302
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-311302URI
  • https://doi.org/10.1136/thoraxjnl-2015-208154DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • RATIONALE: Evidence has suggested that exposure to environmental or microbial biodiversity in early life may impact subsequent lung function and allergic disease risk.OBJECTIVES: To investigate the influence of childhood living environment and biodiversity indicators on atopy, asthma and lung function in adulthood.METHODS AND MEASUREMENTS: The European Community Respiratory Health Survey II investigated ∼10 201 participants aged 26-54 years from 14 countries, including participants' place of upbringing (farm, rural environment or inner city) before age 5 years. A 'biodiversity score' was created based on childhood exposure to cats, dogs, day care, bedroom sharing and older siblings. Associations with lung function, bronchial hyper-responsiveness (BHR), allergic sensitisation, asthma and rhinitis were analysed.MAIN RESULTS: As compared with a city upbringing, those with early-life farm exposure had less atopic sensitisation (adjusted OR 0.46, 95% CI 0.37 to 0.58), atopic BHR (0.54 (0.35 to 0.83)), atopic asthma (0.47 (0.28 to 0.81)) and atopic rhinitis (0.43 (0.32 to 0.57)), but not non-atopic outcomes. Less pronounced protective effects were observed for rural environment exposures. Women with a farm upbringing had higher FEV1 (adjusted difference 110 mL (64 to 157)), independent of sensitisation and asthma. In an inner city environment, a higher biodiversity score was related to less allergic sensitisation.CONCLUSIONS: This is the first study to report beneficial effects of growing up on a farm on adult FEV1. Our study confirmed the beneficial effects of early farm life on sensitisation, asthma and rhinitis, and found a similar association for BHR. In persons with an urban upbringing, a higher biodiversity score predicted less allergic sensitisation, but to a lesser magnitude than a childhood farm environment.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Raherison, C (author)
  • Lodge, C J (author)
  • Lowe, A J (author)
  • Gislason, T (author)
  • Heinrich, J (author)
  • Sunyer, J (author)
  • Gómez Real, F (author)
  • Norbäck, DanUppsala universitet,Arbets- och miljömedicin(Swepub:uu)dagnorba (author)
  • Matheson, M C (author)
  • Wjst, M (author)
  • Dratva, J (author)
  • de Marco, R (author)
  • Jarvis, D (author)
  • Schlünssen, V (author)
  • Janson, ChristerUppsala universitet,Lungmedicin och allergologi(Swepub:uu)chrisjn (author)
  • Leynaert, B (author)
  • Svanes, C (author)
  • Dharmage, S C (author)
  • Uppsala universitetArbets- och miljömedicin (creator_code:org_t)

Related titles

  • In:Thorax: BMJ72:3, s. 236-2440040-63761468-3296

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