Search: (WFRF:(Kassim Adetola A)) >
Maintenance versus ...
-
Cornell, Robert F
(author)
Maintenance versus Induction Therapy Choice on Outcomes after Autologous Transplantation for Multiple Myeloma
- Article/chapterEnglish2017
Publisher, publication year, extent ...
-
Elsevier BV,2017
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:uu-311936
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-311936URI
-
https://doi.org/10.1016/j.bbmt.2016.11.011DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:135082530URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Bortezomib (V), lenalidomide (R), cyclophosphamide (C), and dexamethasone (D) are components of the most commonly used modern doublet (RD, VD) or triplet (VRD, CVD) initial induction regimens before autologous hematopoietic cell transplantation (AHCT) for multiple myeloma (MM) in the United States. In this study we evaluated 693 patients receiving "upfront" AHCT after initial induction therapy with modern doublet or triplet regimens using data reported to the Center for International Blood and Marrow Transplant Research from 2008 to 2013. Analysis was limited to those receiving a single AHCT after 1 line of induction therapy within 12 months from treatment initiation for MM. In multivariate analysis, progression-free survival (PFS) and overall survival were similar irrespective of induction regimen. However, high-risk cytogenetics and nonreceipt of post-transplant maintenance/consolidation therapy were associated with higher risk of relapse. Patients receiving post-transplant therapy had significantly improved 3-year PFS versus no post-transplant therapy (55% versus 39%, P = .0001). This benefit was most evident in patients not achieving at least a complete response post-AHCT (P = .005). In patients receiving upfront AHCT, the choice of induction regimen (doublet or triplet therapies) appears to be of lower impact than use of post-transplant therapy.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
D'Souza, Anita
(author)
-
Kassim, Adetola A
(author)
-
Costa, Luciano J
(author)
-
Innis-Shelton, Racquel D
(author)
-
Zhang, Mei-Jie
(author)
-
Huang, Jiaxing
(author)
-
Abidi, Muneer
(author)
-
Aiello, Jack
(author)
-
Akpek, Gorgun
(author)
-
Bashey, Asad
(author)
-
Bashir, Qaiser
(author)
-
Cerny, Jan
(author)
-
Comenzo, Raymond
(author)
-
Diaz, Miguel Angel
(author)
-
Freytes, César
(author)
-
Gale, Robert Peter
(author)
-
Ganguly, Siddhartha
(author)
-
Hamadani, Mehdi
(author)
-
Hashmi, Shahrukh
(author)
-
Holmberg, Leona
(author)
-
Hossain, Nasheed
(author)
-
Kamble, Rammurti T
(author)
-
Kharfan-Dabaja, Mohamed
(author)
-
Kindwall-Keller, Tamila
(author)
-
Kyle, Robert
(author)
-
Kumar, Shaji
(author)
-
Lazarus, Hillard
(author)
-
Lee, Cindy
(author)
-
Maiolino, Angelo
(author)
-
Marks, David I
(author)
-
Meehan, Kenneth
(author)
-
Mikhael, Joe
(author)
-
Nath, Rajneesh
(author)
-
Nishihori, Taiga
(author)
-
Olsson, Richard F.Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD)(Swepub:uu)riols677
(author)
-
Ramanathan, Muthalagu
(author)
-
Saad, Ayman
(author)
-
Seo, Sachiko
(author)
-
Usmani, Saad
(author)
-
Vesole, David
(author)
-
Vij, Ravi
(author)
-
Vogl, Dan
(author)
-
Wirk, Baldeep M
(author)
-
Yared, Jean
(author)
-
Krishnan, Amrita
(author)
-
Mark, Tomer
(author)
-
Nieto, Yago
(author)
-
Hari, Parameswaran
(author)
-
Uppsala universitetCentrum för klinisk forskning i Sörmland (CKFD)
(creator_code:org_t)
Related titles
-
In:Biology of blood and marrow transplantation: Elsevier BV23:2, s. 269-2771083-87911523-6536
Internet link
Find in a library
To the university's database
- By the author/editor
-
Cornell, Robert ...
-
D'Souza, Anita
-
Kassim, Adetola ...
-
Costa, Luciano J
-
Innis-Shelton, R ...
-
Zhang, Mei-Jie
-
show more...
-
Huang, Jiaxing
-
Abidi, Muneer
-
Aiello, Jack
-
Akpek, Gorgun
-
Bashey, Asad
-
Bashir, Qaiser
-
Cerny, Jan
-
Comenzo, Raymond
-
Diaz, Miguel Ang ...
-
Freytes, César
-
Gale, Robert Pet ...
-
Ganguly, Siddhar ...
-
Hamadani, Mehdi
-
Hashmi, Shahrukh
-
Holmberg, Leona
-
Hossain, Nasheed
-
Kamble, Rammurti ...
-
Kharfan-Dabaja, ...
-
Kindwall-Keller, ...
-
Kyle, Robert
-
Kumar, Shaji
-
Lazarus, Hillard
-
Lee, Cindy
-
Maiolino, Angelo
-
Marks, David I
-
Meehan, Kenneth
-
Mikhael, Joe
-
Nath, Rajneesh
-
Nishihori, Taiga
-
Olsson, Richard ...
-
Ramanathan, Muth ...
-
Saad, Ayman
-
Seo, Sachiko
-
Usmani, Saad
-
Vesole, David
-
Vij, Ravi
-
Vogl, Dan
-
Wirk, Baldeep M
-
Yared, Jean
-
Krishnan, Amrita
-
Mark, Tomer
-
Nieto, Yago
-
Hari, Parameswar ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Hematology
- Articles in the publication
-
Biology of blood ...
- By the university
-
Uppsala University
-
Karolinska Institutet