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Anticollagen type I...
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Manivel, Vivek AnandUppsala universitet,Klinisk immunologi
(författare)
Anticollagen type II antibodies are associated with an acute onset rheumatoid arthritis phenotype and prognosticate lower degree of inflammation during 5 years follow-up
- Artikel/kapitelEngelska2017
Förlag, utgivningsår, omfång ...
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2017-03-23
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BMJ,2017
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-311956
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-311956URI
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https://doi.org/10.1136/annrheumdis-2016-210873DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:136405169URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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ObjectiveAntifibrillar collagen type II (anti-CII) antibody-positive patients with rheumatoid arthritis (RA) have early but not late signs of increased inflammation and joint erosions. We wanted to replicate this in a large RA cohort, and to relate to human leukocyte antigen (HLA)-DRB1* alleles.MethodsAnti-CII and anti-cyclic citrullinated peptide (CCP)2 were measured at baseline in 773 patients with RA from the Swedish Epidemiological Investigation in Rheumatoid Arthritis (EIRA) study with clinical follow-up data from the Swedish Rheumatology Quality Register (SRQ) registry, and 1476 with HLA-DRB1* information. Comparisons were done concerning C reactive protein (CRP), erythrocyte sedimentation rate (ESR), tender joint count (TJC), swollen joint count (SJC), Disease Activity Score encompassing 28 joints based on ESR (DAS28), DAS28CRP, pain-Visual Analogue Scale (VAS), global-VAS and Health Assessment Questionnaire Score (HAQ) at eight occasions during 5 years, and association with HLA-DRB1* alleles.ResultsAnti-CII associated with elevated CRP, ESR, SJC, DAS28 and DAS28CRP at diagnosis and up to 6 months, whereas anti-CCP2 associated with SJC and DAS28 from 6 months to 5 years, but not earlier. The anti-CII-associated phenotype was strong, and predominated in anti-CII/anti-CCP2 double-positive patients. Anti-CII was associated with improvements in CRP, ESR, SJC, TJC and DAS28, whereas anti-CCP2 was associated with deteriorations in SJC and DAS28 over time. Anti-CII-positive patients achieved European League Against Rheumatism good or moderate response more often than negative patients. Anti-CII was positively associated with HLA-DRB1*01 and HLA-DRB1*03, with significant interaction, and double-positive individuals had >14 times higher mean anti-CII levels than HLA double negatives. Whereas smoking was associated with elevated anti-CCP2 levels, smokers had lower anti-CII levels.ConclusionsAnti-CII seropositive RA represents a distinct phenotype, in many respects representing the converse to the clinical, genetic and smoking associations described for anticitrullinated protein peptide autoantibodies. Although not diagnostically useful, early anti-CII determinations predict favourable inflammatory outcome in RA.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Mullazehi, MohammedUppsala universitet,Klinisk immunologi(Swepub:uu)momul291
(författare)
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Padyukov, LeonidKarolinska Institutet
(författare)
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Westerlind, HelgaKarolinska Institutet
(författare)
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Klareskog, LarsKarolinska Institutet
(författare)
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Alfredson, LarsKarolinska Institutet
(författare)
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Saevarsdottir, SaedisKarolinska Institutet
(författare)
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Rönnelid, JohanUppsala universitet,Klinisk immunologi(Swepub:uu)joharonn
(författare)
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Uppsala universitetKlinisk immunologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Annals of the Rheumatic Diseases: BMJ76:9, s. 1529-15360003-49671468-2060
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