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KLB is associated w...
KLB is associated with alcohol drinking, and its gene product beta-Klotho is necessary for FGF21 regulation of alcohol preference
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- Schumann, Gunter (author)
- Kings Coll London, MRC, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England.
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- Liu, Chunyu (author)
- Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA.;NHLBI, Populat Sci Branch, Div Intramural Res, Bethesda, MD 20824 USA.;Boston Univ, Sch Publ, Dept Biostat, Boston, MA 02118 USA.
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- O'Reilly, Paul (author)
- Kings Coll London, MRC, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England.
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show more...
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- Gao, He (author)
- Imperial Coll London, Dept Epidemiol & Biostat, Sch Publ Hlth, London W2 1PG, England.;Imperial Coll London, MRC, Publ Hlth England Ctr Environm & Hlth, London W2 1PG, England.
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- Song, Parkyong (author)
- Univ Texas Southwestern Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA.;Univ Texas Southwestern Med Ctr Dallas, Howard Hughes Med Inst, Dallas, TX 75390 USA.
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- Xu, Bing (author)
- Kings Coll London, MRC, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England.
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- Ruggeri, Barbara (author)
- Kings Coll London, MRC, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England.
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- Amin, Najaf (author)
- Erasmus MC, Genet Epidemiol Unit, Dept Epidemiol, NL-3000 CA Rotterdam, Netherlands.
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- Jia, Tianye (author)
- Kings Coll London, MRC, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England.
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- Preis, Sarah (author)
- Boston Univ, Sch Publ, Dept Biostat, Boston, MA 02118 USA.
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- Lepe, Marcelo Segura (author)
- Imperial Coll London, Dept Epidemiol & Biostat, Sch Publ Hlth, London W2 1PG, England.;Bayer Pharma AG, Sect Bioinformat, D-13342 Berlin, Germany.
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- Akira, Shizuo (author)
- Osaka Univ, World Premier Int Immunol Frontier Res Ctr, Microbial Dis Res Inst, Lab Host Def, Osaka 5650871, Japan.
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- Barbieri, Caterina (author)
- San Raffaele Res Inst, Div Genet & Cell Biol, I-20132 Milan, Italy.
-
- Baumeister, Sebastian (author)
- Univ Med Greifswald, Inst Community Med, D-17475 Greifswald, Germany.;Univ Regensburg, Dept Epidemiol & Prevent Med, D-93053 Regensburg, Germany.
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- Cauchi, Stephane (author)
- Univ Lille 2, European Genom Inst Diabet, Lille Pasteur Inst, CNRS,UMR 8199, F-59000 Lille, France.
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- Clarke, Toni-Kim (author)
- Univ Edinburgh, Div Psychiat, Edinburgh EH10 5HF, Midlothian, Scotland.
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- Enroth, Stefan (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik
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- Fischer, Krista (author)
- Univ Tartu, Estonian Genome Ctr, EE-51010 Tartu, Estonia.
-
- Hallfors, Jenni (author)
- Univ Helsinki, Inst Mol Med, Helsinki 00290, Finland.
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- Harris, Sarah E. (author)
- Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH8 9JZ, Midlothian, Scotland.;Univ Edinburgh, Ctr Genom & Expt Med, Edinburgh EH4 2XU, Midlothian, Scotland.
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- Hieber, Saskia (author)
- Friedrich Alexander Univ Erlangen Nuremberg, Dept Psychiat & Psychotherapy, D-91054 Erlangen, Germany.
-
- Hofer, Edith (author)
- Med Univ Graz, Clin Div Neurogeriatr, Dept Neurol, A-8036 Graz, Austria.;Med Univ Graz, Inst Med Informat Stat & Documentat, A-8036 Graz, Austria.
-
- Hottenga, Jouke-Jan (author)
- Vrije Univ Amsterdam, Dept Biol Psychol, NL-1081 BT Amsterdam, Netherlands.;EMGO Inst Hlth & Care Res, NL-1081 BT Amsterdam, Netherlands.
-
- Johansson, Åsa (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik
-
- Joshi, PeterK. (author)
- Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh EH8 9AG, Midlothian, Scotland.
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- Kaartinen, Niina (author)
- Natl Inst Hlth & Welf, Helsinki 00271, Finland.
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- Laitinen, Jaana (author)
- Finnish Inst Occupat Hlth, Quantified Employee Unit, Helsinki 00250, Finland.
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- Lemaitre, Rozenn (author)
- Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98101 USA.
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- Loukola, Anu (author)
- Univ Helsinki, Inst Mol Med, Helsinki 00290, Finland.;Univ Helsinki, Dept Publ Hlth, FIN-00014 Helsinki, Finland.
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- Luan, Jian'an (author)
- Univ Cambridge, Sch Clin Med, MRC, Epidemiol Unit,Inst Metab Sci, Cambridge CB2 0QQ, England.
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- Lyytikainen, Leo-Pekka (author)
- Fimlab Labs, Dept Clin Chem, Tampere 33520, Finland.;Univ Tampere, Sch Med, Tampere 33520, Finland.
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- Mangino, Massimo (author)
- Kings Coll London, Dept Twin Res & Genet Epidemiol, London SE1 7EH, England.;Guys & St Thomas Fdn Trust, Natl Inst Hlth Res, Biomed Res Ctr, London SE1 9RT, England.
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- Manichaikul, Ani (author)
- Univ Virginia, Ctr Publ Hlth Genom, Dept Publ Hlth Sci, Charlottesville, VA 22903 USA.;Univ Virginia, Biostat Sect, Dept Publ Hlth Sci, Charlottesville, VA 22903 USA.
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- Mbarek, Hamdi (author)
- Vrije Univ Amsterdam, Dept Biol Psychol, NL-1081 BT Amsterdam, Netherlands.;EMGO Inst Hlth & Care Res, NL-1081 BT Amsterdam, Netherlands.
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- Milaneschi, Yuri (author)
- Vrije Univ Amsterdam, Inst Hlth & Care Res EMGO, Inst Hlth & Care Res, Dept Psychiat,Univ Med Ctr,Geestelijke Gezondheid, NL-1081 HL Amsterdam, Netherlands.;Vrije Univ Amsterdam, Neurosci Campus Amsterdam, Univ Med Ctr, Geestelijke Gezondheids Zorg GGZ InGeest, NL-1081 HL Amsterdam, Netherlands.
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- Moayyeri, Alireza (author)
- Imperial Coll London, Dept Epidemiol & Biostat, Sch Publ Hlth, London W2 1PG, England.;UCL, Inst Hlth Informat, London NW1 2DA, England.;UCL, Inst Hlth Informat, Farr Inst Hlth Informat Res, London NW1 2DA, England.
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- Mukamal, Kenneth (author)
- Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA.;Harvard Med Sch, Boston, MA 02215 USA.
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- Nelson, Christopher (author)
- Univ Leicester, Glenfield Hosp, Dept Cardiovasc Sci, Leicester LE3 9QP, Leics, England.;Glenfield Hosp, Natl Inst Hlth Res, Leicester Cardiovasc Biomed Res Unit, Leicester LE3 9QP, Leics, England.
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- Nettleton, Jennifer (author)
- Univ Texas Hlth Sci Ctr Houston, Div Epidemiol Human Genet & Environm Sci, Houston, TX 77225 USA.
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- Partinen, Eemil (author)
- Univ Tartu, Fac Med, EE-50411 Tartu, Estonia.
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- Rawal, Rajesh (author)
- Helmholtz Zentrum Munchen, Dept Mol Epidemiol, Inst Epidemiol 2, D-85764 Neuherberg, Germany.
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- Robino, Antonietta (author)
- Ist Ricovero & Cura Carattere Sci IRCCS Burlo Gar, Inst Maternal & Child Hlth, I-34137 Trieste, Italy.
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- Rose, Lynda (author)
- Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02215 USA.
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- Sala, Cinzia (author)
- San Raffaele Res Inst, Div Genet & Cell Biol, I-20132 Milan, Italy.
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- Satoh, Takashi (author)
- Osaka Univ, World Premier Int Immunol Frontier Res Ctr, Microbial Dis Res Inst, Lab Host Def, Osaka 5650871, Japan.
-
- Schmidt, Reinhold (author)
- Med Univ Graz, Clin Div Neurogeriatr, Dept Neurol, A-8036 Graz, Austria.
-
- Schrautz, Katharina (author)
- Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh EH8 9AG, Midlothian, Scotland.
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- Scott, Robert (author)
- Univ Cambridge, Sch Clin Med, MRC, Epidemiol Unit, Cambridge CB2 0QQ, England.
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- Smith, Albert Vernon (author)
- Iceland Heart Assoc, Res Inst, IS-201 Kopavogur, Iceland.
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- Starr, John M. (author)
- Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH8 9JZ, Midlothian, Scotland.;Univ Edinburgh, Alzheimer Scotland Res Ctr, Edinburgh EH8 9JZ, Midlothian, Scotland.
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- Teumer, Alexander (author)
- Univ Med Greifswald, Inst Community Med, D-17475 Greifswald, Germany.;Univ Med Greifswald, Interfac Inst Genet & Funct Genom, D-17475 Greifswald, Germany.
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- Trompet, Stella (author)
- Leiden Univ, Med Ctr, Dept Cardiol, NL-2300 RC Leiden, Netherlands.;Leiden Univ, Med Ctr, Dept Gerontol & Geriatr, NL-2300 RC Leiden, Netherlands.
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- Uitterlinden, Andre G. (author)
- Erasmus MC, Dept Internal Med, NL-3015 CN Rotterdam, Netherlands.;Erasmus MC, Dept Epidemiol, NL-3000 CA Rotterdam, Netherlands.
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- Venturini, Cristina (author)
- Kings Coll London, Dept Twin Res & Genet Epidemiol, London SE1 7EH, England.
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- Vergnaud, Anne-Claire (author)
- Imperial Coll London, Dept Epidemiol & Biostat, Sch Publ Hlth, London W2 1PG, England.
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- Verweij, Niek (author)
- Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, NL-9700 RB Groningen, Netherlands.
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- Vitart, Veronique (author)
- Univ Edinburgh, Western Gen Hosp, MRC, Human Genet Unit,Inst Genet & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland.
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- Vuckovic, Dragana (author)
- Univ Trieste, Dept Med Sci, I-34149 Trieste, Italy.
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- Wedenoja, Juho (author)
- Univ Helsinki, Dept Publ Hlth, FIN-00014 Helsinki, Finland.
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- Yengo, Loic (author)
- Univ Lille 2, European Genom Inst Diabet, Lille Pasteur Inst, CNRS,UMR 8199, F-59000 Lille, France.
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- Yu, Bing (author)
- Univ Texas Hlth Sci Ctr Houston, Human Genet Ctr, Houston, TX 77225 USA.;Univ Texas Hlth Sci Ctr Houston, Div Epidemiol, Houston, TX 77225 USA.
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- Zhang, Weihua (author)
- Imperial Coll London, Dept Epidemiol & Biostat, Sch Publ Hlth, London W2 1PG, England.;Ealing Gen Hosp, Dept Cardiol, Southall UB1 3HW, Middx, England.
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- Zhao, Jing Hua (author)
- Univ Cambridge, Sch Clin Med, MRC, Epidemiol Unit, Cambridge CB2 0QQ, England.
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- Boomsma, Dorret I. (author)
- Vrije Univ Amsterdam, Dept Biol Psychol, NL-1081 BT Amsterdam, Netherlands.;EMGO Inst Hlth & Care Res, NL-1081 BT Amsterdam, Netherlands.
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- Chambers, John (author)
- Imperial Coll London, Dept Epidemiol & Biostat, Sch Publ Hlth, London W2 1PG, England.;Ealing Gen Hosp, Dept Cardiol, Southall UB1 3HW, Middx, England.;Imperial Coll Healthcare Natl Hlth Serv Trust, London W12 0HS, England.
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- Chasman, Daniel I. (author)
- Harvard Med Sch, Boston, MA 02215 USA.;Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02215 USA.
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- Daniela, Toniolo (author)
- San Raffaele Res Inst, Div Genet & Cell Biol, I-20132 Milan, Italy.
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- de Geus, Eco (author)
- Vrije Univ Amsterdam, Dept Biol Psychol, NL-1081 BT Amsterdam, Netherlands.;EMGO Inst Hlth & Care Res, NL-1081 BT Amsterdam, Netherlands.
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- Deary, Ian (author)
- Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH8 9JZ, Midlothian, Scotland.;Univ Edinburgh, Psychol, Edinburgh EH8 9JZ, Midlothian, Scotland.
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- Eriksson, Johan G. (author)
- Natl Inst Hlth & Welf, Helsinki 00271, Finland.;Univ Helsinki, Dept Gen Practice & Primary Hlth Care, FIN-00014 Helsinki, Finland.;Univ Helsinki, Cent Hosp, Unit Gen Practice, FIN-00014 Helsinki, Finland.;Publ Hlth Res, Folkhalsan Res Ctr, Helsinki 00290, Finland.;Vasa Cent Hosp, Vaasa 65130, Finland.
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- Esko, Tonu (author)
- Univ Tartu, Estonian Genome Ctr, EE-51010 Tartu, Estonia.
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- Eulenburg, Volker (author)
- Friedrich Alexander Univ Erlangen Nuremberg, Inst Biochem & Mol Med, D-91054 Erlangen, Germany.
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- Franco, Oscar H. (author)
- Erasmus MC, Dept Epidemiol, NL-3000 CA Rotterdam, Netherlands.
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- Froguel, Philippe (author)
- Univ Lille 2, European Genom Inst Diabet, Lille Pasteur Inst, CNRS,UMR 8199, F-59000 Lille, France.;Imperial Coll London, Dept Genom Common Dis, Sch Publ Hlth, London W12 0HR, England.
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- Gieger, Christian (author)
- Helmholtz Zentrum Munchen, Dept Mol Epidemiol, Inst Epidemiol 2, D-85764 Neuherberg, Germany.
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- Grabe, Hans J. (author)
- Univ Med Greifswald, Dept Psychiat & Psychotherapy, D-17475 Greifswald, Germany.
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- Gudnason, Vilmundur (author)
- Iceland Heart Assoc, Res Inst, IS-201 Kopavogur, Iceland.;Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland.
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- Gyllensten, Ulf B. (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik
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- Harris, Tamara B. (author)
- NIA, NIH, Bethesda, MD 20892 USA.
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- Hartikainen, Anna-Liisa (author)
- Oulu Univ Hosp, Dept Obstet & Gynecol, Oulu 90029, Finland.;Univ Oulu, MRC, Oulu 90014, Finland.;Oulu Univ Hosp, Unit Primary Care, Oulu 90220, Finland.
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- Heath, Andrew C. (author)
- Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA.
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- Hocking, Lynne (author)
- Univ Aberdeen, Inst Med Sci, Aberdeen AB25 2ZD, Scotland.
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- Hofman, Albert (author)
- Erasmus MC, Dept Epidemiol, NL-3000 CA Rotterdam, Netherlands.
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- Huth, Cornelia (author)
- German Res Ctr Environm Hlth GmbH, Inst Epidemiol 2, Helmholtz Zentrum Munchen, D-85764 Neuherberg, Germany.
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- Jarvelin, Marjo-Riitta (author)
- Imperial Coll London, Dept Epidemiol & Biostat, Sch Publ Hlth, London W2 1PG, England.;Erasmus MC, Dept Internal Med, NL-3015 CN Rotterdam, Netherlands.;Oulu Univ Hosp, Unit Primary Care, Oulu 90220, Finland.;Univ Oulu, Fac Med, Ctr Life Course Epidemiol, FI-90014 Oulu, Finland.;Univ Oulu, Bioctr Oulu, FI-90014 Oulu, Finland.
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- Jukema, J. Wouter (author)
- Leiden Univ, Med Ctr, Dept Cardiol, NL-2300 RC Leiden, Netherlands.
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- Kaprio, Jaakko (author)
- Univ Helsinki, Inst Mol Med, Helsinki 00290, Finland.;Natl Inst Hlth & Welf, Helsinki 00271, Finland.;Univ Helsinki, Dept Publ Hlth, FIN-00014 Helsinki, Finland.
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- Kooner, Jaspal S. (author)
- Ealing Gen Hosp, Dept Cardiol, Southall UB1 3HW, Middx, England.;Imperial Coll Healthcare Natl Hlth Serv Trust, London W12 0HS, England.;Imperial Coll London, Hammersmith Hosp, Natl Heart & Lung Inst, Fac Med,Cardiovasc Sci, London W12 0NN, England.
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- Kutalik, Zoltan (author)
- Ctr Hosp Univ Vaudoise, Inst Social & Prevent Med, CH-1010 Lausanne, Switzerland.
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- Lahti, Jari (author)
- Publ Hlth Res, Folkhalsan Res Ctr, Helsinki 00290, Finland.;Univ Helsinki, Coll Adv Studies, FIN-00014 Helsinki, Finland.;Univ Helsinki, Inst Behav Sci, FIN-00014 Helsinki, Finland.
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- Langenberg, Claudia (author)
- Univ Cambridge, Sch Clin Med, MRC, Epidemiol Unit,Inst Metab Sci, Cambridge CB2 0QQ, England.
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- Lehtimaki, Terho (author)
- Fimlab Labs, Dept Clin Chem, Tampere 33520, Finland.;Univ Tampere, Sch Med, Tampere 33520, Finland.
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- Liu, Yongmei (author)
- Wake Forest Sch Med, Wake Forest Sch Med, Dept Epidemiol & Prevent, Publ Hlth Sci, Winston Salem, NC 27157 USA.
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- Madden, Pamela A. F. (author)
- Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA.
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- Martin, Nicholas (author)
- Queensland Inst Med Res, Berghofer Med Res Inst, Genet Epidemiol, Brisbane, Qld 4029, Australia.
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- Morrison, Alanna (author)
- Univ Texas Hlth Sci Ctr Houston, Human Genet Ctr, Houston, TX 77225 USA.
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- Penninx, Brenda (author)
- Vrije Univ Amsterdam, Inst Hlth & Care Res EMGO, Inst Hlth & Care Res, Dept Psychiat,Univ Med Ctr,Geestelijke Gezondheid, NL-1081 HL Amsterdam, Netherlands.;Vrije Univ Amsterdam, Neurosci Campus Amsterdam, Univ Med Ctr, Geestelijke Gezondheids Zorg GGZ InGeest, NL-1081 HL Amsterdam, Netherlands.
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- Pirastu, Nicola (author)
- Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh EH8 9AG, Midlothian, Scotland.;Univ Trieste, Dept Med Sci, I-34149 Trieste, Italy.
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- Psaty, Bruce (author)
- Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98101 USA.;Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.;Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA.;Grp Hlth Res Inst, Grp Hlth Cooperat, Seattle, WA 98101 USA.
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- Raitakari, Olli (author)
- Univ Turku, Dept Clin Physiol & Nucl Med, Turku Univ Hosp, FIN-20520 Turku, Finland.;Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, FIN-20520 Turku, Finland.
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- Ridker, Paul (author)
- Harvard Med Sch, Boston, MA 02215 USA.;Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02215 USA.
-
- Rose, Richard (author)
- Indiana Univ, Dept Psychol & Brain Sci, Bloomington, IN 47405 USA.
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- Rotter, Jerome I. (author)
- Univ Calif Los Angeles, Los Angeles Biomed Res Inst Harbor, Med Ctr, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA.
-
- Samani, Nilesh J. (author)
- Univ Leicester, Glenfield Hosp, Dept Cardiovasc Sci, Leicester LE3 9QP, Leics, England.;Glenfield Hosp, Natl Inst Hlth Res, Leicester Cardiovasc Biomed Res Unit, Leicester LE3 9QP, Leics, England.
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- Schmidt, Helena (author)
- Med Univ Graz, Inst Mol Biol & Biochem, Ctr Mol Med, A-8010 Graz, Austria.
-
- Spector, Tim D. (author)
- Kings Coll London, Dept Twin Res & Genet Epidemiol, London SE1 7EH, England.
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- Stott, David (author)
- Univ Glasgow, Inst Cardiovasc & Med Sci, Fac Med, Glasgow G31 2ER, Lanark, Scotland.
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- Strachan, David (author)
- St Georges Univ London, Populat Hlth Res Inst, London SW17 0RE, England.
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- Tzoulaki, Ioanna (author)
- Imperial Coll London, Dept Epidemiol & Biostat, Sch Publ Hlth, London W2 1PG, England.;Imperial Coll London, MRC, Publ Hlth England Ctr Environm & Hlth, London W2 1PG, England.;Univ Ioannina, Dept Hyg & Epidemiol, Med Sch, GR-45110 Ioannina, Greece.
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- van der Harst, Pim (author)
- Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, NL-9700 RB Groningen, Netherlands.;Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-9700 RB Groningen, Netherlands.;Netherlands Heart Inst, Durrer Ctr Cardiogenet Res, Interuniv Cardiol Inst Netherlands, NL-3511 GC Utrecht, Netherlands.
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- van Duijn, Cornelia M. (author)
- Erasmus MC, Genet Epidemiol Unit, Dept Epidemiol, NL-3000 CA Rotterdam, Netherlands.
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- Marques-Vidal, Pedro (author)
- Univ Lausanne Hosp, Dept Med, Internal Med, CH-1011 Lausanne, Switzerland.
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- Vollenweider, Peter (author)
- Univ Lausanne Hosp, Dept Med, Internal Med, CH-1011 Lausanne, Switzerland.
-
- Wareham, Nicholas J. (author)
- Univ Cambridge, Sch Clin Med, MRC, Epidemiol Unit, Cambridge CB2 0QQ, England.
-
- Whitfield, John B. (author)
- Queensland Inst Med Res, Berghofer Med Res Inst, Genet Epidemiol, Brisbane, Qld 4029, Australia.
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- Wilson, James (author)
- Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh EH8 9AG, Midlothian, Scotland.;Univ Edinburgh, Western Gen Hosp, MRC, Human Genet Unit,Inst Genet & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland.
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- Wolffenbuttel, Bruce (author)
- Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, NL-9700 RB Groningen, Netherlands.
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- Bakalkin, Georgy (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Evangelou, Evangelos (author)
- Imperial Coll London, Dept Epidemiol & Biostat, Sch Publ Hlth, London W2 1PG, England.;Univ Ioannina, Dept Hyg & Epidemiol, Med Sch, GR-45110 Ioannina, Greece.
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- Liu, Yun (author)
- Minist Educ, Key Lab Metab & Mol Med, Shanghai 200032, Peoples R China.;Fudan Univ, Shanghai Med Coll, Dept Biochem & Mol Biol, Shanghai 200032, Peoples R China.
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- Rice, Kenneth M. (author)
- Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
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- Desrivieres, Sylvane (author)
- Kings Coll London, MRC, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England.
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- Kliewer, Steven A. (author)
- Univ Texas Southwestern Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA.;Univ Texas Southwestern Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA.
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- Mangelsdorf, David J. (author)
- Univ Texas Southwestern Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA.;Univ Texas Southwestern Med Ctr Dallas, Howard Hughes Med Inst, Dallas, TX 75390 USA.
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- Muller, Christian P. (author)
- Friedrich Alexander Univ Erlangen Nuremberg, Dept Psychiat & Psychotherapy, D-91054 Erlangen, Germany.
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- Levy, Daniel (author)
- Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA.;NHLBI, Populat Sci Branch, Div Intramural Res, Bethesda, MD 20824 USA.
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- Elliott, Paul (author)
- Imperial Coll London, Dept Epidemiol & Biostat, Sch Publ Hlth, London W2 1PG, England.;Imperial Coll London, MRC, Publ Hlth England Ctr Environm & Hlth, London W2 1PG, England.
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Kings Coll London, MRC, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA.;NHLBI, Populat Sci Branch, Div Intramural Res, Bethesda, MD 20824 USA.;Boston Univ, Sch Publ, Dept Biostat, Boston, MA 02118 USA. (creator_code:org_t)
- 2016-11-28
- 2016
- English.
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 113:50, s. 14372-14377
- Related links:
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https://www.pnas.org...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Excessive alcohol consumption is a major public health problem worldwide. Although drinking habits are known to be inherited, few genes have been identified that are robustly linked to alcohol drinking. We conducted a genome-wide association metaanalysis and replication study among >105,000 individuals of European ancestry and identified beta-Klotho (KLB) as a locus associated with alcohol consumption (rs11940694; P = 9.2 x 10(-12)). beta-Klotho is an obligate coreceptor for the hormone FGF21, which is secreted from the liver and implicated in macronutrient preference in humans. We show that brain-specific beta-Klotho KO mice have an increased alcohol preference and that FGF21 inhibits alcohol drinking by acting on the brain. These data suggest that a liver-brain endocrine axis may play an important role in the regulation of alcohol drinking behavior and provide a unique pharmacologic target for reducing alcohol consumption.
Keyword
- alcohol consumption
- human
- beta-Klotho
- FGF21
- mouse model
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Schumann, Gunter
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Liu, Chunyu
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O'Reilly, Paul
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Gao, He
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Song, Parkyong
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Xu, Bing
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show more...
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Ruggeri, Barbara
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Amin, Najaf
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Jia, Tianye
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Preis, Sarah
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Lepe, Marcelo Se ...
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Akira, Shizuo
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Barbieri, Cateri ...
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Baumeister, Seba ...
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Cauchi, Stephane
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Clarke, Toni-Kim
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Enroth, Stefan
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Fischer, Krista
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Hallfors, Jenni
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Harris, Sarah E.
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Hieber, Saskia
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Hofer, Edith
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Hottenga, Jouke- ...
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Johansson, Åsa
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Joshi, PeterK.
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Kaartinen, Niina
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Laitinen, Jaana
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Lemaitre, Rozenn
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Loukola, Anu
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Luan, Jian'an
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Lyytikainen, Leo ...
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Mangino, Massimo
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Manichaikul, Ani
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Mbarek, Hamdi
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Milaneschi, Yuri
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Moayyeri, Alirez ...
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Mukamal, Kenneth
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Nelson, Christop ...
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Nettleton, Jenni ...
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Partinen, Eemil
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Rawal, Rajesh
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Robino, Antoniet ...
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Rose, Lynda
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Sala, Cinzia
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Satoh, Takashi
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Schmidt, Reinhol ...
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Schrautz, Kathar ...
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Scott, Robert
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Smith, Albert Ve ...
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Starr, John M.
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Teumer, Alexande ...
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Trompet, Stella
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Uitterlinden, An ...
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Lehtimaki, Terho
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