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Duplication of chic...
Duplication of chicken defensin7 gene generated by gene conversion and homologous recombination
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- Lee, Mi Ok (författare)
- Texas A&M Univ, Dept Vet Pathobiol, College Stn, TX 77843 USA.
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- Bornelöv, Susanne (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Univ Cambridge, Wellcome Trust Med Res Council Stem Cell Inst, Cambridge CB2 1QR, England.
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- Andersson, Leif (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi,Texas A&M Univ, Coll Vet Med, Dept Vet Integrat Biosci, College Stn, TX 77843 USA.
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- Lamont, Susan J. (författare)
- Iowa State Univ, Dept Anim Sci, Ames, IA 50011 USA.
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- Chen, Junfeng (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi,Texas A&M Univ, Dept Vet Pathobiol, College Stn, TX 77843 USA
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- Womack, James E. (författare)
- Texas A&M Univ, Dept Vet Pathobiol, College Stn, TX 77843 USA.
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Texas A&M Univ, Dept Vet Pathobiol, College Stn, TX 77843 USA Science for Life Laboratory, SciLifeLab (creator_code:org_t)
- 2016-11-14
- 2016
- Engelska.
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 113:48, s. 13815-13820
- Relaterad länk:
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https://www.pnas.org...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Defensins constitute an evolutionary conserved family of cationic antimicrobial peptides that play a key role in host innate immune responses to infection. Defensin genes generally reside in complex genomic regions that are prone to structural variation, and defensin genes exhibit extensive copy number variation in humans and in other species. Copy number variation of defensin genes was examined in inbred lines of Leghorn and Fayoumi chickens, and a duplication of defensin7 was discovered in the Fayoumi breed. Analysis of junction sequences confirmed the occurrence of a simple tandem duplication of defensin7 with sequence identity at the junction, suggesting nonallelic homologous recombination between defensin7 and defensin6. The duplication event generated two chimeric promoters that are best explained by gene conversion followed by homologous recombination. Expression of defensin7 was not elevated in animals with two genes despite both genes being transcribed in the tissues examined. Computational prediction of promoter regions revealed the presence of several putative transcription factor binding sites generated by the duplication event. These data provide insight into the evolution and possible function of large gene families and specifically, the defensins.
Ämnesord
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
Nyckelord
- antimicrobial peptides
- copy number variation
- defensin
- nonallelic homologous recombination
- chicken
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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