Sökning: id:"swepub:oai:DiVA.org:uu-313295" >
Psychological inter...
-
Brooks, S. J.Uppsala universitet,Funktionell farmakologi,Groote Schuur Hosp, Dept Psychiat & Mental Hlth, Cape Town, South Africa.;Univ Cape Town, MRC Unit Anxiety & Stress Disorders, ZA-7700 Rondebosch, South Africa.
(författare)
Psychological intervention with working memory training increases basal ganglia volume : A VBM study of inpatient treatment for methamphetamine use
- Artikel/kapitelEngelska2016
Förlag, utgivningsår, omfång ...
-
Elsevier BV,2016
-
electronicrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:uu-313295
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-313295URI
-
https://doi.org/10.1016/j.nicl.2016.08.019DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Background: Protracted methamphetamine (MA) use is associated with decreased control over drug craving and altered brain volume in the frontostriatal network. However, the nature of volumetric changes following a course of psychological intervention for MA use is not yet known. Methods: 66 males (41 MA patients, 25 healthy controls, HC) between the ages of 18-50 were recruited, the MA patients from new admissions to an in-patient drug rehabilitation centre and the HC via public advertisement, both in Cape Town, South Africa. 17 MA patients received 4 weeks of treatment as usual (TAU), and 24 MA patients completed TAU plus daily 30-minute cognitive training (CT) using an N-back working memory task. Magnetic resonance imaging (MRI) at baseline and 4-week follow-up was acquired and voxel-based morphometry (VBM) was used for analysis. Results: TAU was associated with larger bilateral striatum (caudate/putamen) volume, whereas CT was associated with more widespread increases of the bilateral basal ganglia (incorporating the amygdala and hippocampus) and reduced bilateral cerebellum volume coinciding with improvements in impulsivity scores. Conclusions: While psychological intervention is associated with larger volume in mesolimbic reward regions, the utilisation of additional working memory training as an adjunct to treatment may further normalize frontostriatal structure and function.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Burch, K. H.Groote Schuur Hosp, Dept Psychiat & Mental Hlth, Cape Town, South Africa.;Univ Cape Town, MRC Unit Anxiety & Stress Disorders, ZA-7700 Rondebosch, South Africa.;Univ Nottingham, Dept Neurosci, Nottingham NG7 2RD, England.
(författare)
-
Maiorana, S. A.Univ Cape Town, Dept Psychol, ZA-7700 Rondebosch, South Africa.
(författare)
-
Cocolas, E.Groote Schuur Hosp, Dept Psychiat & Mental Hlth, Cape Town, South Africa.;Univ Cape Town, MRC Unit Anxiety & Stress Disorders, ZA-7700 Rondebosch, South Africa.
(författare)
-
Schiöth, Helgi B.Uppsala universitet,Funktionell farmakologi(Swepub:uu)helgschi
(författare)
-
Nilsson, Emil K.Uppsala universitet,Funktionell farmakologi(Swepub:uu)emini542
(författare)
-
Kamaloodien, K.Univ Western Cape, Dept Psychol, Cape Town, South Africa.
(författare)
-
Stein, D. J.Groote Schuur Hosp, Dept Psychiat & Mental Hlth, Cape Town, South Africa.;Univ Cape Town, MRC Unit Anxiety & Stress Disorders, ZA-7700 Rondebosch, South Africa.
(författare)
-
Uppsala universitetFunktionell farmakologi
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:NeuroImage: Elsevier BV12, s. 478-4912213-1582
Internetlänk
Hitta via bibliotek
Till lärosätets databas