Interleukin-6 and C-reactive protein as prognostic biomarkers in metastatic colorectal cancer

Thomsen, MariaOslo Univ Hosp, Dept Oncol, Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway. (författare)

Objectives: The aim was to explore the prognostic significance of IL-6 and markers of systemic inflammatory response (SIR), in particular C-reactive protein (CRP), in metastatic colorectal cancer (mCRC) patients, in the total study population and according to RAS and BRAF mutation status. Results: High levels of pretreatment serum IL-6 or CRP were associated with impaired outcome, in terms of reduced PFS and OS. Patients with low versus high serum IL-6 levels had median OS of 26.0 versus 16.6 months, respectively (P < 0.001). Stratified according to increasing CRP levels, median OS varied from 24.3 months to 12.3 months, (P < 0.001). IL-6 and CRP levels affected overall prognosis also in adjusted analyses. The effect of IL-6 was particularly pronounced in patients with BRAF mutation (interaction P = 0.004). Materials and Methods: IL-6 and CRP were determined in pre-treatment serum samples from 393 patients included in the NORDIC-VII trial, in which patients with mCRC received first line treatment. The effect of serum IL-6 and CRP on progression-free survival (PFS) and overall survival (OS) was estimated. Conclusions: High baseline serum consentrations of IL-6 or CRP were associated with impaired prognosis in mCRC. IL-6 and CRP give independent prognostic information in addition to RAS and BRAF mutation status.

Kersten, ChristianSouthern Hosp Trust, Dept Oncol, Kristiansand, Norway. (författare)
Sorbye, HalfdanUniv Bergen, Haukeland Univ Hosp, Dept Oncol, Bergen, Norway. (författare)
Skovlund, EvaNorwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, Trondheim, Norway. (författare)
Glimelius, BengtUppsala universitet,Experimentell och klinisk onkologi(Swepub:uu)bengglim (författare)
Pfeiffer, PerUniv Southern Denmark, Odense Univ Hosp, Inst Clin Res, Dept Oncol, Odense, Denmark. (författare)
Johansen, Julia S.Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Oncol, Herlev, Denmark. (författare)
Kure, Elin H.Oslo Univ Hosp, Inst Canc Res, Dept Canc Genet, Oslo, Norway. (författare)
Ikdahl, ToneAkershus Univ Hosp, Nordbyhagen, Norway. (författare)
Tveit, Kjell MagneOslo Univ Hosp, Dept Oncol, Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway.;Oslo Univ Hosp, KG Jebsen Colorectal Canc Res Ctr, Oslo, Norway. (författare)
Christoffersen, ThoralfUniv Oslo, Fac Med, Inst Clin Med, Dept Pharmacol, Oslo, Norway. (författare)
Guren, Tormod KyrreOslo Univ Hosp, Dept Oncol, Oslo, Norway.;Oslo Univ Hosp, KG Jebsen Colorectal Canc Res Ctr, Oslo, Norway. (författare)
Oslo Univ Hosp, Dept Oncol, Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway.Southern Hosp Trust, Dept Oncol, Kristiansand, Norway. (creator_code:org_t)

Av författaren/redakt...: Thomsen, Maria; Kersten, Christi ...; Sorbye, Halfdan; Skovlund, Eva; Glimelius, Bengt; Pfeiffer, Per; visa fler...; Johansen, Julia ...; Kure, Elin H.; Ikdahl, Tone; Tveit, Kjell Mag ...; Christoffersen, ...; Guren, Tormod Ky ...; visa färre...

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