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Interleukin-6 and C...
Interleukin-6 and C-reactive protein as prognostic biomarkers in metastatic colorectal cancer
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- Thomsen, Maria (författare)
- Oslo Univ Hosp, Dept Oncol, Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway.
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- Kersten, Christian (författare)
- Southern Hosp Trust, Dept Oncol, Kristiansand, Norway.
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- Sorbye, Halfdan (författare)
- Univ Bergen, Haukeland Univ Hosp, Dept Oncol, Bergen, Norway.
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- Skovlund, Eva (författare)
- Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, Trondheim, Norway.
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- Glimelius, Bengt (författare)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Pfeiffer, Per (författare)
- Univ Southern Denmark, Odense Univ Hosp, Inst Clin Res, Dept Oncol, Odense, Denmark.
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- Johansen, Julia S. (författare)
- Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Oncol, Herlev, Denmark.
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- Kure, Elin H. (författare)
- Oslo Univ Hosp, Inst Canc Res, Dept Canc Genet, Oslo, Norway.
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- Ikdahl, Tone (författare)
- Akershus Univ Hosp, Nordbyhagen, Norway.
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- Tveit, Kjell Magne (författare)
- Oslo Univ Hosp, Dept Oncol, Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway.;Oslo Univ Hosp, KG Jebsen Colorectal Canc Res Ctr, Oslo, Norway.
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- Christoffersen, Thoralf (författare)
- Univ Oslo, Fac Med, Inst Clin Med, Dept Pharmacol, Oslo, Norway.
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- Guren, Tormod Kyrre (författare)
- Oslo Univ Hosp, Dept Oncol, Oslo, Norway.;Oslo Univ Hosp, KG Jebsen Colorectal Canc Res Ctr, Oslo, Norway.
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Oslo Univ Hosp, Dept Oncol, Oslo, Norway;Univ Oslo, Inst Clin Med, Oslo, Norway. Southern Hosp Trust, Dept Oncol, Kristiansand, Norway. (creator_code:org_t)
- 2016-10-12
- 2016
- Engelska.
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Ingår i: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 7:46, s. 75013-75022
- Relaterad länk:
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http://www.oncotarge...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objectives: The aim was to explore the prognostic significance of IL-6 and markers of systemic inflammatory response (SIR), in particular C-reactive protein (CRP), in metastatic colorectal cancer (mCRC) patients, in the total study population and according to RAS and BRAF mutation status. Results: High levels of pretreatment serum IL-6 or CRP were associated with impaired outcome, in terms of reduced PFS and OS. Patients with low versus high serum IL-6 levels had median OS of 26.0 versus 16.6 months, respectively (P < 0.001). Stratified according to increasing CRP levels, median OS varied from 24.3 months to 12.3 months, (P < 0.001). IL-6 and CRP levels affected overall prognosis also in adjusted analyses. The effect of IL-6 was particularly pronounced in patients with BRAF mutation (interaction P = 0.004). Materials and Methods: IL-6 and CRP were determined in pre-treatment serum samples from 393 patients included in the NORDIC-VII trial, in which patients with mCRC received first line treatment. The effect of serum IL-6 and CRP on progression-free survival (PFS) and overall survival (OS) was estimated. Conclusions: High baseline serum consentrations of IL-6 or CRP were associated with impaired prognosis in mCRC. IL-6 and CRP give independent prognostic information in addition to RAS and BRAF mutation status.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- mCRC
- IL-6
- CRP
- prognostic biomarker
- survival
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Thomsen, Maria
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Kersten, Christi ...
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Sorbye, Halfdan
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Skovlund, Eva
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Glimelius, Bengt
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Pfeiffer, Per
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visa fler...
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Johansen, Julia ...
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Kure, Elin H.
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Ikdahl, Tone
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Tveit, Kjell Mag ...
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Christoffersen, ...
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Guren, Tormod Ky ...
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