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Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with TP53 aberrations

Blanco, Gonzalo (author)
Hosp del Mar, Serv Patol, Lab Citol Hematol, Lab Citogenet Mol, Barcelona, Spain.;Hosp del Mar, IMIM, Canc Res Programme, Grp Recerca Translac Neoplasies Hematol, Barcelona, Spain.;Univ Pompeu Fabra, Dept Expt & Hlth Sci, Barcelona, Spain.
Puiggros, Anna (author)
Hosp del Mar, Serv Patol, Lab Citol Hematol, Lab Citogenet Mol, Barcelona, Spain.;Hosp del Mar, IMIM, Canc Res Programme, Grp Recerca Translac Neoplasies Hematol, Barcelona, Spain.
Baliakas, Panagiotis (author)
Uppsala universitet,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab
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Athanasiadou, Anastasia (author)
G Papanicolaou Hosp, Dept Hematol, Thessaloniki, Greece.;G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece.
Garcia-Malo, MaDolores (author)
Hosp Univ Morales Meseguer, Serv Hematol, Murcia, Spain.
Collado, Rosa (author)
Consorcio Hosp Gen Univ, Serv Hematol, Valencia, Spain.
Xochelli, Aliki (author)
Uppsala universitet,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab
Rodriguez-Rivera, Maria (author)
Hosp del Mar, Serv Patol, Lab Citol Hematol, Lab Citogenet Mol, Barcelona, Spain.;Hosp del Mar, IMIM, Canc Res Programme, Grp Recerca Translac Neoplasies Hematol, Barcelona, Spain.
Ortega, Margarita (author)
Hosp Valle De Hebron, Lab Citogenet, Barcelona, Spain.;Hosp Valle De Hebron, Serv Hematol, Barcelona, Spain.
Jose Calasanz, Ma (author)
Univ Navarra, Dept Genet, Serv Citogenet, Pamplona, Spain.
Luno, Elisa (author)
Hosp Univ Cent Asturias, Serv Hematol, Oviedo, Spain.
Vargas, MaTeresa (author)
Hosp Univ Virgen del Rocio, Inst Biomed Sevilla IBIS, UGC Hematol, Seville, Spain.
Grau, Javier (author)
Univ Autonoma Barcelona, Inst Recerca Leucemia Josep Carreras IJC, ICO Hosp Germans Trias & Pujol, Serv Hematol, Badalona, Spain.
Martinez-Laperche, Carolina (author)
Hosp GU Gregorio Maranon, Inst Invest Sanitaria Gregorio Maranon, Serv Hematol, Lab Genet Hematol, Madrid, Spain.
Valiente, Alberto (author)
Complejo Hospitalario Navarra, Serv Genet & Hematol, Pamplona, Spain.
Cervera, Jose (author)
Hosp Univ La Fe, Unidad Genet, Valencia, Spain.
Anagnostopoulos, Achilles (author)
G Papanicolaou Hosp, Dept Hematol, Thessaloniki, Greece.;G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece.
Gimeno, Eva (author)
Hosp del Mar, Serv Hematol, Barcelona, Spain.
Abella, Eugenia (author)
Hosp del Mar, Serv Hematol, Barcelona, Spain.
Stalika, Evangelia (author)
CERTH, Inst Appl Biosci, Thessaloniki, Greece.
Ma Hernandez-Rivas, Jesus (author)
Univ Salamanca, Hosp Univ Salamanca, Ctr Invest Canc, CSIC,Serv Hematol,IBSAL,IBMCC, Salamanca, Spain.
Jose Ortuno, Francisco (author)
Hosp Univ Morales Meseguer, Serv Hematol, Murcia, Spain.
Robles, Diego (author)
Hosp Txagorritxu, Serv Hematol, Vitoria, Spain.
Ferrer, Ana (author)
Hosp del Mar, Serv Patol, Lab Citol Hematol, Lab Citogenet Mol, Barcelona, Spain.;Hosp del Mar, IMIM, Canc Res Programme, Grp Recerca Translac Neoplasies Hematol, Barcelona, Spain.
Ivars, David (author)
Consorcio Hosp Gen Univ, Serv Hematol, Valencia, Spain.
Gonzalez, Marcos (author)
Univ Salamanca, Hosp Univ Salamanca, Ctr Invest Canc, CSIC,Serv Hematol,IBSAL,IBMCC, Salamanca, Spain.
Bosch, Francesc (author)
Hosp Valle De Hebron, Lab Citogenet, Barcelona, Spain.;Hosp Valle De Hebron, Serv Hematol, Barcelona, Spain.
Abrisqueta, Pau (author)
Hosp Valle De Hebron, Lab Citogenet, Barcelona, Spain.;Hosp Valle De Hebron, Serv Hematol, Barcelona, Spain.
Stamatopoulos, Kostas (author)
Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab,G Papanicolaou Hosp, Dept Hematol, Thessaloniki, Greece.;G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece.;CERTH, Inst Appl Biosci, Thessaloniki, Greece.
Espinet, Blanca (author)
Hosp del Mar, Serv Patol, Lab Citol Hematol, Lab Citogenet Mol, Barcelona, Spain.;Hosp del Mar, IMIM, Canc Res Programme, Grp Recerca Translac Neoplasies Hematol, Barcelona, Spain.
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Hosp del Mar, Serv Patol, Lab Citol Hematol, Lab Citogenet Mol, Barcelona, Spain;Hosp del Mar, IMIM, Canc Res Programme, Grp Recerca Translac Neoplasies Hematol, Barcelona, Spain.;Univ Pompeu Fabra, Dept Expt & Hlth Sci, Barcelona, Spain. Hosp del Mar, Serv Patol, Lab Citol Hematol, Lab Citogenet Mol, Barcelona, Spain.;Hosp del Mar, IMIM, Canc Res Programme, Grp Recerca Translac Neoplasies Hematol, Barcelona, Spain. (creator_code:org_t)
2016-11-04
2016
English.
In: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 7:49, s. 80916-80924
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https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Patients with chronic lymphocytic leukemia (CLL) harboring TP53 aberrations (TP53abs; chromosome 17p deletion and/or TP53 mutation) exhibit an unfavorable clinical outcome. Chromosome 8 abnormalities, namely losses of 8p (8p-) and gains of 8q (8q+) have been suggested to aggravate the outcome of patients with TP53abs. However, the reported series were small, thus hindering definitive conclusions. To gain insight into this issue, we assessed a series of 101 CLL patients harboring TP53 disruption. The frequency of 8p- and 8q+ was 14.7% and 17.8% respectively. Both were associated with a significantly (P < 0.05) higher incidence of a complex karyotype (CK, >= 3 abnormalities) detected by chromosome banding analysis (CBA) compared to cases with normal 8p (N-8p) and 8q (N-8q), respectively. In univariate analysis for 10- year overall survival (OS), 8p- (P = 0.002), 8q+ (P = 0.012) and CK (P = 0.009) were associated with shorter OS. However, in multivariate analysis only CK (HR = 2.47, P = 0.027) maintained independent significance, being associated with a dismal outcome regardless of chromosome 8 abnormalities. In conclusion, our results highlight the association of chromosome 8 abnormalities with CK amongst CLL patients with TP53abs, while also revealing that CK can further aggravate the prognosis of this aggressive subgroup.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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