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  • Blanco, GonzaloHosp del Mar, Serv Patol, Lab Citol Hematol, Lab Citogenet Mol, Barcelona, Spain.;Hosp del Mar, IMIM, Canc Res Programme, Grp Recerca Translac Neoplasies Hematol, Barcelona, Spain.;Univ Pompeu Fabra, Dept Expt & Hlth Sci, Barcelona, Spain. (author)

Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with TP53 aberrations

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2016-11-04
  • Impact Journals, LLC,2016
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-313534
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-313534URI
  • https://doi.org/10.18632/oncotarget.13106DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Patients with chronic lymphocytic leukemia (CLL) harboring TP53 aberrations (TP53abs; chromosome 17p deletion and/or TP53 mutation) exhibit an unfavorable clinical outcome. Chromosome 8 abnormalities, namely losses of 8p (8p-) and gains of 8q (8q+) have been suggested to aggravate the outcome of patients with TP53abs. However, the reported series were small, thus hindering definitive conclusions. To gain insight into this issue, we assessed a series of 101 CLL patients harboring TP53 disruption. The frequency of 8p- and 8q+ was 14.7% and 17.8% respectively. Both were associated with a significantly (P < 0.05) higher incidence of a complex karyotype (CK, >= 3 abnormalities) detected by chromosome banding analysis (CBA) compared to cases with normal 8p (N-8p) and 8q (N-8q), respectively. In univariate analysis for 10- year overall survival (OS), 8p- (P = 0.002), 8q+ (P = 0.012) and CK (P = 0.009) were associated with shorter OS. However, in multivariate analysis only CK (HR = 2.47, P = 0.027) maintained independent significance, being associated with a dismal outcome regardless of chromosome 8 abnormalities. In conclusion, our results highlight the association of chromosome 8 abnormalities with CK amongst CLL patients with TP53abs, while also revealing that CK can further aggravate the prognosis of this aggressive subgroup.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Puiggros, AnnaHosp del Mar, Serv Patol, Lab Citol Hematol, Lab Citogenet Mol, Barcelona, Spain.;Hosp del Mar, IMIM, Canc Res Programme, Grp Recerca Translac Neoplasies Hematol, Barcelona, Spain. (author)
  • Baliakas, PanagiotisUppsala universitet,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)panba345 (author)
  • Athanasiadou, AnastasiaG Papanicolaou Hosp, Dept Hematol, Thessaloniki, Greece.;G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece. (author)
  • Garcia-Malo, MaDoloresHosp Univ Morales Meseguer, Serv Hematol, Murcia, Spain. (author)
  • Collado, RosaConsorcio Hosp Gen Univ, Serv Hematol, Valencia, Spain. (author)
  • Xochelli, AlikiUppsala universitet,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)alixo978 (author)
  • Rodriguez-Rivera, MariaHosp del Mar, Serv Patol, Lab Citol Hematol, Lab Citogenet Mol, Barcelona, Spain.;Hosp del Mar, IMIM, Canc Res Programme, Grp Recerca Translac Neoplasies Hematol, Barcelona, Spain. (author)
  • Ortega, MargaritaHosp Valle De Hebron, Lab Citogenet, Barcelona, Spain.;Hosp Valle De Hebron, Serv Hematol, Barcelona, Spain. (author)
  • Jose Calasanz, MaUniv Navarra, Dept Genet, Serv Citogenet, Pamplona, Spain. (author)
  • Luno, ElisaHosp Univ Cent Asturias, Serv Hematol, Oviedo, Spain. (author)
  • Vargas, MaTeresaHosp Univ Virgen del Rocio, Inst Biomed Sevilla IBIS, UGC Hematol, Seville, Spain. (author)
  • Grau, JavierUniv Autonoma Barcelona, Inst Recerca Leucemia Josep Carreras IJC, ICO Hosp Germans Trias & Pujol, Serv Hematol, Badalona, Spain. (author)
  • Martinez-Laperche, CarolinaHosp GU Gregorio Maranon, Inst Invest Sanitaria Gregorio Maranon, Serv Hematol, Lab Genet Hematol, Madrid, Spain. (author)
  • Valiente, AlbertoComplejo Hospitalario Navarra, Serv Genet & Hematol, Pamplona, Spain. (author)
  • Cervera, JoseHosp Univ La Fe, Unidad Genet, Valencia, Spain. (author)
  • Anagnostopoulos, AchillesG Papanicolaou Hosp, Dept Hematol, Thessaloniki, Greece.;G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece. (author)
  • Gimeno, EvaHosp del Mar, Serv Hematol, Barcelona, Spain. (author)
  • Abella, EugeniaHosp del Mar, Serv Hematol, Barcelona, Spain. (author)
  • Stalika, EvangeliaCERTH, Inst Appl Biosci, Thessaloniki, Greece. (author)
  • Ma Hernandez-Rivas, JesusUniv Salamanca, Hosp Univ Salamanca, Ctr Invest Canc, CSIC,Serv Hematol,IBSAL,IBMCC, Salamanca, Spain. (author)
  • Jose Ortuno, FranciscoHosp Univ Morales Meseguer, Serv Hematol, Murcia, Spain. (author)
  • Robles, DiegoHosp Txagorritxu, Serv Hematol, Vitoria, Spain. (author)
  • Ferrer, AnaHosp del Mar, Serv Patol, Lab Citol Hematol, Lab Citogenet Mol, Barcelona, Spain.;Hosp del Mar, IMIM, Canc Res Programme, Grp Recerca Translac Neoplasies Hematol, Barcelona, Spain. (author)
  • Ivars, DavidConsorcio Hosp Gen Univ, Serv Hematol, Valencia, Spain. (author)
  • Gonzalez, MarcosUniv Salamanca, Hosp Univ Salamanca, Ctr Invest Canc, CSIC,Serv Hematol,IBSAL,IBMCC, Salamanca, Spain. (author)
  • Bosch, FrancescHosp Valle De Hebron, Lab Citogenet, Barcelona, Spain.;Hosp Valle De Hebron, Serv Hematol, Barcelona, Spain. (author)
  • Abrisqueta, PauHosp Valle De Hebron, Lab Citogenet, Barcelona, Spain.;Hosp Valle De Hebron, Serv Hematol, Barcelona, Spain. (author)
  • Stamatopoulos, KostasUppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab,G Papanicolaou Hosp, Dept Hematol, Thessaloniki, Greece.;G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece.;CERTH, Inst Appl Biosci, Thessaloniki, Greece.(Swepub:uu)kosst292 (author)
  • Espinet, BlancaHosp del Mar, Serv Patol, Lab Citol Hematol, Lab Citogenet Mol, Barcelona, Spain.;Hosp del Mar, IMIM, Canc Res Programme, Grp Recerca Translac Neoplasies Hematol, Barcelona, Spain. (author)
  • Hosp del Mar, Serv Patol, Lab Citol Hematol, Lab Citogenet Mol, Barcelona, Spain.;Hosp del Mar, IMIM, Canc Res Programme, Grp Recerca Translac Neoplasies Hematol, Barcelona, Spain.;Univ Pompeu Fabra, Dept Expt & Hlth Sci, Barcelona, Spain.Hosp del Mar, Serv Patol, Lab Citol Hematol, Lab Citogenet Mol, Barcelona, Spain.;Hosp del Mar, IMIM, Canc Res Programme, Grp Recerca Translac Neoplasies Hematol, Barcelona, Spain. (creator_code:org_t)

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  • In:Oncotarget: Impact Journals, LLC7:49, s. 80916-809241949-2553

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