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Karyotypic complexi...
Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with TP53 aberrations
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- Blanco, Gonzalo (author)
- Hosp del Mar, Serv Patol, Lab Citol Hematol, Lab Citogenet Mol, Barcelona, Spain.;Hosp del Mar, IMIM, Canc Res Programme, Grp Recerca Translac Neoplasies Hematol, Barcelona, Spain.;Univ Pompeu Fabra, Dept Expt & Hlth Sci, Barcelona, Spain.
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- Puiggros, Anna (author)
- Hosp del Mar, Serv Patol, Lab Citol Hematol, Lab Citogenet Mol, Barcelona, Spain.;Hosp del Mar, IMIM, Canc Res Programme, Grp Recerca Translac Neoplasies Hematol, Barcelona, Spain.
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- Baliakas, Panagiotis (author)
- Uppsala universitet,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab
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- Athanasiadou, Anastasia (author)
- G Papanicolaou Hosp, Dept Hematol, Thessaloniki, Greece.;G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece.
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- Garcia-Malo, MaDolores (author)
- Hosp Univ Morales Meseguer, Serv Hematol, Murcia, Spain.
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- Collado, Rosa (author)
- Consorcio Hosp Gen Univ, Serv Hematol, Valencia, Spain.
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- Xochelli, Aliki (author)
- Uppsala universitet,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab
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- Rodriguez-Rivera, Maria (author)
- Hosp del Mar, Serv Patol, Lab Citol Hematol, Lab Citogenet Mol, Barcelona, Spain.;Hosp del Mar, IMIM, Canc Res Programme, Grp Recerca Translac Neoplasies Hematol, Barcelona, Spain.
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- Ortega, Margarita (author)
- Hosp Valle De Hebron, Lab Citogenet, Barcelona, Spain.;Hosp Valle De Hebron, Serv Hematol, Barcelona, Spain.
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- Jose Calasanz, Ma (author)
- Univ Navarra, Dept Genet, Serv Citogenet, Pamplona, Spain.
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- Luno, Elisa (author)
- Hosp Univ Cent Asturias, Serv Hematol, Oviedo, Spain.
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- Vargas, MaTeresa (author)
- Hosp Univ Virgen del Rocio, Inst Biomed Sevilla IBIS, UGC Hematol, Seville, Spain.
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- Grau, Javier (author)
- Univ Autonoma Barcelona, Inst Recerca Leucemia Josep Carreras IJC, ICO Hosp Germans Trias & Pujol, Serv Hematol, Badalona, Spain.
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- Martinez-Laperche, Carolina (author)
- Hosp GU Gregorio Maranon, Inst Invest Sanitaria Gregorio Maranon, Serv Hematol, Lab Genet Hematol, Madrid, Spain.
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- Valiente, Alberto (author)
- Complejo Hospitalario Navarra, Serv Genet & Hematol, Pamplona, Spain.
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- Cervera, Jose (author)
- Hosp Univ La Fe, Unidad Genet, Valencia, Spain.
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- Anagnostopoulos, Achilles (author)
- G Papanicolaou Hosp, Dept Hematol, Thessaloniki, Greece.;G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece.
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- Gimeno, Eva (author)
- Hosp del Mar, Serv Hematol, Barcelona, Spain.
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- Abella, Eugenia (author)
- Hosp del Mar, Serv Hematol, Barcelona, Spain.
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- Stalika, Evangelia (author)
- CERTH, Inst Appl Biosci, Thessaloniki, Greece.
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- Ma Hernandez-Rivas, Jesus (author)
- Univ Salamanca, Hosp Univ Salamanca, Ctr Invest Canc, CSIC,Serv Hematol,IBSAL,IBMCC, Salamanca, Spain.
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- Jose Ortuno, Francisco (author)
- Hosp Univ Morales Meseguer, Serv Hematol, Murcia, Spain.
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- Robles, Diego (author)
- Hosp Txagorritxu, Serv Hematol, Vitoria, Spain.
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- Ferrer, Ana (author)
- Hosp del Mar, Serv Patol, Lab Citol Hematol, Lab Citogenet Mol, Barcelona, Spain.;Hosp del Mar, IMIM, Canc Res Programme, Grp Recerca Translac Neoplasies Hematol, Barcelona, Spain.
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- Ivars, David (author)
- Consorcio Hosp Gen Univ, Serv Hematol, Valencia, Spain.
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- Gonzalez, Marcos (author)
- Univ Salamanca, Hosp Univ Salamanca, Ctr Invest Canc, CSIC,Serv Hematol,IBSAL,IBMCC, Salamanca, Spain.
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- Bosch, Francesc (author)
- Hosp Valle De Hebron, Lab Citogenet, Barcelona, Spain.;Hosp Valle De Hebron, Serv Hematol, Barcelona, Spain.
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- Abrisqueta, Pau (author)
- Hosp Valle De Hebron, Lab Citogenet, Barcelona, Spain.;Hosp Valle De Hebron, Serv Hematol, Barcelona, Spain.
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- Stamatopoulos, Kostas (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab,G Papanicolaou Hosp, Dept Hematol, Thessaloniki, Greece.;G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece.;CERTH, Inst Appl Biosci, Thessaloniki, Greece.
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- Espinet, Blanca (author)
- Hosp del Mar, Serv Patol, Lab Citol Hematol, Lab Citogenet Mol, Barcelona, Spain.;Hosp del Mar, IMIM, Canc Res Programme, Grp Recerca Translac Neoplasies Hematol, Barcelona, Spain.
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Hosp del Mar, Serv Patol, Lab Citol Hematol, Lab Citogenet Mol, Barcelona, Spain;Hosp del Mar, IMIM, Canc Res Programme, Grp Recerca Translac Neoplasies Hematol, Barcelona, Spain.;Univ Pompeu Fabra, Dept Expt & Hlth Sci, Barcelona, Spain. Hosp del Mar, Serv Patol, Lab Citol Hematol, Lab Citogenet Mol, Barcelona, Spain.;Hosp del Mar, IMIM, Canc Res Programme, Grp Recerca Translac Neoplasies Hematol, Barcelona, Spain. (creator_code:org_t)
- 2016-11-04
- 2016
- English.
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In: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 7:49, s. 80916-80924
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http://www.oncotarge...
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https://doi.org/10.1...
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Abstract
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- Patients with chronic lymphocytic leukemia (CLL) harboring TP53 aberrations (TP53abs; chromosome 17p deletion and/or TP53 mutation) exhibit an unfavorable clinical outcome. Chromosome 8 abnormalities, namely losses of 8p (8p-) and gains of 8q (8q+) have been suggested to aggravate the outcome of patients with TP53abs. However, the reported series were small, thus hindering definitive conclusions. To gain insight into this issue, we assessed a series of 101 CLL patients harboring TP53 disruption. The frequency of 8p- and 8q+ was 14.7% and 17.8% respectively. Both were associated with a significantly (P < 0.05) higher incidence of a complex karyotype (CK, >= 3 abnormalities) detected by chromosome banding analysis (CBA) compared to cases with normal 8p (N-8p) and 8q (N-8q), respectively. In univariate analysis for 10- year overall survival (OS), 8p- (P = 0.002), 8q+ (P = 0.012) and CK (P = 0.009) were associated with shorter OS. However, in multivariate analysis only CK (HR = 2.47, P = 0.027) maintained independent significance, being associated with a dismal outcome regardless of chromosome 8 abnormalities. In conclusion, our results highlight the association of chromosome 8 abnormalities with CK amongst CLL patients with TP53abs, while also revealing that CK can further aggravate the prognosis of this aggressive subgroup.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- art (subject category)
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- By the author/editor
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Blanco, Gonzalo
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Puiggros, Anna
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Baliakas, Panagi ...
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Athanasiadou, An ...
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Garcia-Malo, MaD ...
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Collado, Rosa
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show more...
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Xochelli, Aliki
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Rodriguez-Rivera ...
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Ortega, Margarit ...
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Jose Calasanz, M ...
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Luno, Elisa
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Vargas, MaTeresa
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Grau, Javier
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Martinez-Laperch ...
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Valiente, Albert ...
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Cervera, Jose
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Anagnostopoulos, ...
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Gimeno, Eva
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Abella, Eugenia
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Stalika, Evangel ...
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Ma Hernandez-Riv ...
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Jose Ortuno, Fra ...
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Robles, Diego
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Ferrer, Ana
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Ivars, David
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Gonzalez, Marcos
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Bosch, Francesc
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Abrisqueta, Pau
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Stamatopoulos, K ...
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Espinet, Blanca
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Oncotarget
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Uppsala University