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Specific histone mo...
Specific histone modifications play critical roles in the control of encystation and antigenic variation in the early-branching eukaryote Giardia lamblia
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- Carranza, Pedro G. (författare)
- Univ Catolica Cordoba, Fac Med, Lab Bioquim & Biol Mol, Cordoba, Argentina.;CITSE, Santiago Del Estero, Argentina.
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- Gargantini, Pablo R. (författare)
- Univ Catolica Cordoba, Fac Med, Lab Bioquim & Biol Mol, Cordoba, Argentina.;Consejo Nacl Invest Cient & Tecn, Ctr Invest & Desarrollo Inmunol & Enfermedades In, Cordoba, Argentina.
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- Prucca, Cesar G. (författare)
- Univ Catolica Cordoba, Fac Med, Lab Bioquim & Biol Mol, Cordoba, Argentina.;Ctr Invest Quim Biol Cordoba CIQUIBIC, Cordoba, Argentina.
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- Torri, Alessandro (författare)
- Univ Catolica Cordoba, Fac Med, Lab Bioquim & Biol Mol, Cordoba, Argentina.
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- Saura, Alicia (författare)
- Univ Catolica Cordoba, Fac Med, Lab Bioquim & Biol Mol, Cordoba, Argentina.;Consejo Nacl Invest Cient & Tecn, Ctr Invest & Desarrollo Inmunol & Enfermedades In, Cordoba, Argentina.
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- Svärd, Staffan (författare)
- Uppsala universitet,Mikrobiologi
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- Lujan, Hugo D. (författare)
- Univ Catolica Cordoba, Fac Med, Lab Bioquim & Biol Mol, Cordoba, Argentina.;Consejo Nacl Invest Cient & Tecn, Ctr Invest & Desarrollo Inmunol & Enfermedades In, Cordoba, Argentina.
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Univ Catolica Cordoba, Fac Med, Lab Bioquim & Biol Mol, Cordoba, Argentina;CITSE, Santiago Del Estero, Argentina. Univ Catolica Cordoba, Fac Med, Lab Bioquim & Biol Mol, Cordoba, Argentina.;Consejo Nacl Invest Cient & Tecn, Ctr Invest & Desarrollo Inmunol & Enfermedades In, Cordoba, Argentina. (creator_code:org_t)
- Elsevier BV, 2016
- 2016
- Engelska.
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Ingår i: International Journal of Biochemistry and Cell Biology. - : Elsevier BV. - 1357-2725 .- 1878-5875. ; 81, s. 32-43
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- During evolution, parasitic microorganisms have faced the challenges of adapting to different environments to colonize a variety of hosts. Giardia lamblia, a common cause of intestinal disease, has developed fascinating strategies to adapt both outside and inside its host's intestine, such as trophozoite differentiation into cyst and the switching of its major surface antigens. How gene expression is regulated during these adaptive processes remains undefined. Giardia lacks some typical eukaryotic features, like canonical transcription factors, linker histone H1, and complex promoter regions; suggesting that post transcriptional and translational control of gene expression is essential for parasite survival. However, epigenetic factors may also play critical roles at the transcriptional level. Here, we describe the most common post -translational histone modifications; characterize enzymes involved in these reactions, and analyze their association with the Giardia's differentiation processes. We present evidence that NAD(+)-dependent and NAD(+)-independent histone deacetylases regulate encystation; however, a unique NAD(+)-independent histone deacetylase modulate antigenic switching. The rates of acetylation of H4K8 and H4K16 are critical for encystation, whereas a decrease in acetylation of H4K8 and methylation of H3K9 occur preferentially during antigenic variation. These results show the complexity of the mechanisms regulating gene expression in this minimalistic protozoan parasite.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Nyckelord
- Histone marks
- Cellular differentiation
- Gene regulation
- Histone methylases
- Histone deacetylases
- HDAC
- Sirtuin
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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