WFRF:(Ceda Gian Paolo)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03922naa a2200445 4500 | |
| 001 | oai:DiVA.org:uu-314144 | |
| 003 | SwePub | |
| 008 | 170128s2017 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:135406792 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3141442 URI |
| 024 | 7 | a https://doi.org/10.1016/j.exger.2016.12.0122 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1354067922 URI |
| 040 | a (SwePub)uud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Ticinesi, Andrea4 aut |
| 245 | 1 0 | a Uric acid and endothelial function in elderly community-dwelling subjects |
| 264 | 1 | b Elsevier BV,c 2017 |
| 338 | a print2 rdacarrier | |
| 520 | a The role of serum uric acid (SUA), an inflammatory agent and potential mediator of cardiovascular diseases, in endothelial function (EF) has been tested only in middle-aged subjects affected by specific diseases. Our aim was to assess the relationship between SUA and measures of EF in a cohort of elderly community-dwellers. This study involved 424 males and 426 females aged 70years from the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS), having complete data on SUA and EF assessed by flow-mediated vasodilation (FMD) and by intra-arterial infusion of acetylcholine (endothelium-dependent vasodilation, EDV) and sodium nitroprusside (endothelium-independent vasodilation, EIDV). Univariate and multivariate regression models obtained by backward selection from initial fully-adjusted models were built to assess the relationship between SUA and measures of EF in both genders. Cardiovascular risk factors, serum hormonal and metabolic mediators, and body composition were considered as potential confounders. In the univariate model, SUA was inversely associated in both genders with log(EDV) (β±SE males -0.39±0.17, p=0.03; females -0.57±0.19, p=0.003) and log(EIDV) (males -0.23±0.12, p=0.05; females -0.49±0.15, p=0.002), but not with log(FMD). After adjustment for BMI, only the association between SUA and log(EIDV) in females persisted, though attenuated (-0.32±0.16, p=0.049), and was no longer significant in the fully-adjusted multivariate model including waist/hip ratio. In conclusion, in older subjects, especially women, SUA is associated with EF not independently of a list of confounders including BMI and trunk fat mass, suggesting a role as surrogate metabolic marker rather than an active player in EF. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
| 700 | 1 | a Lauretani, Fulvio4 aut |
| 700 | 1 | a Ceda, Gian Paolo4 aut |
| 700 | 1 | a Ruggiero, Carmelinda4 aut |
| 700 | 1 | a Ferrucci, Luigi4 aut |
| 700 | 1 | a Aloe, Rosalia4 aut |
| 700 | 1 | a Larsson, Andersu Uppsala universitet,Biokemisk struktur och funktion4 aut0 (Swepub:uu)andlarss |
| 700 | 1 | a Cederholm, Tommyu Karolinska Institutet,Uppsala universitet,Klinisk nutrition och metabolism4 aut0 (Swepub:uu)tomce419 |
| 700 | 1 | a Lind, Larsu Uppsala universitet,Kardiovaskulär epidemiologi4 aut0 (Swepub:uu)larslind |
| 700 | 1 | a Meschi, Tiziana4 aut |
| 700 | 1 | a Maggio, Marcello4 aut |
| 710 | 2 | a Uppsala universitetb Biokemisk struktur och funktion4 org |
| 773 | 0 | t Experimental Gerontologyd : Elsevier BVg 89, s. 57-63q 89<57-63x 0531-5565x 1873-6815 |
| 856 | 4 | u https://europepmc.org/articles/pmc5672624?pdf=render |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-314144 |
| 856 | 4 8 | u https://doi.org/10.1016/j.exger.2016.12.012 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:135406792 |
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