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Dapagliflozin once-...
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Lundkvist, PerUppsala universitet,Klinisk diabetologi och metabolism
(författare)
Dapagliflozin once-daily and exenatide once-weekly dual therapy : A 24-week randomized, placebo-controlled, phase II study examining effects on body weight and prediabetes in obese adults without diabetes
- Artikel/kapitelEngelska2017
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2016-09-26
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Wiley,2017
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electronicrdacarrier
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LIBRIS-ID:oai:DiVA.org:uu-314407
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-314407URI
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https://doi.org/10.1111/dom.12779DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Aims: To explore the effects of dual therapy with dapagliflozin and exenatide on body weight, body composition, glycaemic variables and systolic blood pressure (SBP) in obese adults without diabetes.Materials and methods: In this single-centre, double-blind trial, we randomized 50 obese adults without diabetes (aged 18-70 years; body mass index 30-45 kg/m(2)) to oral dapagliflozin 10 mg once daily plus subcutaneous long-acting exenatide 2 mg once weekly or placebo. MRI was used to assess change in body composition. Participants were instructed to follow a balanced diet and exercise moderately.Results: Of 25 dapagliflozin/exenatide-and 25 placebo-treated participants, 23 (92.0%) and 20 (80.0%) completed 24 weeks of treatment, respectively. At baseline, the mean participant age was 52 years, 61% were female, the mean body weight was 104.6 kg, and 73.5% of participants had prediabetes (impaired fasting glucose or impaired glucose tolerance). After 24 weeks, for dapagliflozin/exenatide versus placebo: the difference in body weight change was -4.13 kg (95% confidence interval -6.44, -1.81; P <.001), which was mostly attributable to adipose tissue reduction without lean tissue change; 36.0% versus 4.2% of participants achieved >= 5% body weight loss, respectively; and prediabetes was less frequent with active treatment (34.8% vs 85.0%, respectively; P <.01). The difference in SBP change for dapagliflozin/ exenatide versus placebo was -6.7 mm Hg. As expected, nausea and injection-site reactions were more frequent with dapagliflozin/exenatide than with placebo. Only two and three participants, respectively, discontinued because of adverse events.Conclusions: Compared with placebo, dapagliflozin/exenatide dual therapy reduced body weight, frequency of prediabetes and SBP over 24 weeks and was well tolerated in obese adults without diabetes.
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Sjöström, C. DavidAstraZeneca, Gothenburg, Sweden.
(författare)
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Amini, SamUppsala universitet,Institutionen för medicinska vetenskaper
(författare)
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Pereira, Maria J.Uppsala universitet,Klinisk diabetologi och metabolism(Swepub:uu)marpe927
(författare)
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Johnsson, EvaAstraZeneca, Gothenburg, Sweden.
(författare)
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Eriksson, Jan W.Uppsala universitet,Klinisk diabetologi och metabolism(Swepub:uu)janer909
(författare)
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Uppsala universitetKlinisk diabetologi och metabolism
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Diabetes, obesity and metabolism: Wiley19:1, s. 49-601462-89021463-1326
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