Search: WFRF:(Helbling Leclerc A) >
The protein phospha...
The protein phosphatase 2A regulatory subunit PR70 is a gonosomal melanoma tumor suppressor gene
-
- van Kempen, Leon C. L. (author)
- McGill Univ, Dept Pathol, Montreal, PQ, Canada.;Lady Davis Inst Med Res, Montreal, PQ, Canada.
-
- Redpath, Margaret (author)
- McGill Univ, Dept Pathol, Montreal, PQ, Canada.;Lady Davis Inst Med Res, Montreal, PQ, Canada.
-
- Elchebly, Mounib (author)
- Lady Davis Inst Med Res, Montreal, PQ, Canada.
-
show more...
-
- Klein, Kathleen Oros (author)
- Lady Davis Inst Med Res, Montreal, PQ, Canada.
-
- Papadakis, Andreas I. (author)
- McGill Univ, Dept Pathol, Montreal, PQ, Canada.;Lady Davis Inst Med Res, Montreal, PQ, Canada.
-
- Wilmott, James S. (author)
- Royal Prince Alfred Hosp, Melanoma Inst Australia, Sydney, NSW, Australia.;Univ Sydney, Sydney, NSW, Australia.
-
- Scolyer, Richard A. (author)
- Royal Prince Alfred Hosp, Melanoma Inst Australia, Sydney, NSW, Australia.;Univ Sydney, Sydney, NSW, Australia.
-
- Edqvist, Per-Henrik (author)
- Uppsala universitet,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab
-
- Pontén, Fredrik (author)
- Uppsala universitet,Klinisk och experimentell patologi,Science for Life Laboratory, SciLifeLab
-
- Schadendorf, Dirk (author)
- Univ Hosp Essen, Dept Dermatol, Essen, Germany.;German Canc Consortium DKTK, Heidelberg, Germany.
-
- van Rijk, Anke F. (author)
- Lady Davis Inst Med Res, Montreal, PQ, Canada.
-
- Michiels, Stefan (author)
- Gustave Roussy, Serv Biostat & Epidemiol, Villejuif, France.;Univ Paris Sud, INSERM, UMR 1018, Ctr Res Epidemiol & Populat Hlth CESP, Le Kremlin Bicetre, France.
-
- Dumay, Anne (author)
- Univ Paris Diderot, Sorbonne Paris Cite, Labex Inflamex, INSERM,UMR S 1149,Ctr Rech Inflammat, Paris, France.
-
- Helbling-Leclerc, Anne (author)
- Univ Paris Sud, CNRS, UMR 8200, Villejuif, France.;Univ Paris Sud, Gustave Roussy, CNRS UMR 8200, Villejuif, France.
-
- Dessen, Philippe (author)
- Univ Paris Sud, Gustave Roussy, INSERM UMR 1170, Hematopoiese Normale & Pathol, Villejuif, France.
-
- Wouters, Jasper (author)
- Katholieke Univ Leuven, Lab Translat Cell & Tissue Res, Leuven, Belgium.;Katholieke Univ Leuven, VIB Ctr Biol Dis, Lab Computat Biol, Leuven, Belgium.;Katholieke Univ Leuven, Dept Human Genet, Leuven, Belgium.
-
- Stass, Marguerite (author)
- Katholieke Univ Leuven, Univ Hosp Leuven, Dept Surg Oncol, Leuven, Belgium.
-
- Greenwood, Celia M. T. (author)
- Lady Davis Inst Med Res, Montreal, PQ, Canada.;McGill Univ, Dept Oncol, Montreal, PQ, Canada.;McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.
-
- Ghanem, Ghanem E. (author)
- Univ Libre Bruxelles, Inst Jules Bordet, Lab Oncol & Expt Surg, Brussels, Belgium.
-
- van den Oord, Joost (author)
- Katholieke Univ Leuven, Lab Translat Cell & Tissue Res, Leuven, Belgium.
-
- Feunteun, Jean (author)
- Univ Paris Sud, Gustave Roussy, CNRS UMR 8200, Villejuif, France.
-
- Spatz, Alan (author)
- McGill Univ, Dept Pathol, Montreal, PQ, Canada.;Lady Davis Inst Med Res, Montreal, PQ, Canada.;McGill Univ, Dept Oncol, Montreal, PQ, Canada.
-
show less...
-
McGill Univ, Dept Pathol, Montreal, PQ, Canada;Lady Davis Inst Med Res, Montreal, PQ, Canada. Lady Davis Inst Med Res, Montreal, PQ, Canada. (creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2016
- 2016
- English.
-
In: Science Translational Medicine. - : American Association for the Advancement of Science (AAAS). - 1946-6234 .- 1946-6242. ; 8:369
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Male gender is independently and significantly associated with poor prognosis in melanoma of all clinical stages. The biological underpinnings of this sex difference remain largely unknown, but we hypothesized that gene expression from gonosomes (sex chromosomes) might play an important role. We demonstrate that loss of the inactivated X chromosome in melanomas arising in females is strongly associated with poor distant metastasis-free survival, suggesting a dosage benefit from two X chromosomes. The gonosomal protein phosphatase 2 regulatory subunit B, beta (PPP2R3B) gene is located on the pseudoautosomal region (PAR) of the X chromosome in females and the Y chromosome in males. We observed that, despite its location on the PAR that predicts equal dosage across genders, PPP2R3B expression was lower in males than in females and was independently correlated with poor clinical outcome. PPP2R3B codes for the PR70 protein, a regulatory substrate-recognizing subunit of protein phosphatase 2A. PR70 decreased melanoma growth by negatively interfering with DNA replication and cell cycle progression through its role in stabilizing the cell division cycle 6 (CDC6)-chromatin licensing and DNA replication factor 1 (CDT1) interaction, which delays the firing of origins of DNA replication. Hence, PR70 functionally behaves as an X-linked tumor suppressor gene.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
van Kempen, Leon ...
-
Redpath, Margare ...
-
Elchebly, Mounib
-
Klein, Kathleen ...
-
Papadakis, Andre ...
-
Wilmott, James S ...
-
show more...
-
Scolyer, Richard ...
-
Edqvist, Per-Hen ...
-
Pontén, Fredrik
-
Schadendorf, Dir ...
-
van Rijk, Anke F ...
-
Michiels, Stefan
-
Dumay, Anne
-
Helbling-Leclerc ...
-
Dessen, Philippe
-
Wouters, Jasper
-
Stass, Marguerit ...
-
Greenwood, Celia ...
-
Ghanem, Ghanem E ...
-
van den Oord, Jo ...
-
Feunteun, Jean
-
Spatz, Alan
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Cell and Molecul ...
- Articles in the publication
-
Science Translat ...
- By the university
-
Uppsala University