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Intra- and interreg...
Intra- and interregional coregulation of opioid genes : broken symmetry in spinal circuits
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- Kononenko, Olga (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Key State Laboratory, Bogomoletz Institute of Physiology, Kiev, Ukraine,Uppsala University, Uppsala, Sweden; Bogomoletz Institute of Physiology, Kiev, Ukraine
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- Galatenko, Vladimir (author)
- Moscow State University, Moscow, Russia
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- Andersson, Malin (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Uppsala University, Uppsala, Sweden
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- Bazov, Igor (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Uppsala University, Uppsala, Sweden
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- Watanabe, Hiroyuki (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Uppsala University, Uppsala, Sweden
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- Zhou, Xingwu (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Iatsyshyna, Anna (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Department of Human Genetics, Institute of Molecular Biology and Genetics, Kiev, Ukraine,Uppsala University, Uppsala, Sweden; Institute of Molecular Biology and Genetics, Kiev, Ukraine
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- Mityakina, Irina (author)
- Moscow State University, Moscow, Russia
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- Yakovleva, Tatiana (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Uppsala University, Uppsala, Sweden
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- Sarkisyan, Daniil (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Uppsala University, Uppsala, Sweden
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- Ponomarev, Igor (author)
- The University of Texas, Austin, Texas, USA
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- Krishtal, Oleg (author)
- Bogomoletz Institute of Physiology, Kiev, Ukraine
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- Marklund, Niklas (author)
- Uppsala universitet,Institutionen för neurovetenskap,Uppsala University Hospital, Uppsala, Sweden
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- Tonevitsky, Alex (author)
- Moscow State University, Moscow, Russia
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- Adkins, DeAnna L. (author)
- Medical University of South Carolina, Charleston, USA
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- Bakalkin, Georgy (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Uppsala University, Uppsala, Sweden
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- Zhou, Xing Wu (author)
- Uppsala University, Uppsala, Sweden
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(creator_code:org_t)
- John Wiley & Sons, 2017
- 2017
- English.
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In: The FASEB Journal. - : John Wiley & Sons. - 0892-6638 .- 1530-6860. ; 31:5, s. 1953-1963
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Regulation of the formation and rewiring of neural circuits by neuropeptides may require coordinated production of these signaling molecules and their receptors that may be established at the transcriptional level. Here, we address this hypothesis by comparing absolute expression levels of opioid peptides with their receptors, the largest neuropeptide family, and by characterizing coexpression (transcriptionally coordinated) patterns of these genes. We demonstrated that expression patterns of opioid genes highly correlate within and across functionally and anatomically different areas. Opioid peptide genes, compared with their receptor genes, are transcribed at much greater absolute levels, which suggests formation of a neuropeptide cloud that covers the receptor-expressed circuits. Surprisingly, we found that both expression levels and the proportion of opioid receptors are strongly lateralized in the spinal cord, interregional coexpression patterns are side specific, and intraregional coexpression profiles are affected differently by left-and right-side unilateral body injury. We propose that opioid genes are regulated as interconnected components of the same molecular system distributed between distinct anatomic regions. The striking feature of this system is its asymmetric coexpression patterns, which suggest side-specific regulation of selective neural circuits by opioid neurohormones.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Keyword
- neuropeptides
- spinal cord
- lateralization
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kononenko, Olga
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Galatenko, Vladi ...
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Andersson, Malin
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Bazov, Igor
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Watanabe, Hiroyu ...
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Zhou, Xingwu
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show more...
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Iatsyshyna, Anna
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Mityakina, Irina
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Yakovleva, Tatia ...
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Sarkisyan, Danii ...
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Ponomarev, Igor
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Krishtal, Oleg
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Marklund, Niklas
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Tonevitsky, Alex
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Adkins, DeAnna L ...
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Bakalkin, Georgy
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Zhou, Xing Wu
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Medical Biotechn ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Cell Biology
- Articles in the publication
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The FASEB Journa ...
- By the university
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Uppsala University
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Örebro University