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  • Gremel, GabrielaUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi (author)

A systematic search strategy identifies cubilin as independent prognostic marker for renal cell carcinoma

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017-01-04
  • Springer Science and Business Media LLC,2017
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-315058
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-315058URI
  • https://doi.org/10.1186/s12885-016-3030-6DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-200752URI

Supplementary language notes

  • Language:English
  • Summary in:English

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Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20170210
  • Background: There is an unmet clinical need for better prognostic and diagnostic tools for renal cell carcinoma (RCC). Methods: Human Protein Atlas data resources, including the transcriptomes and proteomes of normal and malignant human tissues, were searched for RCC-specific proteins and cubilin (CUBN) identified as a candidate. Patient tissue representing various cancer types was constructed into a tissue microarray (n = 940) and immunohistochemistry used to investigate the specificity of CUBN expression in RCC as compared to other cancers. Two independent RCC cohorts (n = 181; n = 114) were analyzed to further establish the sensitivity of CUBN as RCC-specific marker and to explore if the fraction of RCCs lacking CUBN expression could predict differences in patient survival. Results: CUBN was identified as highly RCC-specific protein with 58% of all primary RCCs staining positive for CUBN using immunohistochemistry. In venous tumor thrombi and metastatic lesions, the frequency of CUBN expression was increasingly lost. Clear cell RCC (ccRCC) patients with CUBN positive tumors had a significantly better prognosis compared to patients with CUBN negative tumors, independent of T-stage, Fuhrman grade and nodal status (HR 0.382, CI 0.203-0.719, P = 0.003). Conclusions: CUBN expression is highly specific to RCC and loss of the protein is significantly and independently associated with poor prognosis. CUBN expression in ccRCC provides a promising positive prognostic indicator for patients with ccRCC. The high specificity of CUBN expression in RCC also suggests a role as a new diagnostic marker in clinical cancer differential diagnostics to confirm or rule out RCC.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Djureinovic, DijanaUppsala universitet,Science for Life Laboratory, SciLifeLab,Klinisk och experimentell patologi(Swepub:uu)dijdj435 (author)
  • Niinivirta, MarjutUppsala universitet,Experimentell och klinisk onkologi(Swepub:uu)marni233 (author)
  • Laird, AlexanderUniv Edinburgh, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Inst Genet & Mol Med, Edinburgh Urol Canc Grp, Edinburgh, Midlothian, Scotland. (author)
  • Ljungqvist, OscarAtlas Antibodies AB, Stockholm, Sweden. (author)
  • Johannesson, HenrikAtlas Antibodies AB, Stockholm, Sweden. (author)
  • Bergman, JuliaUppsala universitet,Science for Life Laboratory, SciLifeLab,Klinisk och experimentell patologi(Swepub:uu)julbe256 (author)
  • Edqvist, Per-Henrik DUppsala universitet,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)peedq227 (author)
  • Navani, SanjayLab Surgpath, Bombay, Maharashtra, India. (author)
  • Khan, NailaLab Surgpath, Bombay, Maharashtra, India. (author)
  • Patil, TusharLab Surgpath, Bombay, Maharashtra, India. (author)
  • Sivertsson, ÅsaKTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u195d5b0 (author)
  • Uhlén, MathiasKTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1dulvmw (author)
  • Harrison, David J.Univ St Andrews, Sch Med, St Andrews, Fife, Scotland. (author)
  • Ullenhag, GustavUppsala universitet,Experimentell och klinisk onkologi(Swepub:uu)gustulle (author)
  • Stewart, Grant D.Univ Edinburgh, Inst Genet & Mol Med, Edinburgh Urol Canc Grp, Edinburgh, Midlothian, Scotland.;Univ Cambridge, Addenbrookes Hosp, Acad Urol Grp, Box 43,Cambridge Biomed Campus,Hills Rd, Cambridge CB2 0QQ, England. (author)
  • Pontén, FredrikUppsala universitet,Science for Life Laboratory, SciLifeLab,Klinisk och experimentell patologi(Swepub:uu)fredpont (author)
  • Uppsala universitetScience for Life Laboratory, SciLifeLab (creator_code:org_t)

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