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Maternal Smoking in...
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Neuman, ÅsaKarolinska Institutet,Uppsala universitet,Pediatrik,Karolinska Inst, Inst Environm Med, SE-17177 Stockholm, Sweden.
(author)
Maternal Smoking in Pregnancy and Asthma in Preschool Children A Pooled Analysis of Eight Birth Cohorts
- Article/chapterEnglish2012
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-315520
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-315520URI
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https://doi.org/10.1164/rccm.201203-0501OCDOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:125700684URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Rationale: Although epidemiological studies suggest that exposure to maternal smoking during fetal and early life increases the risk of childhood wheezing and asthma, previous studies were not able to differentiate the effects of prenatal from postnatal exposure. Objectives: To assess the effect of exposure to maternal smoking only during pregnancy on wheeze and asthma among preschool-age children. Methods: A pooled analysis was performed based on individual participant data from eight European birth cohorts. Cohort-specific effects of maternal smoking during pregnancy, but not during the first year, on wheeze and asthma at 4 to 6 years of age were estimated using logistic regression and then combined using a random effects model. Adjustments were made for sex, parental education, parental asthma, birth weight, and siblings. Measurements and Main Results: Among the 21,600 children included in the analysis, 735 children (3.4%) were exposed to maternal smoking exclusively during pregnancy but not in the first year after birth. In the pooled analysis, maternal smoking only during pregnancy was associated with wheeze and asthma at 4 to 6 years of age, with adjusted odds ratios of 1.39 (95% confidence interval, 1.08-1.77) and 1.65 (95% confidence interval, 1.18-2.31), respectively. The likelihood to develop wheeze and asthma increased statistically significantly in a linear dose-dependent manner in relation to maternal daily cigarette consumption during the first trimester of pregnancy. Conclusions: Maternal smoking during pregnancy appears to increase the risk of wheeze and asthma among children who are not exposed to maternal smoking after birth.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Hohmann, CynthiaCharite Univ Med Ctr, Inst Social Med Epidemiol & Hlth Econ, Berlin, Germany.
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Orsini, NicolaKarolinska Institutet
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Pershagen, GoranKarolinska Institutet
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Eller, EsbenOdense Univ Hosp, Dept Dermatol, DK-5000 Odense, Denmark.;Odense Univ Hosp, Allergy Ctr, DK-5000 Odense, Denmark.
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Kjaer, Henrik FomsgaardOdense Univ Hosp, Hans Christian Andersen Childrens Hosp, DK-5000 Odense, Denmark.
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Gehring, UlrikeUniv Utrecht, IRAS, Utrecht, Netherlands.
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Granell, RaquelUniv Bristol, Sch Social & Community Med, Bristol, Avon, England.
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Henderson, JohnUniv Bristol, Sch Social & Community Med, Bristol, Avon, England.
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Heinrich, JoachimGerman Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 1, Neuherberg, Germany.
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Lau, SusanneCharite Univ Med Ctr, Dept Pediat Pneumol & Immunol, Berlin, Germany.
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Nieuwenhuijsen, MarkCtr Res Environm Epidemiol CREAL, Barcelona, Spain.;CIBERESP, Barcelona, Spain.;IMIM Hosp del Mar Inst, Barcelona, Spain.
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Sunyer, JordiCtr Res Environm Epidemiol CREAL, Barcelona, Spain.;CIBERESP, Barcelona, Spain.;IMIM Hosp del Mar Inst, Barcelona, Spain.;UPF, Barcelona, Spain.
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Tischer, ChristinaGerman Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 1, Neuherberg, Germany.
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Torrent, MatiesCIBERESP, Barcelona, Spain.;Ib Salut, Area Salut Menorca, Palma De Mallorca, Spain.
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Wahn, UlrichCharite Univ Med Ctr, Dept Pediat Pneumol & Immunol, Berlin, Germany.
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Wijga, Alet H.Natl Inst Publ Hlth & Environm RIVM, Ctr Prevent & Hlth Serv Res, Bilthoven, Netherlands.
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Wickman, MagnusKarolinska Institutet
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Keil, ThomasCharite Univ Med Ctr, Inst Social Med Epidemiol & Hlth Econ, Berlin, Germany.
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Bergstrom, AnnaKarolinska Institutet
(author)
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the ENRICO, Consortium
(author)
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Uppsala universitetPediatrik
(creator_code:org_t)
Related titles
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In:American Journal of Respiratory and Critical Care Medicine186:10, s. 1037-10431073-449X1535-4970
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- By the author/editor
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Neuman, Åsa
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Hohmann, Cynthia
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Orsini, Nicola
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Pershagen, Goran
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Eller, Esben
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Kjaer, Henrik Fo ...
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show more...
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Gehring, Ulrike
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Granell, Raquel
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Henderson, John
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Heinrich, Joachi ...
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Lau, Susanne
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Nieuwenhuijsen, ...
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Sunyer, Jordi
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Tischer, Christi ...
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Torrent, Maties
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Wahn, Ulrich
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Wijga, Alet H.
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Wickman, Magnus
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Keil, Thomas
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Bergstrom, Anna
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the ENRICO, Cons ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
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MEDICAL AND HEAL ...
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Uppsala University
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Karolinska Institutet