Sökning: WFRF:(Ording Anne Gulbech) >
Hospital Recorded M...
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Ording, Anne GulbechAarhus Univ Hosp, Dept Clin Epidemiol, DK-8000 Aarhus, Denmark.
(författare)
Hospital Recorded Morbidity and Breast Cancer Incidence : A Nationwide Population-Based Case-Control Study
- Artikel/kapitelEngelska2012
Förlag, utgivningsår, omfång ...
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2012-10-19
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Public Library of Science (PLoS),2012
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-315527
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-315527URI
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https://doi.org/10.1371/journal.pone.0047329DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Introduction: Chronic diseases and their complications may increase breast cancer risk through known or still unknown mechanisms, or by shared causes. The association between morbidities and breast cancer risk has not been studied in depth. Methods: Data on all Danish women aged 45 to 85 years, diagnosed with breast cancer between 1994 and 2008 and data on preceding morbidities were retrieved from nationwide medical registries. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using conditional logistic regression associating the Charlson comorbidity score (measured using both the original and an updated Charlson Comorbidity Index (CCI)) with incident breast cancer. Furthermore, we estimated associations between 202 morbidity categories and incident breast cancer, adjusting for multiple comparisons using empirical Bayes (EB) methods. Results: The study included 46,324 cases and 463,240 population controls. Increasing CCI score, up to a score of six, was associated with slightly increased breast cancer risk. Among the Charlson diseases, preceding moderate to severe renal disease (OR = 1.25, 95% CI: 1.06, 1.48), any tumor (OR = 1.17, 95% CI: 1.10, 1.25), moderate to severe liver disease (OR = 1.86, 95% CI: 1.32, 2.62), and metastatic solid tumors (OR = 1.49, 95% CI: 1.17, 1.89), were most strongly associated with subsequent breast cancer. Preceding myocardial infarction (OR = 0.89, 95% CI: 0.81, 0.99), connective tissue disease (OR = 0.87, 95% CI: 0.80, 0.94), and ulcer disease (OR = 0.91, 95% CI: 0.83, 0.99) were most strongly inversely associated with subsequent breast cancer. A history of breast disorders was associated with breast cancer after EB adjustment. Anemias were inversely associated with breast cancer, but the association was near null after EB adjustment. Conclusions: There was no substantial association between morbidity measured with the CCI and breast cancer risk.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Garne, Jens PeterAarhus Univ Hosp, Aalborg Hosp, Breast Clin, DK-8000 Aarhus, Denmark.
(författare)
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Nyström, Petra Mariann WittUppsala universitet,Enheten för onkologi,Aarhus Univ Hosp, Aalborg Hosp, Dept Oncol, DK-8000 Aarhus, Denmark.(Swepub:uu)petwi362
(författare)
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Cronin-Fenton, DeirdreAarhus Univ Hosp, Dept Clin Epidemiol, DK-8000 Aarhus, Denmark.
(författare)
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Tarp, MajaAarhus Univ Hosp, Dept Clin Epidemiol, DK-8000 Aarhus, Denmark.
(författare)
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Sörensen, Henrik ToftAarhus Univ Hosp, Dept Clin Epidemiol, DK-8000 Aarhus, Denmark.
(författare)
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Lash, Timothy L.Aarhus Univ Hosp, Dept Clin Epidemiol, DK-8000 Aarhus, Denmark.;Wake Forest Sch Med, Dept Epidemiol & Prevent, Winston Salem, NC USA.
(författare)
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Aarhus Univ Hosp, Dept Clin Epidemiol, DK-8000 Aarhus, Denmark.Aarhus Univ Hosp, Aalborg Hosp, Breast Clin, DK-8000 Aarhus, Denmark.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:PLOS ONE: Public Library of Science (PLoS)7:101932-6203
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