Correlations between the enantio- and regio-selective metabolisms of warfarin

Takahashi, HarumiMeiji Pharmaceut Univ, Dept Biopharmaceut, Tokyo, Japan. (författare)

Aim: To clarify whether the activities of multiple CYPs associated with warfarin metabolism would be correlated with each other. Methods: Oral clearances (CLpo) of warfarin enantiomers were estimated in 378 Chinese, Caucasians and African-Americans. The partial metabolic clearances (CLm) for 7-hydroxywarfarin enantiomers were also measured. In addition, CLpo and CLm were determined in a patient on warfarin and rifampicin. Results: Correlations between CLpo for warfarin enantiomers existed across the three populations. In addition, there was a significant correlation between the CLm for 7-hydroxylation of warfarin enantiomers. Under induced conditions by rifampicin, there were significant correlations between the enantio-and regio-selective metabolisms of warfarin. Conclusion: Metabolic activities of CYP2C9, CYP1A2 and CYP3A4 may be regulated by common transcriptional mechanism(s).

Ohara, MinamiMeiji Pharmaceut Univ, Dept Biopharmaceut, Tokyo, Japan. (författare)
Shibata, SoichiKitasato Univ, Kitasato Inst Hosp, Dept Pharm, Tokyo, Japan. (författare)
Lee, Ming Ta MichaelGeisinger Hlth Syst, Danville, PA USA.;Acad Sinica, Inst Biomed Sci, Taipei, Taiwan. (författare)
Cavallari, Larisa H.Univ Florida, Dept Pharmacotherapy & Translat Res, Gainesville, FL USA.;Univ Florida, Ctr Pharmacogen, Gainesville, FL USA. (författare)
Nutescu, Edith A.Univ Illinois, Dept Pharm Practice, Chicago, IL USA. (författare)
Scordo, Maria GabriellaUppsala universitet,Klinisk farmakogenomik och osteoporos(Swepub:uu)gasco020 (författare)
Pengo, VittorioUniv Padua, Dept Cardiothorac & Vasc Sci, Padua, Italy. (författare)
Padrini, RobertoUniv Padua, Dept Med DIMED, Padua, Italy. (författare)
Atsuda, KoichiroKitasato Univ Hosp, Dept Pharm, Sagamihara, Kanagawa, Japan. (författare)
Matsubara, HajimeKitasato Univ, Kitasato Inst Hosp, Dept Pharm, Tokyo, Japan. (författare)
Chen, Yuan TsongAcad Sinica, Inst Biomed Sci, Taipei, Taiwan. (författare)
Echizen, HirotoshiMeiji Pharmaceut Univ, Dept Pharmacotherapy, Tokyo, Japan. (författare)
Meiji Pharmaceut Univ, Dept Biopharmaceut, Tokyo, Japan.Kitasato Univ, Kitasato Inst Hosp, Dept Pharm, Tokyo, Japan. (creator_code:org_t)

Ingår i:Pharmacogenomics (London): Future Medicine Ltd18:2, s. 133-1421462-24161744-8042

Av författaren/redakt...: Takahashi, Harum ...; Ohara, Minami; Shibata, Soichi; Lee, Ming Ta Mic ...; Cavallari, Laris ...; Nutescu, Edith A ...; visa fler...; Scordo, Maria Ga ...; Pengo, Vittorio; Padrini, Roberto; Atsuda, Koichiro; Matsubara, Hajim ...; Chen, Yuan Tsong; Echizen, Hirotos ...; visa färre...

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