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Associations betwee...
Associations between gender, disease features and symptom burden in patients with myeloproliferative neoplasms : an analysis by the MPN QOL International Working Group
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- Geyer, Holly L. (author)
- Mayo Clin, Dept Internal Med, Scottsdale, AZ 85259 USA.
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- Kosiorek, Heidi (author)
- Mayo Clin, Sect Biostat, Scottsdale, AZ USA.
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- Dueck, Amylou C. (author)
- Mayo Clin, Sect Biostat, Scottsdale, AZ USA.
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- Scherber, Robyn (author)
- Oregon Hlth & Sci Univ, Portland, OR USA.
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- Slot, Stefanie (author)
- Vrije Univ Amsterdam Med Ctr, Dept Hematol, Amsterdam, Netherlands.
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- Zweegman, Sonja (author)
- Vrije Univ Amsterdam Med Ctr, Dept Hematol, Amsterdam, Netherlands.
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- te Boekhorst, Peter A. W. (author)
- Erasmus MC, Dept Hematol, Rotterdam, Netherlands.
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- Senyak, Zhenya (author)
- MPN Forum, Asheville, NC USA.
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- Schouten, Harry C. (author)
- MUMC, Dept Hematol, Maastricht, Netherlands.
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- Sackmann, Federico (author)
- Fundaleu, Buenos Aires, DF, Argentina.
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- Kerguelen Fuentes, Ana (author)
- Univ Hosp La Paz, Dept Haematol, Madrid, Spain.
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- Hernandez-Maraver, Dolores (author)
- Univ Hosp La Paz, Dept Haematol, Madrid, Spain.
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- Pahl, Heike L. (author)
- Univ Hosp Freiburg, Dept Mol Hematol, Freiburg, Germany.
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- Griesshammer, Martin (author)
- Johannes Wesling Klinikum, Minden, Germany.
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- Stegelmann, Frank (author)
- Univ Hosp Ulm, Dept Internal Med 3, Ulm, Germany.
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- Doehner, Konstanze (author)
- Univ Hosp Ulm, Dept Internal Med 3, Ulm, Germany.
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- Lehmann, Thomas (author)
- Univ Hosp, Dept Hematol, Basel, Switzerland.
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- Bonatz, Karin (author)
- Univ Med, Med Klin, Mannheim, Germany.
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- Reiter, Andreas (author)
- Univ Med, Med Klin, Mannheim, Germany.
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- Boyer, Francoise (author)
- Ctr Hosp Univ, Angers, France.
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- Etienne, Gabriel (author)
- Inst Bergonie, Bordeaux, France.
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- Ianotto, Jean-Christophe (author)
- Ctr Hosp Univ, Brest, France.
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- Ranta, Dana (author)
- Hosp Univ, Nancy, France.
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- Roy, Lydia (author)
- Ctr Hosp Univ, Poitiers, France.
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- Cahn, Jean-Yves (author)
- Ctr Hosp Univ, Grenoble, France.
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- Harrison, Claire N. (author)
- Guys & St Thomas NHS Fdn Trust, Dept Haematol, London, England.
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- Radia, Deepti (author)
- Guys & St Thomas NHS Fdn Trust, Dept Haematol, London, England.
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- Muxi, Pablo (author)
- Hosp Britan, Unidadde Hematol, Montevideo, Uruguay.
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- Maldonado, Norman (author)
- Univ Puerto Rico, Sch Med, San Juan, PR 00936 USA.
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- Besses, Carlos (author)
- Hosp del Mar, Dept Hematol, Barcelona, Spain.
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- Cervantes, Francisco (author)
- Univ Barcelona, Hosp Clin, Dept Hematol, IDIBAPS, Barcelona, Spain.
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- Johansson, Peter L. (author)
- NU Hosp Org, Internal Med, Uddevalla, Sweden.
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- Barbui, Tiziano (author)
- Hosp Papa Giovanni XXIII, Res Fdn FROM, Bergamo, Italy.
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- Barosi, Giovanni (author)
- IRCCS Policlin S Matteo Fdn, Lab Clin Epidemiol, Pavia, Italy.
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- Vannucchi, Alessandro M. (author)
- Univ Florence, Ctr Res & Innovat Myeloproliferat Neoplasms, Florence, Italy.
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- Paoli, Chiara (author)
- Univ Florence, Ctr Res & Innovat Myeloproliferat Neoplasms, Florence, Italy.
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- Passamonti, Francesco (author)
- Univ Insubria, Dipartimento Med Clin & Sperimentale, Ematol, Varese, Italy.
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- Andreasson, Bjorn (author)
- NU Hosp Org, Internal Med, Uddevalla, Sweden.
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- Ferrari, Maria L. (author)
- Osped Riuniti Bergamo, Biol Sci, Bergamo, Italy.
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- Rambaldi, Alessandro (author)
- Hosp Papa Giovanni XXIII, Res Fdn FROM, Bergamo, Italy.
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- Samuelsson, Jan (author)
- Karolinska Institutet
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- Cannon, Keith (author)
- Mayo Clin, Dept Internal Med, Scottsdale, AZ 85259 USA.
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- Birgegård, Gunnar (author)
- Uppsala universitet,Hematologi
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- Xiao, Zhijian (author)
- Chinese Acad Med Sci, Inst Hematol, MDS & MPN Ctr, Tianjin, Peoples R China.;Chinese Acad Med Sci, Blood Dis Hosp, Tianjin, Peoples R China.;Peking Union Med Coll, Tianjin, Peoples R China.
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- Xu, Zefeng (author)
- Chinese Acad Med Sci, Inst Hematol, MDS & MPN Ctr, Tianjin, Peoples R China.;Chinese Acad Med Sci, Blood Dis Hosp, Tianjin, Peoples R China.;Peking Union Med Coll, Tianjin, Peoples R China.
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- Zhang, Yue (author)
- Chinese Acad Med Sci, Inst Hematol, MDS & MPN Ctr, Tianjin, Peoples R China.;Chinese Acad Med Sci, Blood Dis Hosp, Tianjin, Peoples R China.;Peking Union Med Coll, Tianjin, Peoples R China.
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- Sun, Xiujuan (author)
- Chinese Acad Med Sci, Inst Hematol, MDS & MPN Ctr, Tianjin, Peoples R China.;Chinese Acad Med Sci, Blood Dis Hosp, Tianjin, Peoples R China.;Peking Union Med Coll, Tianjin, Peoples R China.
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- Xu, Junqing (author)
- Chinese Acad Med Sci, Inst Hematol, MDS & MPN Ctr, Tianjin, Peoples R China.;Chinese Acad Med Sci, Blood Dis Hosp, Tianjin, Peoples R China.;Peking Union Med Coll, Tianjin, Peoples R China.
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- Kiladjian, Jean-Jacques (author)
- Hosp St Louis, Clin Invest Ctr, Paris, France.
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- Zhang, Peihong (author)
- Chinese Acad Med Sci, Blood Dis Hosp, Tianjin, Peoples R China.;Peking Union Med Coll, Tianjin, Peoples R China.;Chinese Acad Med Sci, Inst Hematol, Dept Pathol, Tianjin, Peoples R China.
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- Gale, Robert Peter (author)
- Imperial Coll, London, England.
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- Mesa, Ruben A. (author)
- Mayo Clin, Dept Hematol & Oncol, Scottsdale, AZ 85259 USA.
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Mayo Clin, Dept Internal Med, Scottsdale, AZ 85259 USA Mayo Clin, Sect Biostat, Scottsdale, AZ USA. (creator_code:org_t)
- 2016-08-18
- 2017
- English.
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In: Haematologica. - : Ferrata Storti Foundation (Haematologica). - 0390-6078 .- 1592-8721. ; 102:1, s. 85-93
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Abstract
Subject headings
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- The myeloproliferative neoplasms, including polycythemia vera, essential thrombocythemia and myelofibrosis, are distinguished by their debilitating symptom profiles, life-threatening complications and profound impact on quality of life. The role gender plays in the symptomatology of myeloproliferative neoplasms remains under-investigated. In this study we evaluated how gender relates to patients' characteristics, disease complications and overall symptom expression. A total of 2,006 patients (polycythemia vera=711, essential thrombocythemia=830, myelofibrosis=460, unknown=5) were prospectively evaluated, with patients completing the Myeloproliferative Neoplasm-Symptom Assessment Form and Brief Fatigue Inventory Patient Reported Outcome tools. Information on the individual patients' characteristics, disease complications and laboratory data was collected. Consistent with known literature, most female patients were more likely to have essential thrombocythemia (48.6% versus 33.0%; P<0.001) and most male patients were more likely to have polycythemia vera (41.8% versus 30.3%; P<0.001). The rate of thrombocytopenia was higher among males than females (13.9% versus 8.2%; P<0.001) and males also had greater red-blood cell transfusion requirements (7.3% versus 4.9%; P=0.02) with shorter mean disease duration (6.4 versus 7.2 years, P=0.03). Despite there being no statistical differences in risk scores, receipt of most therapies or prior complications (hemorrhage, thrombosis), females had more severe and more frequent symptoms for most individual symptoms, along with overall total symptom score (22.8 versus 20.3; P<0.001). Females had particularly high scores for abdominal-related symptoms (abdominal pain/discomfort) and microvascular symptoms (headache, fatigue, insomnia, concentration difficulties, dizziness; all P<0.01). Despite complaining of more severe symptom burden, females had similar quality of life scores to those of males. The results of this study suggest that gender contributes to the heterogeneity of myeloproliferative neoplasms by influencing phenotypic profiles and symptom expression.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Geyer, Holly L.
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Kosiorek, Heidi
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Dueck, Amylou C.
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Scherber, Robyn
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Slot, Stefanie
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Zweegman, Sonja
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show more...
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te Boekhorst, Pe ...
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Senyak, Zhenya
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Schouten, Harry ...
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Sackmann, Federi ...
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Kerguelen Fuente ...
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Hernandez-Marave ...
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Pahl, Heike L.
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Griesshammer, Ma ...
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Stegelmann, Fran ...
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Doehner, Konstan ...
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Lehmann, Thomas
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Bonatz, Karin
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Reiter, Andreas
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Boyer, Francoise
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Etienne, Gabriel
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Ianotto, Jean-Ch ...
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Ranta, Dana
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Roy, Lydia
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Cahn, Jean-Yves
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Harrison, Claire ...
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Radia, Deepti
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Muxi, Pablo
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Maldonado, Norma ...
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Besses, Carlos
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Cervantes, Franc ...
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Johansson, Peter ...
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Barbui, Tiziano
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Barosi, Giovanni
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Vannucchi, Aless ...
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Paoli, Chiara
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Passamonti, Fran ...
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Andreasson, Bjor ...
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Ferrari, Maria L ...
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Rambaldi, Alessa ...
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Samuelsson, Jan
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Cannon, Keith
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Birgegård, Gunna ...
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Xiao, Zhijian
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Xu, Zefeng
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Zhang, Yue
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Sun, Xiujuan
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Xu, Junqing
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Kiladjian, Jean- ...
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Zhang, Peihong
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Gale, Robert Pet ...
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Mesa, Ruben A.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Haematologica
- By the university
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Uppsala University
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Karolinska Institutet