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The Impact of Local...
The Impact of Local Control in the Treatment of Type II/III Pleuropulmonary Blastoma. Experience of the Cooperative Weichteilsarkom Studiengruppe (CWS)
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- Sparber-Sauer, Monika (author)
- Olga Hosp, Klinikum Stuttgart, Zentrum Kinder Jugend & Frauenmed, Pediat Pediat Oncol 5,Hematol,Immunol, Stuttgart, Germany.
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- Seitz, Guido (author)
- Univ Childrens Hosp, Dept Pediat Surg, Marburg, Germany.
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- Kirsch, Sylvia (author)
- Olga Hosp, Klinikum Stuttgart, Zentrum Kinder Jugend & Frauenmed, Pediat Pediat Oncol 5,Hematol,Immunol, Stuttgart, Germany.;Kinder & Jugendarztpraxis Dr Konstatopoulos, Munich, Germany.
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- Vokuhl, Christian (author)
- Univ Kiel, Inst Paidopathol, Kiel, Germany.
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- Leuschner, Ivo (author)
- Univ Kiel, Inst Paidopathol, Kiel, Germany.
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- Dantonello, Tobias M. (author)
- Olga Hosp, Klinikum Stuttgart, Zentrum Kinder Jugend & Frauenmed, Pediat Pediat Oncol 5,Hematol,Immunol, Stuttgart, Germany.
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- Scheer, Monika (author)
- Olga Hosp, Klinikum Stuttgart, Zentrum Kinder Jugend & Frauenmed, Pediat Pediat Oncol 5,Hematol,Immunol, Stuttgart, Germany.
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- von Kalle, Thekla (author)
- Olga Hosp, Klinikum Stuttgart, Zentrum Kinder Jugend & Frauenmed, Inst Radiol, Stuttgart, Germany.
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- Ljungman, Gustaf (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa
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- Bielack, Stefan S. (author)
- Olga Hosp, Klinikum Stuttgart, Zentrum Kinder Jugend & Frauenmed, Pediat Pediat Oncol 5,Hematol,Immunol, Stuttgart, Germany.;Univ Munster, Dept Pediat Hematol & Oncol, Munster, Germany.
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- Klingebiel, Thomas (author)
- Goethe Univ Frankfurt, Hosp Children & Adolescents, Frankfurt, Germany.
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- Fuchs, Joerg (author)
- Univ Childrens Hosp, Dept Pediat Surg & Urol, Tubingen, Germany.
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- Koscielniak, Ewa (author)
- Olga Hosp, Klinikum Stuttgart, Zentrum Kinder Jugend & Frauenmed, Pediat Pediat Oncol 5,Hematol,Immunol, Stuttgart, Germany.;Univ Childrens Hosp, Dept Pediat Hematol & Oncol, Tubingen, Germany.
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Olga Hosp, Klinikum Stuttgart, Zentrum Kinder Jugend & Frauenmed, Pediat Pediat Oncol 5,Hematol,Immunol, Stuttgart, Germany Univ Childrens Hosp, Dept Pediat Surg, Marburg, Germany. (creator_code:org_t)
- 2017-01-19
- 2017
- English.
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In: Journal of Surgical Oncology. - : Wiley. - 0022-4790 .- 1096-9098. ; 115:2, s. 164-172
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background and Objectives: This study aims at examining the potential survival benefits of primary versus secondary surgery in the management of children diagnosed with pleuropulmonary blastoma (PPB) type II/III.Patients and Methods: Disease characteristics, treatment, and survival of 29 children with localized PPB type II/III, treated in six prospective Cooperative Weichteilsarkom Studiengruppe (CWS) trials, were reviewed retrospectively.Results: Five year event free survival (EFS) and overall survival (OS) of children treated according to CWS protocols was 72%. Patients with tumors <= 10 cm had a 5 year OS of 91% versus 57% in patients with tumors > 10 cm (P = 0.025). Five year OS of patients with macroscopically incomplete upfront resections was 44% as opposed to 68% in patients with delayed/secondary microscopically or macroscopically complete resection after an initial biopsy (P = 0.476). Ten patients died of disease, one patient died of second malignancy. Tumor size and complete tumor resection at any time were significant prognostic factors (P = 0.025/0.003) for EFS. EFS for microscopically complete, microscopically incomplete, and macroscopically incomplete resection at any time was 91%, 90%, and 25%, respectively (P = 0.01).Conclusions: Primary or secondary microscopically/macroscopically complete tumor resections in combination with chemotherapy correlates with long term survival in children with PPB.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Pediatric oncology
- pleuropulmonary blastoma
- thoracic tumor
- CWS Studiengruppe
- surgery
Publication and Content Type
- ref (subject category)
- art (subject category)
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Sparber-Sauer, M ...
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Seitz, Guido
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Kirsch, Sylvia
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Vokuhl, Christia ...
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Leuschner, Ivo
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Dantonello, Tobi ...
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Scheer, Monika
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von Kalle, Thekl ...
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Ljungman, Gustaf
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Bielack, Stefan ...
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Klingebiel, Thom ...
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Fuchs, Joerg
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Koscielniak, Ewa
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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Journal of Surgi ...
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Uppsala University