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Genome-wide associa...
Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.
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Wain, Louise V (author)
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Shrine, Nick (author)
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Artigas, María Soler (author)
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Erzurumluoglu, A Mesut (author)
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Noyvert, Boris (author)
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Bossini-Castillo, Lara (author)
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Obeidat, Ma'en (author)
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Henry, Amanda P (author)
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Portelli, Michael A (author)
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Hall, Robert J (author)
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Billington, Charlotte K (author)
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Rimington, Tracy L (author)
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Fenech, Anthony G (author)
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John, Catherine (author)
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Blake, Tineka (author)
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Jackson, Victoria E (author)
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Allen, Richard J (author)
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Prins, Bram P (author)
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Campbell, Archie (author)
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Porteous, David J (author)
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Jarvelin, Marjo-Riitta (author)
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Wielscher, Matthias (author)
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James, Alan L (author)
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Hui, Jennie (author)
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Wareham, Nicholas J (author)
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Zhao, Jing Hua (author)
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Wilson, James F (author)
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Joshi, Peter K (author)
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Stubbe, Beate (author)
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Rawal, Rajesh (author)
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Schulz, Holger (author)
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Imboden, Medea (author)
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Probst-Hensch, Nicole M (author)
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Karrasch, Stefan (author)
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Gieger, Christian (author)
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Deary, Ian J (author)
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Harris, Sarah E (author)
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Marten, Jonathan (author)
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Rudan, Igor (author)
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- Enroth, Stefan (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
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- Gyllensten, Ulf B. (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
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Kerr, Shona M (author)
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Polasek, Ozren (author)
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Kähönen, Mika (author)
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Surakka, Ida (author)
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Vitart, Veronique (author)
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Hayward, Caroline (author)
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Lehtimäki, Terho (author)
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Raitakari, Olli T (author)
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Evans, David M (author)
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Henderson, A John (author)
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Pennell, Craig E (author)
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Wang, Carol A (author)
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Sly, Peter D (author)
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Wan, Emily S (author)
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Busch, Robert (author)
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Hobbs, Brian D (author)
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Litonjua, Augusto A (author)
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Sparrow, David W (author)
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Gulsvik, Amund (author)
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Bakke, Per S (author)
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Crapo, James D (author)
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Beaty, Terri H (author)
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Hansel, Nadia N (author)
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Mathias, Rasika A (author)
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Ruczinski, Ingo (author)
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Barnes, Kathleen C (author)
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Bossé, Yohan (author)
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Joubert, Philippe (author)
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van den Berge, Maarten (author)
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Brandsma, Corry-Anke (author)
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Paré, Peter D (author)
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Sin, Don D (author)
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Nickle, David C (author)
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Hao, Ke (author)
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Gottesman, Omri (author)
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Dewey, Frederick E (author)
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Bruse, Shannon E (author)
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Carey, David J (author)
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Kirchner, H Lester (author)
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Jonsson, Stefan (author)
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Thorleifsson, Gudmar (author)
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Jonsdottir, Ingileif (author)
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Gislason, Thorarinn (author)
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Stefansson, Kari (author)
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Schurmann, Claudia (author)
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Nadkarni, Girish (author)
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Bottinger, Erwin P (author)
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Loos, Ruth J F (author)
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Walters, Robin G (author)
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Chen, Zhengming (author)
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Millwood, Iona Y (author)
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Vaucher, Julien (author)
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Kurmi, Om P (author)
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Li, Liming (author)
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Hansell, Anna L (author)
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Brightling, Chris (author)
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Zeggini, Eleftheria (author)
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Cho, Michael H (author)
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Silverman, Edwin K (author)
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Sayers, Ian (author)
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Trynka, Gosia (author)
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Morris, Andrew P (author)
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Strachan, David P (author)
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Hall, Ian P (author)
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Tobin, Martin D (author)
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(creator_code:org_t)
- 2017-02-06
- 2017
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 49:3, s. 416-425
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function and is the third leading cause of death globally. Through genome-wide association discovery in 48,943 individuals, selected from extremes of the lung function distribution in UK Biobank, and follow-up in 95,375 individuals, we increased the yield of independent signals for lung function from 54 to 97. A genetic risk score was associated with COPD susceptibility (odds ratio per 1 s.d. of the risk score (∼6 alleles) (95% confidence interval) = 1.24 (1.20-1.27), P = 5.05 × 10(-49)), and we observed a 3.7-fold difference in COPD risk between individuals in the highest and lowest genetic risk score deciles in UK Biobank. The 97 signals show enrichment in genes for development, elastic fibers and epigenetic regulation pathways. We highlight targets for drugs and compounds in development for COPD and asthma (genes in the inositol phosphate metabolism pathway and CHRM3) and describe targets for potential drug repositioning from other clinical indications.
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- art (subject category)
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- By the author/editor
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Wain, Louise V
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Shrine, Nick
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Artigas, María S ...
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Erzurumluoglu, A ...
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Noyvert, Boris
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Bossini-Castillo ...
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show more...
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Obeidat, Ma'en
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Henry, Amanda P
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Portelli, Michae ...
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Hall, Robert J
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Billington, Char ...
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Rimington, Tracy ...
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Fenech, Anthony ...
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John, Catherine
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Blake, Tineka
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Jackson, Victori ...
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Allen, Richard J
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Prins, Bram P
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Campbell, Archie
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Porteous, David ...
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Jarvelin, Marjo- ...
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Wielscher, Matth ...
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James, Alan L
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Hui, Jennie
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Wareham, Nichola ...
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Zhao, Jing Hua
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Wilson, James F
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Joshi, Peter K
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Stubbe, Beate
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Rawal, Rajesh
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Schulz, Holger
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Imboden, Medea
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Probst-Hensch, N ...
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Karrasch, Stefan
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Gieger, Christia ...
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Deary, Ian J
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Harris, Sarah E
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Marten, Jonathan
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Rudan, Igor
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Enroth, Stefan
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Gyllensten, Ulf ...
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Kerr, Shona M
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Polasek, Ozren
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Kähönen, Mika
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Surakka, Ida
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Vitart, Veroniqu ...
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Hayward, Carolin ...
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Lehtimäki, Terho
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Raitakari, Olli ...
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Evans, David M
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Henderson, A Joh ...
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Pennell, Craig E
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Wang, Carol A
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Sly, Peter D
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Wan, Emily S
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Busch, Robert
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Hobbs, Brian D
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Litonjua, August ...
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Sparrow, David W
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Gulsvik, Amund
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Bakke, Per S
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Crapo, James D
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Beaty, Terri H
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Hansel, Nadia N
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Mathias, Rasika ...
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Ruczinski, Ingo
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Barnes, Kathleen ...
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Bossé, Yohan
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Joubert, Philipp ...
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van den Berge, M ...
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Brandsma, Corry- ...
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Paré, Peter D
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Sin, Don D
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Nickle, David C
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Hao, Ke
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Gottesman, Omri
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Dewey, Frederick ...
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Bruse, Shannon E
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Carey, David J
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Kirchner, H Lest ...
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Jonsson, Stefan
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Thorleifsson, Gu ...
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Jonsdottir, Ingi ...
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Gislason, Thorar ...
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Stefansson, Kari
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Schurmann, Claud ...
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Nadkarni, Girish
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Bottinger, Erwin ...
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Loos, Ruth J F
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Walters, Robin G
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Chen, Zhengming
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Millwood, Iona Y
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Vaucher, Julien
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Kurmi, Om P
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Li, Liming
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Hansell, Anna L
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Brightling, Chri ...
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Zeggini, Elefthe ...
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Cho, Michael H
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Silverman, Edwin ...
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Sayers, Ian
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Trynka, Gosia
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Morris, Andrew P
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Strachan, David ...
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Hall, Ian P
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Tobin, Martin D
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- Articles in the publication
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Nature Genetics
- By the university
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Uppsala University