Search: WFRF:(Winqvist Ola) >
Clinical and immuno...
Clinical and immunological characteristics of Autoimmune Addison's disease : a nationwide Swedish multicenter study
-
- Dalin, Frida, 1984- (author)
- Uppsala University,Karolinska Institutet,Uppsala universitet,Dermatologi och venereologi,Science for Life Laboratory, SciLifeLab,Karolinska Inst, Ctr Mol Med, Dept Med Solna, SE-17176 Stockholm, Sweden,Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Karolinska Institutet, Stockholm, Sweden, Uppsala University, Uppsala, Sweden
-
- Nordling Eriksson, Gabriel (author)
- Karolinska Institutet,Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Dept Mol Med & Surg, SE-17176 Stockholm, Sweden
-
- Dahlqvist, Per (author)
- Umeå universitet,Umeå University,Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Medicin,Umea Univ, Dept Publ Hlth & Clin Med, SE-90736 Umea, Sweden,Umeå University, Umeå, Sweden
-
show more...
-
- Hallgren, Åsa (author)
- Karolinska Institutet,Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Ctr Mol Med, Dept Med Solna, SE-17176 Stockholm, Sweden
-
- Wahlberg, Jeanette, 1969- (author)
- Linköpings universitet,Linköping University,Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Linkoping Univ, Div Endocrinol, Dept Med & Hlth Sci, Fac Hlth Sci, SE-58183 Linkoping, Sweden,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Endokrinmedicinska kliniken
-
- Ekwall, Olov, 1968 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Clinical Sciences, Department of Pediatrics,Institute of Medicine, Department of Rheumatology and Inflammation Research,Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Linkoping Univ, Div Pediat, Dept Clin & Expt Med, SE-58183 Linkoping, Sweden,The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
-
- Söderberg, Stefan (author)
- Karolinska Institutet,Umeå universitet,Umeå University,Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Kardiologi,Umea Univ, Dept Publ Hlth & Clin Med, SE-90736 Umea, Sweden,Umeå University, Umeå, Sweden
-
- Rönnelid, Johan (author)
- Uppsala University,Uppsala universitet,Klinisk immunologi,Johan Rönnelid,Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
-
- Olcén, Per (author)
- Örebro University,Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Univ Orebro, Dept Lab Med, SE-70281 Orebro, Sweden,Örebro University, Örebro, Sweden
-
- Winqvist, Ola (author)
- Karolinska Institutet,Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Karolinska Univ Hosp, Translat Immunol, Dept Med Solna, SE-17176 Stockholm, Sweden
-
- Catrina, Sergiu-Bogdan (author)
- Karolinska Institutet,Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Karolinska Univ Hosp, Dept Endocrinol Metab & Diabet, SE-17176 Stockholm, Sweden
-
- Kriström, Berit (author)
- Umeå universitet,Umeå University,Umeå University, Umeå , Sweden,Pediatrik,Umea Univ, Inst Clin Sci, Pediat, SE-90736 Umea, Sweden
-
- Laudius, Maria (author)
- Umeå universitet,Umeå University,Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Avdelningen för medicin,Umea Univ, Dept Publ Hlth & Clin Med, SE-90736 Umea, Sweden,Umeå University, Umeå, Sweden
-
- Isaksson, Magnus (author)
- Uppsala University,Uppsala universitet,Autoimmunitet,Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Uppsala University, Uppsala, Sweden
-
- Halldin Stenlid, Maria, 1957- (author)
- Uppsala University,Uppsala universitet,Pediatrisk inflammationsforskning,Uppsala University, Uppsala, Sweden
-
- Gustafsson, Jan, 1948- (author)
- Uppsala University,Uppsala universitet,Pediatrisk inflammationsforskning,Uppsala University, Uppsala, Sweden
-
- Gebre-Medhin, Gennet (author)
- Uppsala University,Uppsala universitet,Pediatrisk inflammationsforskning,Uppsala University, Uppsala, Sweden
-
- Björnsdottir, Sigridur (author)
- Karolinska Institutet,Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Dept Mol Med & Surg, SE-17176 Stockholm, Sweden; Karolinska Inst, Karolinska Univ Hosp, Dept Endocrinol Metab & Diabet, SE-17176 Stockholm, Sweden,Karolinska In Karolinska University Hospital, Stockholm, Sweden
-
- Janson, Annika (author)
- Karolinska Institutet,Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Dept Womens & Childrens Hlth, SE-17176 Stockholm, Sweden
-
- Åkerman, Anna-Karin (author)
- Karolinska Institutet,Örebro University,Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Univ Orebro, Dept Lab Med, SE-70281 Orebro, Sweden,Örebro University, Örebro, Sweden
-
- Åman, Jan (author)
- Örebro University,Department of Pediatrics, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Univ Orebro, Dept Pediat, Fac Med & Hlth, SE-70281 Orebro, Sweden
-
- Duchen, Karel (author)
- Linköpings universitet,Linköping University,Linköping University, Linköping, Sweden,Linkoping Univ, Div Pediat, Dept Clin & Expt Med, SE-58183 Linkoping, Sweden,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Barn- och ungdomskliniken i Linköping
-
- Bergthorsdottir, Ragnhildur, 1971 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden; Sahlgrenska University Hospital, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Univ Gothenburg, Inst Med, SE-40530 Gothenburg, Sweden; Univ Gothenburg, Dept Endocrinol, Sahlgrenska Univ Hosp, Sahlgrenska Acad, SE-40530 Gothenburg, Sweden
-
- Johannsson, Gudmundur, 1960 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden; Sahlgrenska University Hospital, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Univ Gothenburg, Inst Med, SE-40530 Gothenburg, Sweden; Univ Gothenburg, Dept Endocrinol, Sahlgrenska Univ Hosp, Sahlgrenska Acad, SE-40530 Gothenburg, Sweden
-
- Lindskog, Emma (author)
- University of Gothenburg,Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Univ Gothenburg, Dept Pediat, Inst Clin Sci, SE-40530 Gothenburg, Sweden,The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
-
- Landin-Olsson, Mona (author)
- Skane Univ Hosp, Dept Endocrinol, SE-22362 Lund, Sweden,Skåne University Hospital, Lund, Sweden,Skåne University Hospital, Malmö, Sweden.
-
- Elfving, Maria (author)
- Lund University,Lunds universitet,Childhood Cancer Research Unit,Forskargrupper vid Lunds universitet,Lund University Research Groups,Lund University, Lund, Sweden.,Lund Univ, Dept Pediat, Pediat Endocrinol, Clin Sci, SE-22362 Lund, Sweden
-
- Waldenström, Erik (author)
- Skane Univ Hosp, Dept Endocrinol, SE-22362 Lund, Sweden,Skåne University Hospital, Lund, Sweden,Skåne University Hospital, Malmö, Sweden
-
- Hulting, Anna-Lena (author)
- Karolinska Institutet,Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Dept Mol Med & Surg, SE-17176 Stockholm, Sweden
-
- Kämpe, Olle (author)
- Karolinska Institutet,Karolinska University Hospital, Stockholm, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Ctr Mol Med, Dept Med Solna, SE-17176 Stockholm, Sweden; Karolinska Inst, Karolinska Univ Hosp, Dept Endocrinol Metab & Diabet, SE-17176 Stockholm, Sweden
-
- Bensing, Sophie (author)
- Karolinska Institutet,Karolinska University Hospital, Stockholm, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Dept Mol Med & Surg, SE-17176 Stockholm, Sweden; Karolinska Inst, Karolinska Univ Hosp, Dept Endocrinol Metab & Diabet, SE-17176 Stockholm, Sweden
-
show less...
-
(creator_code:org_t)
- 2016-11-21
- 2017
- English.
-
In: Journal of Clinical Endocrinology and Metabolism. - : Oxford University Press. - 0021-972X .- 1945-7197. ; 102:2, s. 379-389
- Related links:
-
https://academic.oup...
-
show more...
-
http://dx.doi.org/10...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
https://gup.ub.gu.se...
-
https://urn.kb.se/re...
-
https://urn.kb.se/re...
-
http://kipublication...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- CONTEXT: Studies on clinical and immunological features of Autoimmune Addison's disease (AAD) are needed to understand the disease burden and increased mortality.OBJECTIVE: To provide upgraded data on autoimmune comorbidities, replacement therapy, autoantibody profiles and cardiovascular risk factors.DESIGN, SETTING AND PARTICIPANTS: Cross sectional, population-based study. 660 AAD patients were included utilizing the Swedish Addison Registry (SAR) 2008-2014. When analyzing cardiovascular risk factors, 3,594 individuals from the population-based survey in Northern Sweden, MONICA (MONItoring of Trends and Determinants of CArdiovascular Disease), served as controls.MAIN OUTCOME MEASURE: Prevalence of autoimmune comorbidities and cardiovascular risk factors. Autoantibodies against 13 autoantigens were determined.RESULTS: Sixty percent of the SAR cohort consisted of females. Mean age at diagnosis was significantly higher for females than for males (36.8 vs. 31.1 years). The proportion of 21-hydroxylase autoantibody positive patients was 83% and 62% of patients had one or more associated autoimmune diseases, more frequently coexisting in females (p<0.0001). AAD patients had lower BMI (p<0.0001) and prevalence of hypertension (p=0.027) compared with controls. Conventional hydrocortisone tablets were used by 89% of patients; with the mean dose 28.1±8.5 mg/day. The mean hydrocortisone equivalent dose normalized to body surface was 14.8±4.4 mg/m(2)/day. Higher hydrocortisone equivalent dose was associated with higher incidence of hypertension (p=0.046).CONCLUSIONS: Careful monitoring of AAD patients is warranted to detect associated autoimmune diseases. Contemporary Swedish AAD patients do not have increased prevalence of overweight, hypertension, T2DM or hyperlipidemia. However, high glucocorticoid replacement doses may be a risk factor for hypertension.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Endocrinology and Diabetology
- Endokrinologi och Diabetologi
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Dalin, Frida, 19 ...
-
Nordling Eriksso ...
-
Dahlqvist, Per
-
Hallgren, Åsa
-
Wahlberg, Jeanet ...
-
Ekwall, Olov, 19 ...
-
show more...
-
Söderberg, Stefa ...
-
Rönnelid, Johan
-
Olcén, Per
-
Winqvist, Ola
-
Catrina, Sergiu- ...
-
Kriström, Berit
-
Laudius, Maria
-
Isaksson, Magnus
-
Halldin Stenlid, ...
-
Gustafsson, Jan, ...
-
Gebre-Medhin, Ge ...
-
Björnsdottir, Si ...
-
Janson, Annika
-
Åkerman, Anna-Ka ...
-
Åman, Jan
-
Duchen, Karel
-
Bergthorsdottir, ...
-
Johannsson, Gudm ...
-
Lindskog, Emma
-
Landin-Olsson, M ...
-
Elfving, Maria
-
Waldenström, Eri ...
-
Hulting, Anna-Le ...
-
Kämpe, Olle
-
Bensing, Sophie
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Endocrinology an ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Rheumatology and ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
- Articles in the publication
-
Journal of Clini ...
- By the university
-
Uppsala University
-
Lund University
-
University of Gothenburg
-
Örebro University
-
Umeå University
-
Karolinska Institutet
-
show more...
-
Linköping University
-
show less...