Sökning: (WFRF:(Zompo Maria Del))
> (2015-2019) >
High leptin levels ...
High leptin levels are associated with migraine with aura
-
- Pisanu, Claudia (författare)
- Uppsala universitet,Funktionell farmakologi,Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
-
- Preisig, Martin (författare)
- Department of Psychiatry, Lausanne University Hospital, Prilly, Switzerland.
-
- Castelao, Enrique (författare)
- Department of Psychiatry, Lausanne University Hospital, Prilly, Switzerland.
-
visa fler...
-
- Glaus, Jennifer (författare)
- Genetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA.
-
- Cunningham, Janet L. (författare)
- Uppsala universitet,Psykiatri, Akademiska sjukhuset
-
- Del Zompo, Maria (författare)
- Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
-
- Merikangas, Kathleen R. (författare)
- Genetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA.
-
- Schiöth, Helgi B. (författare)
- Uppsala universitet,Funktionell farmakologi
-
- Mwinyi, Jessica (författare)
- Uppsala universitet,Funktionell farmakologi
-
visa färre...
-
(creator_code:org_t)
- 2016-05-10
- 2017
- Engelska.
-
Ingår i: Cephalalgia. - : SAGE Publications. - 0333-1024 .- 1468-2982. ; 37:5, s. 435-441
- Relaterad länk:
-
https://serval.unil....
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND: Migraine is a prevalent disorder characterised by recurrent headache attacks preceded or accompanied by aura in a subgroup of patients. Migraine often occurs together with major depressive disorder (MDD). Alterations of adipokine levels have been reported both in migraine and in MDD. In this cross-sectional study, we aimed to assess the associations between serum leptin and adiponectin levels and migraine or migraine subtypes. Analyses were adjusted for a lifetime history of MDD in order to investigate the association between adipokines and migraine under consideration of depression status.METHODS: We included 3025 participants from the CoLaus/PsyCoLaus study. The impact of leptin and adiponectin levels on a diagnosis of migraine was analysed by binary regression analyses, adjusting for variables known to influence adipokine levels. Subgroup analyses were conducted based on the presence of aura.RESULTS: Crude leptin levels were significantly higher in subjects with migraine than controls (Mann-Whitney U = 515,102, p = 6 × 10(-7)). When performing adjusted analyses, leptin levels were found to be significantly higher in subjects with migraine (odds ratio = 1.22, p = 0.024) and migraine with aura (odds ratio = 1.34, p = 0.004).CONCLUSION: High leptin levels might play a role in the pathogenesis of migraine and migraine with aura.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Migraine
- adiponectin
- aura
- leptin
- major depressive disorder
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas