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High leptin levels ...
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Pisanu, ClaudiaUppsala universitet,Funktionell farmakologi,Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
(author)
High leptin levels are associated with migraine with aura
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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2016-05-10
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SAGE Publications,2017
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Numbers
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LIBRIS-ID:oai:DiVA.org:uu-318574
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-318574URI
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https://doi.org/10.1177/0333102416648650DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND: Migraine is a prevalent disorder characterised by recurrent headache attacks preceded or accompanied by aura in a subgroup of patients. Migraine often occurs together with major depressive disorder (MDD). Alterations of adipokine levels have been reported both in migraine and in MDD. In this cross-sectional study, we aimed to assess the associations between serum leptin and adiponectin levels and migraine or migraine subtypes. Analyses were adjusted for a lifetime history of MDD in order to investigate the association between adipokines and migraine under consideration of depression status.METHODS: We included 3025 participants from the CoLaus/PsyCoLaus study. The impact of leptin and adiponectin levels on a diagnosis of migraine was analysed by binary regression analyses, adjusting for variables known to influence adipokine levels. Subgroup analyses were conducted based on the presence of aura.RESULTS: Crude leptin levels were significantly higher in subjects with migraine than controls (Mann-Whitney U = 515,102, p = 6 × 10(-7)). When performing adjusted analyses, leptin levels were found to be significantly higher in subjects with migraine (odds ratio = 1.22, p = 0.024) and migraine with aura (odds ratio = 1.34, p = 0.004).CONCLUSION: High leptin levels might play a role in the pathogenesis of migraine and migraine with aura.
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Preisig, MartinDepartment of Psychiatry, Lausanne University Hospital, Prilly, Switzerland.
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Castelao, EnriqueDepartment of Psychiatry, Lausanne University Hospital, Prilly, Switzerland.
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Glaus, JenniferGenetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA.
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Cunningham, Janet L.Uppsala universitet,Psykiatri, Akademiska sjukhuset(Swepub:uu)janecunn
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Del Zompo, MariaDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
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Merikangas, Kathleen R.Genetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA.
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Schiöth, Helgi B.Uppsala universitet,Funktionell farmakologi(Swepub:uu)helgschi
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Mwinyi, JessicaUppsala universitet,Funktionell farmakologi(Swepub:uu)jesmw847
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Uppsala universitetFunktionell farmakologi
(creator_code:org_t)
Related titles
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In:Cephalalgia: SAGE Publications37:5, s. 435-4410333-10241468-2982
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