Sökning: WFRF:(Brooks Samantha J.) >
Early-life adversit...
Early-life adversity and orbitofrontal and cerebellar volumes in adults with obsessive-compulsive disorder : voxel-based morphometry study.
-
- Brooks, Samantha J (författare)
- Uppsala universitet,Funktionell farmakologi
-
Naidoo, Vanesh (författare)
-
Roos, Annerine (författare)
-
visa fler...
-
Fouché, Jean-Paul (författare)
-
Lochner, Christine (författare)
-
Stein, Dan J (författare)
-
visa färre...
-
(creator_code:org_t)
- 2018-01-02
- 2016
- Engelska.
-
Ingår i: British Journal of Psychiatry. - : Royal College of Psychiatrists. - 0007-1250 .- 1472-1465. ; 208:1, s. 34-41
- Relaterad länk:
-
https://www.cambridg...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND: Early-life adversity is a risk for obsessive-compulsive disorder (OCD), but the impact at the neural level is less clear.AIMS: To investigate the association between brain volumes and early-life adversity in individuals with a diagnosis of OCD only.METHOD: The Childhood Trauma Questionnaire (CTQ-28) was used to assess early-life adversity in 21 participants with OCD and 25 matched healthy controls. The relationship between global and regional brain volume and early-life adversity was measured using voxel-based morphometry (VBM). All data were corrected for multiple comparisons using family-wise error (FWE) at P<0.05.RESULTS: In the OCD group, correlations with total CTQ scores were positively associated with a larger right orbitofrontal cortex volume. Physical neglect was higher in the OCD group than in controls and was positively associated with larger right cerebellum volume in the OCD group only.CONCLUSIONS: Larger brain volumes may reflect underlying developmental neuropathology in adults with OCD who also have experience of childhood trauma.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas