Genetic variants associated with angiotensin-converting enzyme inhibitor-induced cough: a genome-wide association study in a Swedish population

Hallberg, PärUppsala universitet,Klinisk farmakogenomik och osteoporos,Science for Life Laboratory, SciLifeLab (author)

Genetic variants associated with angiotensin-converting enzyme inhibitor-induced cough : a genome-wide association study in a Swedish population

Aim: We conducted a genome-wide association study on angiotensin-converting enzyme inhibitor-induced cough and used our dataset to replicate candidate genes iden-tified in previous studies. Patients & methods: A total of 124 patients and 1345 treated controls were genotyped using Illumina arrays. The genome-wide significance level was set to p < 5 x 10(-8). Results: We identified nearly genome-wide significant associations in CLASP1, PDE11A, KCNMB2, TGFA, SLC38A6 and MMP16. The strongest association was with rs62151109 in CLASP1 (odds ratio: 3.97; p = 9.44 x 10(-8)). All top hits except two were located in intronic or noncoding DNA regions. None of the candidate genes were significantly associated in our study. Conclusion: Angiotensin-converting enzyme inhibitor-induced cough is potentially associated with genes that are independent of bradykinin pathways.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmakologi och toxikologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmacology and Toxicology hsv//eng
angiotensin converting enzyme inhibitors
bradykinin
cough
drug-related side effects and adverse reactions
enalapril
genome-wide association study
lisinopril
pharmacogenetics
quinapril
ramipril

Persson, MatildaUppsala universitet,Klinisk farmakogenomik och osteoporos,Science for Life Laboratory, SciLifeLab(Swepub:uu)matpe274 (author)
Axelsson, TomasUppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab(Swepub:uu)toaxe957 (author)
Cavalli, MarcoUppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab(Swepub:uu)marca978 (author)
Norling, PiaSickla Hlth Ctr, Nacka, Sweden. (author)
Johansson, Hans-ErikUppsala universitet,Geriatrik(Swepub:uu)hanjo402 (author)
Yue, Qun-YingMed Prod Agcy, Uppsala, Sweden. (author)
Magnusson, Patrik K. E.Karolinska Institutet (author)
Wadelius, ClaesUppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab(Swepub:uu)claeswad (author)
Eriksson, NiclasUppsala universitet,Uppsala kliniska forskningscentrum (UCR),Klinisk farmakogenomik och osteoporos(Swepub:uu)nieri103 (author)
Wadelius, MiaUppsala universitet,Klinisk farmakogenomik och osteoporos,Science for Life Laboratory, SciLifeLab(Swepub:uu)miawadel (author)
Uppsala universitetKlinisk farmakogenomik och osteoporos (creator_code:org_t)

In:Pharmacogenomics (London): FUTURE MEDICINE LTD18:3, s. 201-2131462-24161744-8042

By the author/editor: Hallberg, Pär; Persson, Matilda; Axelsson, Tomas; Cavalli, Marco; Norling, Pia; Johansson, Hans- ...; show more...; Yue, Qun-Ying; Magnusson, Patri ...; Wadelius, Claes; Eriksson, Niclas; Wadelius, Mia; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Pharmacology and ...

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