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Prevalence and influence of cys407* Grm2 mutation in Hannover-derived Wistar rats : mGlu2 receptor loss links to alcohol intake, risk taking and emotional behaviour.

Wood, Christian M. (författare)
School of Physiology, Pharmacology and Neuroscience, University of Bristol.
Nicolas, Celine S. (författare)
School of Physiology, Pharmacology and Neuroscience, University of Bristol
Choi, Sun-Lim (författare)
School of Physiology, Pharmacology and Neuroscience, University of Bristol
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Roman, Erika (författare)
Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Neuropharmacology, Addiction and Behavior
Nylander, Ingrid, 1957- (författare)
Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Neuropharmacology, Addiction and Behavior
Fernandez-Teruel, Alberto (författare)
Department of Psychiatry and Forensic Medicine, Institute of Neurosciences, Autonomous University of Barcelona
Kiianmaa, Kalervo (författare)
Department of Alcohol, Drugs and Addiction, National Institute for Health and Welfare, POB 30 00271 Helsinki
Bienkowski, Przemyslaw (författare)
Department of Pharmacology, Institute of Psychiatry and Neurology, Warsaw.
de Jong, Trynke R. (författare)
Department of Behavioural and Molecular Neuroendocrinology, University of Regensburg
Colombo, Giancarlo (författare)
Neuroscience Institute, Section of Cagliari, National Research Council of Italy
Chastagnier, Denis (författare)
Janvier Labs, CS4105 Le Genest-Saint-Isle
Wafford, Keith A (författare)
Eli Lilly Research Laboratories, Windlesham
Collingridge, Graham L. (författare)
School of Physiology, Pharmacology and Neuroscience, University of Bristol
Wildt, Sheryl J (författare)
Envigo, 8520 Allison Pointe Boulevard, Indianapolis IN 46250
Conway-Campbell, Becky L (författare)
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building
Robinson, Emma S.J. (författare)
School of Physiology, Pharmacology and Neuroscience, University of Bristol
Lodge, David (författare)
School of Physiology, Pharmacology and Neuroscience, University of Bristol
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School of Physiology, Pharmacology and Neuroscience, University of Bristol School of Physiology, Pharmacology and Neuroscience, University of Bristol (creator_code:org_t)
Elsevier BV, 2017
2017
Engelska.
Ingår i: Neuropharmacology. - : Elsevier BV. - 0028-3908 .- 1873-7064. ; 115, s. 128-138
  • Forskningsöversikt (refereegranskat)
Abstract Ämnesord
Stäng  
  • Modulation of metabotropic glutamate 2 (mGlu2) receptor function has huge potential for treating psychiatric and neurological diseases. Development of drugs acting on mGlu2 receptors depends on the development and use of translatable animal models of disease. We report here a stop codon mutation at cysteine 407 in Grm2 (cys407*) that is common in some Wistar rats. Therefore, researchers in this field need to be aware of strains with this mutation. Our genotypic survey found widespread prevalence of the mutation in commercial Wistar strains, particularly those known as Han Wistar. Such Han Wistar rats are ideal for research into the separate roles of mGlu2 and mGlu3 receptors in CNS function. Previous investigations, unknowingly using such mGlu2 receptor-lacking rats, provide insights into the role of mGlu2 receptors in behaviour. The Grm2 mutant rats, which dominate some selectively bred lines, display characteristics of altered emotionality, impulsivity and risk-related behaviours and increased voluntary alcohol intake compared with their mGlu2 receptor-competent counterparts. In addition, the data further emphasize the potential therapeutic role of mGlu2 receptors in psychiatric and neurological disease, and indicate novel methods of studying the role of mGlu2 and mGlu3 receptors.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)

Nyckelord

Metabotropic glutamate receptor; mGlu2; Grm2 mutation; Wistar rats; Han Wistar rats; Emotionality; Anxiety; Selectively bred rats; Alcohol preference

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