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Potent P2Y(12) Inhi...
Potent P2Y(12) Inhibitors in Men Versus Women : A Collaborative Meta-Analysis of Randomized Trials
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- Lau, Emily S. (författare)
- Brigham & Womens Hosp, Dept Med, 75 Francis St, Boston, MA 02115 USA.
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- Braunwald, Eugene (författare)
- Brigham & Womens Hosp, Div Cardiovasc, TIMI Study Grp, 60 Fenwood Rd,7th Floor, Boston, MA 02115 USA.
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- Murphy, Sabina A. (författare)
- Brigham & Womens Hosp, Div Cardiovasc, TIMI Study Grp, 60 Fenwood Rd,7th Floor, Boston, MA 02115 USA.
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- Wiviott, Stephen D. (författare)
- Brigham & Womens Hosp, Div Cardiovasc, TIMI Study Grp, 60 Fenwood Rd,7th Floor, Boston, MA 02115 USA.
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- Bonaca, Marc P. (författare)
- Brigham & Womens Hosp, Div Cardiovasc, TIMI Study Grp, 60 Fenwood Rd,7th Floor, Boston, MA 02115 USA.
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- Husted, Steen (författare)
- Arhus Univ Hosp, Dept Cardiol, Aarhus, Denmark.
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- James, Stefan K (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Wallentin, Lars (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Clemmensen, Peter (författare)
- Univ Heart Ctr Hamburg Eppendorf, Dept Gen & Intervent Cardiol, Hamburg, Germany.;Univ Southern Denmark, Nykoebing Hosp F, Dept Med, Odense, Denmark.
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- Roe, Matthew T. (författare)
- Duke Clin Res Inst, Div Cardiol, Durham, NC USA.
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- Ohman, E. Magnus (författare)
- Duke Clin Res Inst, Div Cardiol, Durham, NC USA.
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- Harrington, Robert A. (författare)
- Stanford Univ, Dept Med, Stanford, CA 94305 USA.
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- Mega, Jessica L. (författare)
- Verily Life Sci, Mountain View, CA USA.
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- Bhatt, Deepak L. (författare)
- Brigham & Womens Hosp, Div Cardiovasc, TIMI Study Grp, 60 Fenwood Rd,7th Floor, Boston, MA 02115 USA.
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- Sabatine, Marc S. (författare)
- Brigham & Womens Hosp, Div Cardiovasc, TIMI Study Grp, 60 Fenwood Rd,7th Floor, Boston, MA 02115 USA.
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- O'Donoghue, Michelle L. (författare)
- Brigham & Womens Hosp, Div Cardiovasc, TIMI Study Grp, 60 Fenwood Rd,7th Floor, Boston, MA 02115 USA.
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Brigham & Womens Hosp, Dept Med, 75 Francis St, Boston, MA 02115 USA Brigham & Womens Hosp, Div Cardiovasc, TIMI Study Grp, 60 Fenwood Rd,7th Floor, Boston, MA 02115 USA. (creator_code:org_t)
- Elsevier BV, 2017
- 2017
- Engelska.
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Ingår i: Journal of the American College of Cardiology. - : Elsevier BV. - 0735-1097 .- 1558-3597. ; 69:12, s. 1549-1559
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- BACKGROUND: Sex-specific differences in response to antiplatelet therapies have been described. Whether women and men derive comparable benefit from intensification of antiplatelet therapy remains uncertain.OBJECTIVES: The study investigated the efficacy and safety of the potent P2Y(12) inhibitors in patients with coronary artery disease.METHODS: A collaborative sex-specific meta-analysis was conducted of phase III or IV randomized trials of potent P2Y(12) inhibitors, including prasugrel, ticagrelor, and intravenous cangrelor. Seven trials were included that enrolled a total of 24,494 women and 63,346 men. Major adverse cardiovascular events (MACE) were defined as the primary endpoint for each trial.RESULTS: Potent P2Y(12) inhibitors significantly reduced the risk of MACE by 14% in women (hazard ratio [HR]: 0.86; 95% confidence interval [CI]: 0.78 to 0.94) and by 15% in men (HR: 0.85; 95% CI: 0.80 to 0.90; p interaction = 0.93). Treatment reduced the risk of myocardial infarction by 13% in women (HR: 0.87; 95% CI: 0.78 to 0.96) and 16% in men (HR: 0.84; 95% CI: 0.77 to 0.91; p interaction = 0.65), and the risk of stent thrombosis by 51% in women (HR: 0.49; 95% CI: 0.37 to 0.65) and 41% in men (HR: 0.59; 95% CI: 0.42 to 0.84; p interaction = 0.85). Directional consistency was seen for cardiovascular death in women (HR: 0.87; 95% CI: 0.76 to 1.01) and men (HR: 0.85; 95% CI: 0.77 to 0.95; p interaction = 0.86). The potent P2Y(12) inhibitors increased major bleeding in women (HR: 1.28; 95% CI: 0.87 to 1.88) and men (HR: 1.52; 95% CI: 1.12 to 2.07; p interaction = 0.62).CONCLUSIONS: In randomized trials, the efficacy and safety of the potent P2Y(12) inhibitors were comparable between men and women. Given these data, sex should not influence patient selection for the administration of potent P2Y(12) inhibitors.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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Lau, Emily S.
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Braunwald, Eugen ...
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Murphy, Sabina A ...
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Wiviott, Stephen ...
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Bonaca, Marc P.
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Husted, Steen
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James, Stefan K
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Wallentin, Lars
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Clemmensen, Pete ...
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Roe, Matthew T.
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Ohman, E. Magnus
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Harrington, Robe ...
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Mega, Jessica L.
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Bhatt, Deepak L.
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Sabatine, Marc S ...
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O'Donoghue, Mich ...
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