Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease

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Webb, Thomas R.Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Glenfield Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England.,University of Leicester,Glenfield Hospital (författare)

Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease

Artikel/kapitelEngelska2017

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Elsevier BV,2017
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LIBRIS-ID:oai:DiVA.org:uu-318961
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-318961URI
https://doi.org/10.1016/j.jacc.2016.11.056DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-132800URI
https://lup.lub.lu.se/record/ffd68d88-5a74-4c0d-aa04-94d31fdc9d79URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:135266846URI

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BACKGROUND Genome-wide association studies have so far identified 56 loci associated with risk of coronary artery disease (CAD). Many CAD loci show pleiotropy; that is, they are also associated with other diseases or traits.OBJECTIVES This study sought to systematically test if genetic variants identified for non-CAD diseases/traits also associate with CAD and to undertake a comprehensive analysis of the extent of pleiotropy of all CAD loci.METHODS In discovery analyses involving 42,335 CAD cases and 78,240 control subjects we tested the association of 29,383 common (minor allele frequency >5%) single nucleotide polymorphisms available on the exome array, which included a substantial proportion of known or suspected single nucleotide polymorphisms associated with common diseases or traits as of 2011. Suggestive association signals were replicated in an additional 30,533 cases and 42,530 control subjects. To evaluate pleiotropy, we tested CAD loci for association with cardiovascular risk factors (lipid traits, blood pressure phenotypes, body mass index, diabetes, and smoking behavior), as well as with other diseases/traits through interrogation of currently available genome-wide association study catalogs.RESULTS We identified 6 new loci associated with CAD at genome-wide significance: on 2q37 (KCNJ13-GIGYF2), 6p21 (C2), 11p15 (MRVI1-CTR9), 12q13 (LRP1), 12q24 (SCARB1), and 16q13 (CETP). Risk allele frequencies ranged from 0.15 to 0.86, and odds ratio per copy of the risk allele ranged from 1.04 to 1.09. Of 62 new and known CAD loci, 24 (38.7%) showed statistical association with a traditional cardiovascular risk factor, with some showing multiple associations, and 29 (47%) showed associations at p < 1 x 10(-4) with a range of other diseases/traits.CONCLUSIONS We identified 6 loci associated with CAD at genome-wide significance. Several CAD loci show substantial pleiotropy, which may help us understand the mechanisms by which these loci affect CAD risk.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
cholesteryl ester transfer protein
expression quantitative trait loci
genetics
genome-wide association
single nucleotide polymorphism
cholesteryl ester transfer protein
expression quantitative trait loci
genetics
genome-wide association
single nucleotide polymorphism

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Erdmann, JeanetteUniv Lubeck, Inst Cardiogenet, Lubeck, Germany.;DZHK German Res Ctr Cardiovasc Res, Lubeck, Germany.;Univ Heart Ctr Luebeck, Lubeck, Germany.,University of Lübeck,German Centre for Cardiovascular Research (författare)
Stirrups, Kathleen E.Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;Univ Cambridge, Dept Haematol, Cambridge, England.,University of Cambridge,Queen Mary University (författare)
Stitziel, Nathan O.Washington Univ, Sch Med, Dept Med, Div Cardiovasc, St Louis, MO 63110 USA.;Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA.;Washington Univ, Sch Med, McDonnell Genome Inst, St Louis, MO USA.,Washington University in St. Louis,University of Verona (författare)
Masca, Nicholas G. D.Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Glenfield Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England.,Glenfield Hospital,University of Leicester,University of Verona (författare)
Jansen, HenningTech Univ Munich, Deutsch Herzzentrum Munchen, Munich, Germany.;DZHK, Munich, Germany.,German Centre for Cardiovascular Research,Technical University of Munich (författare)
Kanoni, StavroulaQueen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.,Queen Mary University (författare)
Nelson, Christopher P.Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Glenfield Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England.,Glenfield Hospital,University of Leicester (författare)
Ferrario, Paola G.DZHK German Res Ctr Cardiovasc Res, Lubeck, Germany.;Univ Lubeck, Inst Med Biometrie & Stat, Lubeck, Germany.,German Centre for Cardiovascular Research,University of Lübeck (författare)
Koenig, Inke R.DZHK German Res Ctr Cardiovasc Res, Lubeck, Germany.;Univ Lubeck, Inst Med Biometrie & Stat, Lubeck, Germany.,German Centre for Cardiovascular Research,University of Lübeck (författare)
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Hamby, Stephen E.Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Glenfield Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England.,Glenfield Hospital,University of Leicester (författare)
Betsholtz, ChristerKarolinska Institutet,Uppsala University,Karolinska Institute,Uppsala universitet,Vaskulärbiologi,Karolinska Inst, Vasc Biol Unit, Dept Med Biochem & Biophys, Stockholm, Sweden.(Swepub:uu)chbet517 (författare)
Ruusalepp, ArnoUniv Tartu, Inst Biomed & Translat Med, Dept Physiol, Tartu, Estonia.;Tartu Univ Hosp, Dept Cardiac Surg, Tartu, Estonia.;Clin Gene Networks AB, Stockholm, Sweden.,University of Tartu,Tartu University Hospital,Clinical Gene Networks AB (författare)
Franzen, OscarClin Gene Networks AB, Stockholm, Sweden.;Icahn Sch Med Mt Sinai, Inst Genom & Multiscale Biol, Dept Genet & Genom Sci, New York, NY 10029 USA.,Icahn School of Medicine at Mount Sinai,Clinical Gene Networks AB (författare)
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Bjoerkegren, Johan L. M.Karolinska Institutet,Karolinska Institute,University of Tartu,Clinical Gene Networks AB,Icahn School of Medicine at Mount Sinai (författare)
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Dube, Marie-PierreUniv Montreal, Fac Med, Dept Med, Montreal, PQ, Canada.;Montreal Heart Inst, Montreal, PQ, Canada.,Montreal Heart Institute,University Of Quebec In Montreal (författare)
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Farrall, MartinUniv Oxford, Radcliffe Dept Med, Div Cardiovasc Med, Oxford, England.;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.,University of Oxford,Wellcome Trust Centre for Human Genetics (författare)
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Do, RonIcahn Sch Med Mt Sinai, Genet Obes & Related Metab Traits Program, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Ctr Stat Genet, Dept Genet & Genom Sci, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, Icahn Inst Genom & Multiscale Biol, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Zena & Michael Weiner Cardiovasc Inst, New York, NY 10029 USA.,Icahn School of Medicine at Mount Sinai (författare)
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Hengstenberg, ChristianWashington Univ, Sch Med, McDonnell Genome Inst, St Louis, MO USA.;Tech Univ Munich, Deutsch Herzzentrum Munchen, Munich, Germany.,Technical University of Munich,Washington University in St. Louis (författare)
Hoffmann, PerUniv Bonn, Inst Human Genet, Bonn, Germany.;Univ Bonn, Dept Genom, Life & Brain Ctr, Bonn, Germany.;Univ Basel, Dept Biomed, Div Med Genet, Basel, Switzerland.,University of Basel,University of Bonn (författare)
Holmen, Oddgeir L.Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, HUNT Res Ctr, Levanger, Norway.;Trondheim Reg & Univ Hosp, St Olav Hosp, Trondheim, Norway.,St. Olav’s University Hospital,Norwegian University of Science and Technology (författare)
Hveem, KristianNorwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, HUNT Res Ctr, Levanger, Norway.;Nord Trondelag Hlth Trust, Levanger Hosp, Dept Med, Levanger, Norway.,Norwegian University of Science and Technology (författare)
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Joeckel, Karl-HeinzUniv Hosp Essen, Inst Med Informat Biometry & Epidemiol, Essen, Germany.,University Hospital Essen (författare)
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Laugwitz, Karl L.DZHK, Munich, Germany.;Tech Univ Munich, Klinikum Rechts Isar, Inst Med Klin & Poliklin, Munich, Germany.,German Centre for Cardiovascular Research (författare)
Marouli, EiriniQueen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.,Queen Mary University (författare)
Martinelli, NicolaUniv Verona, Sect Internal Med, Dept Med, Verona, Italy.,University of Verona (författare)
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Mihailov, EvelinUniv Tartu, Estonian Genome Ctr, Tartu, Estonia.,University of Tartu (författare)
Escher, Stefan A.Lund Univ, Dept Clin Sci, Ctr Diabet, Genet & Mol Epidemiol Unit, Malmo, Sweden.,Lund University (författare)
Alver, MarisUniv Tartu, Estonian Genome Ctr, Tartu, Estonia.;Inst Mol & Cell Biol, Tartu, Estonia.,University of Tartu (författare)
Moebus, SusanneUniv Hosp Essen, Inst Med Informat Biometry & Epidemiol, Essen, Germany.,University Hospital Essen (författare)
Morris, Andrew D.Univ Edinburgh, Sch Med, Sch Mol Genet & Populat Hlth Sci, Teviot Pl, Edinburgh, Midlothian, Scotland.,University of Edinburgh (författare)
Varga, Tibor V.Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)med-tv_ (författare)
Nikpay, MajidUniv Ottawa, Inst Heart, Ruddy Canadian Cardiovasc Genet Ctr, Ottawa, ON, Canada.,University of Ottawa (författare)
Olivieri, OlivieroUniv Verona, Sect Internal Med, Dept Med, Verona, Italy.,Merck Sharp And Dohme Corp., US (författare)
Provost, SylvieMontreal Heart Inst, Montreal, PQ, Canada.,Montreal Heart Institute (författare)
AlQarawi, AlaaKing Abdulaziz Univ, Princess Al Jawhara Al Brahim Ctr Excellence R, Jeddah, Saudi Arabia.,Icahn School of Medicine at Mount Sinai,University of Dundee (författare)
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Akinsansya, Karen O.Merck Sharp & Dohme Ltd, Rahway, NJ USA. (författare)
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Yin, WuMerck Sharp & Dohme Ltd, Rahway, NJ USA.,Merck Sharp And Dohme Corp., US (författare)
Asselbergs, Folkert W.UMC Utrecht, Div Heart & Lungs, Dept Cardiol, Utrecht, Netherlands.;ICIN Netherlands Heart Inst, Durrer Ctr Cardiogenet Res, Utrecht, Netherlands.;UCL, Fac Populat Hlth Sci, Inst Cardiovasc Sci, London, England.,Interuniversity Cardiology Institute of the Netherlands,University College London,University Medical Center Utrecht (författare)
Kooperberg, CharlesFred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA.,Fred Hutchinson Cancer Research Center (författare)
Jackson, Rebecca D.Ohio State Univ, Dept Med, Div Endocrinol Diabet & Metab, Columbus, OH 43210 USA.,Ohio State University (författare)
Stahl, EliIcahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA. (författare)
Mueller-Nurasyid, MartinaDZHK, Munich, Germany.;Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, Neuherberg, Germany.;Ludwig Maximilians Univ Munchen, Dept Med 1, Univ Hosp Grosshadern, Munich, Germany.,University Hospital Munich,German Centre for Cardiovascular Research (författare)
Strauch, KonstantinHelmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, Neuherberg, Germany.;Ludwig Maximilians Univ Munchen, Chair Genet Epidemiol, Inst Med Informat Biometry & Epidemiol, Munich, Germany.,Ludwig-Maximilian University of Munich (författare)
Varga, Tibor V.Lund Univ, Dept Clin Sci, Ctr Diabet, Genet & Mol Epidemiol Unit, Malmo, Sweden. (författare)
Waldenberger, MelanieHelmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Res Unit Mol Epidemiol, Neuherberg, Germany.;Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 2, Neuherberg, Germany. (författare)
Zeng, LingyaoTech Univ Munich, Deutsch Herzzentrum Munchen, Munich, Germany.;DZHK, Munich, Germany.,German Centre for Cardiovascular Research,Technical University of Munich (författare)
Chowdhury, RajivUniv Cambridge, Dept Publ Hlth & Primary Care, MRC BHF Cardiovasc Epidemiol Unit, Cambridge, England.,University of Cambridge (författare)
Salomaa, VeikkoNatl Inst Hlth & Welf THL, Helsinki, Finland.,Finnish National Institute for Health and Welfare (författare)
Ford, IanUniv Glasgow, Robertson Ctr Biostat, Glasgow, Lanark, Scotland.,University of Glasgow (författare)
Jukema, J. WouterLeiden Univ, Med Ctr, Leiden & Interuniv Cardiol Inst Netherlands, Dept Cardiol, Utrecht, Netherlands.,Leiden University Medical Centre (författare)
Amouyel, PhilippeUniv Lille, INSERM, CHU Lille, Inst Pasteur Lille,RID AGE U1167, Lille, France.,University of Lille (författare)
Kontto, JukkaFinnish National Institute for Health and Welfare (författare)
Nordestgaard, Borge G.Copenhagen Univ Hosp & Med Sci, Copenhagen, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark.,Copenhagen University Hospital (författare)
Ferrieres, JeanToulouse Univ, Sch Med, Toulouse, France.,University of Toulouse,Icahn School of Medicine at Mount Sinai (författare)
Saleheen, DanishUniv Penn, Perelman Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA.;Ctr Noncommunicable Dis, Karachi, Pakistan.,University of Pennsylvania,Center for Non-Communicable Diseases (författare)
Sattar, NaveedUniv Glasgow, Glasgow Cardiovasc Res Ctr, British Heart Fdn, Glasgow, Lanark, Scotland.,University of Glasgow (författare)
Surendran, PraveenLudwig Maximilians Univ Munchen, Chair Genet Epidemiol, Inst Med Informat Biometry & Epidemiol, Munich, Germany.,Ludwig-Maximilian University of Munich (författare)
Wagner, AlineUniv Strasbourg, Dept Epidemiol & Publ Hlth, Strasbourg, France.,University of Strasbourg (författare)
Young, RobinUniv Cambridge, Dept Publ Hlth & Primary Care, MRC BHF Cardiovasc Epidemiol Unit, Cambridge, England.,University of Cambridge (författare)
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Butterworth, Adam S.Univ Cambridge, Dept Publ Hlth & Primary Care, MRC BHF Cardiovasc Epidemiol Unit, Cambridge, England.;Univ Cambridge, Res Unit Donor Hlth & Genom, Natl Inst Hlth Res Blood & Transplant, Cambridge, England.,University of Cambridge (författare)
Danesh, JohnUniv Cambridge, Dept Publ Hlth & Primary Care, MRC BHF Cardiovasc Epidemiol Unit, Cambridge, England.;Univ Cambridge, Res Unit Donor Hlth & Genom, Natl Inst Hlth Res Blood & Transplant, Cambridge, England.;Wellcome Trust Sanger Inst, Cambridge, England. (författare)
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Franks, Paul W.Lund University,Lunds universitet,Umeå universitet,Avdelningen för medicin,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Norrland University Hospital,Harvard University(Swepub:lu)med-plf (författare)
Girelli, DomenicoUniv Verona, Sect Internal Med, Dept Med, Verona, Italy. (författare)
Hall, Alistair S.Univ Leeds, Leeds Inst Genet Hlth & Therapeut, Leeds, W Yorkshire, England.,University of Leeds (författare)
Hovingh, G. KeesAcad Med Ctr, Dept Vasc Med, Amsterdam, Netherlands.,Academic Medical Center of University of Amsterdam (AMC) (författare)
Kastrati, AdnanTech Univ Munich, Deutsch Herzzentrum Munchen, Munich, Germany.,Technical University of Munich (författare)
Lieb, WolfgangChristian Albrechts Univ Kiel, Inst Epidemiol & Biobank Popgen, Kiel, Germany.,University of Kiel (författare)
Meitinger, ThomasDZHK, Munich, Germany.;Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Human Genet, Neuherberg, Germany.;Tech Univ Munich, Inst Human Genet, Munich, Germany.,Technical University of Munich,German Centre for Cardiovascular Research (författare)
Kraus, William E.Duke Univ, Duke Mol Physiol Inst, Durham, NC USA.;Duke Univ, Dept Med, Div Cardiol, Durham, NC USA.,Duke University (författare)
Shah, Svati H.Duke Univ, Duke Mol Physiol Inst, Durham, NC USA.;Duke Univ, Dept Med, Div Cardiol, Durham, NC USA.,Duke University (författare)
McPherson, RuthUniv Ottawa, Inst Heart, Ruddy Canadian Cardiovasc Genet Ctr, Ottawa, ON, Canada.,University of Ottawa (författare)
Orho-Melander, MarjuLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)endo-mor (författare)
Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome (författare)
Metspalu, AndresUniv Tartu, Estonian Genome Ctr, Tartu, Estonia.;Inst Mol & Cell Biol, Tartu, Estonia.,University of Tartu (författare)
Palmer, Colin N. A.Univ Dundee, Hosp & Med Sch, Med Res Inst, Dundee, Scotland. (författare)
Peters, AnnetteDZHK, Munich, Germany.;Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 2, Neuherberg, Germany.,German Centre for Cardiovascular Research (författare)
Rader, Daniel J.Univ Penn, Dept Genet, Cardiovasc Inst, Philadelphia, PA 19104 USA.;Univ Penn, Inst Translat Med & Therapeut, Perelman Sch Med, Philadelphia, PA 19104 USA.,University of Pennsylvania (författare)
Reilly, Muredach P.Columbia Univ, Dept Med, Div Cardiol, New York, NY USA.;Columbia Univ, Irving Inst Clin & Translat Res, New York, NY USA.,Columbia University (författare)
Loos, Ruth J. F.Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Genet Obes & Related Metab Traits Program, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA. (författare)
Reiner, Alex P.Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA.;Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.,University of Washington,Fred Hutchinson Cancer Research Center (författare)
Roden, Dan M.Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN USA.;Vanderbilt Univ, Med Ctr, Dept Pharmacol, Nashville, TN 37232 USA.,Vanderbilt University (författare)
Tardif, Jean-ClaudeUniv Montreal, Fac Med, Dept Med, Montreal, PQ, Canada.;Montreal Heart Inst, Montreal, PQ, Canada.,Montreal Heart Institute,University Of Quebec In Montreal (författare)
Thompson, John R.Glenfield Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England.;Univ Leicester, Dept Hlth Sci, Leicester, Leics, England.,Glenfield Hospital,University of Leicester (författare)
Wareham, Nicholas J.Addenbrookes Hosp, MRC Epidemiol Unit, Inst Metab Sci, Cambridge, England.,Addenbrooke's Hospital (författare)
Watkins, HughUniv Oxford, Radcliffe Dept Med, Div Cardiovasc Med, Oxford, England.;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.,Wellcome Trust Centre for Human Genetics,University of Oxford (författare)
Willer, Cristen J.Univ Montreal, Fac Med, Dept Med, Montreal, PQ, Canada.;Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA.;Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA.,University of Michigan,University Of Quebec In Montreal (författare)
Samani, Nilesh J.Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Glenfield Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England.,University of Leicester,Glenfield Hospital (författare)
Schunkert, HeribertTech Univ Munich, Deutsch Herzzentrum Munchen, Munich, Germany.;DZHK, Munich, Germany.,German Centre for Cardiovascular Research,Technical University of Munich (författare)
Deloukas, PanosQueen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;King Abdulaziz Univ, Princess Al Jawhara Al Brahim Ctr Excellence R, Jeddah, Saudi Arabia.,Queen Mary University,King Abdulaziz University (författare)
Kathiresan, SekarMassachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA.;Harvard Med Sch, Dept Med, Boston, MA USA.;Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA.,Broad Institute,Harvard Medical School,Massachusetts General Hospital (författare)
Virtamo, J (författare)
Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Glenfield Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England.University of Leicester (creator_code:org_t)

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Ingår i:Journal of the American College of Cardiology: Elsevier BV69:7, s. 823-8360735-10971558-3597

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