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  • Hansson, Nils Henrik (author)

Evaluation of ECG-gated [(11)C]acetate PET for measuring left ventricular volumes, mass, and myocardial external efficiency

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2016-04-19
  • Springer Science and Business Media LLC,2016
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-319488
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-319488URI
  • https://doi.org/10.1007/s12350-015-0331-0DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND: Noninvasive estimation of myocardial external efficiency (MEE) requires measurements of left ventricular (LV) oxygen consumption with [(11)C]acetate PET in addition to LV stroke volume and mass with cardiovascular magnetic resonance (CMR). Measuring LV geometry directly from ECG-gated [(11)C]acetate PET might enable MEE evaluation from a single PET scan. Therefore, we sought to establish the accuracy of measuring LV volumes, mass, and MEE directly from ECG-gated [(11)C]acetate PET.METHODS: Thirty-five subjects with aortic valve stenosis underwent ECG-gated [(11)C]acetate PET and CMR. List mode PET data were rebinned into 16-bin ECG-gated uptake images before measuring LV volumes and mass using commercial software and compared to CMR. Dynamic datasets were used for calculation of mean LV oxygen consumption and MEE.RESULTS: LV mass, volumes, and ejection fraction measured by CMR and PET correlated strongly (r = 0.86-0.92, P < .001 for all), but were underestimated by PET (P < .001 for all except ESV P = .79). PET-based MEE, corrected for bias, correlated fairly with PET/CMR-based MEE (r = 0.60, P < .001, bias -3 ± 21%, P = .56). PET-based MEE bias was strongly associated with LV wall thickness.CONCLUSIONS: Although analysis-related improvements in accuracy are recommended, LV geometry estimated from ECG-gated [(11)C]acetate PET correlate excellently with CMR and can indeed be used to evaluate MEE.

Subject headings and genre

  • Myocardial external efficiency
  • PET imaging
  • magnetic resonance imaging
  • metabolism: PET

Added entries (persons, corporate bodies, meetings, titles ...)

  • Tolbod, Lars (author)
  • Harms, Johannes (author)
  • Wiggers, Henrik (author)
  • Kim, Won Yong (author)
  • Hansen, Esben (author)
  • Zaremba, Tomas (author)
  • Frøkiær, Jørgen (author)
  • Jakobsen, Steen (author)
  • Sörensen, JensUppsala universitet,Radiologi(Swepub:uu)jenssore (author)
  • Uppsala universitetRadiologi (creator_code:org_t)

Related titles

  • In:Journal of Nuclear Cardiology: Springer Science and Business Media LLC23:4, s. 670-91071-35811532-6551

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