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Arterial spin label...
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Fällmar, DavidUppsala universitet,Radiologi
(författare)
Arterial spin labeling-based Z-maps have high specificity and positive predictive value for neurodegenerative dementia compared to FDG-PET.
- Artikel/kapitelEngelska2017
Förlag, utgivningsår, omfång ...
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2017-04-03
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Springer Science and Business Media LLC,2017
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-319602
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-319602URI
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https://doi.org/10.1007/s00330-017-4784-1DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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OBJECTIVE: Cerebral perfusion analysis based on arterial spin labeling (ASL) MRI has been proposed as an alternative to FDG-PET in patients with neurodegenerative disease. Z-maps show normal distribution values relating an image to a database of controls. They are routinely used for FDG-PET to demonstrate disease-specific patterns of hypometabolism at the individual level. This study aimed to compare the performance of Z-maps based on ASL to FDG-PET.METHODS: Data were combined from two separate sites, each cohort consisting of patients with Alzheimer's disease (n = 18 + 7), frontotemporal dementia (n = 12 + 8) and controls (n = 9 + 29). Subjects underwent pseudocontinuous ASL and FDG-PET. Z-maps were created for each subject and modality. Four experienced physicians visually assessed the 166 Z-maps in random order, blinded to modality and diagnosis.RESULTS: Discrimination of patients versus controls using ASL-based Z-maps yielded high specificity (84%) and positive predictive value (80%), but significantly lower sensitivity compared to FDG-PET-based Z-maps (53% vs. 96%, p < 0.001). Among true-positive cases, correct diagnoses were made in 76% (ASL) and 84% (FDG-PET) (p = 0.168).CONCLUSION: ASL-based Z-maps can be used for visual assessment of neurodegenerative dementia with high specificity and positive predictive value, but with inferior sensitivity compared to FDG-PET.KEY POINTS: • ASL-based Z-maps yielded high specificity and positive predictive value in neurodegenerative dementia. • ASL-based Z-maps had significantly lower sensitivity compared to FDG-PET-based Z-maps. • FDG-PET might be reserved for ASL-negative cases where clinical suspicion persists. • Findings were similar at two study sites.
Ämnesord och genrebeteckningar
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18F-FDG
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Arterial spin labeling MRI
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Dementia
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Neurodegenerative
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Visual assessment
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Haller, SvenUppsala universitet,Radiologi,Univ Med Ctr Freiburg, Dept Neuroradiol, Freiburg, Germany.; Univ Geneva, Fac Med, Geneva, Switzerland.; Affidea CDRC Ctr Diagnost Radiol Carouge, Carouge, Switzerland.(Swepub:uu)sveha228
(författare)
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Lilja, JohanUppsala universitet,Institutionen för kirurgiska vetenskaper,Hermes Med Solut, Stockholm, Sweden(Swepub:uu)johli248
(författare)
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Danfors, TorstenUppsala universitet,Institutionen för kirurgiska vetenskaper(Swepub:uu)tordan
(författare)
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Kilander, LenaUppsala universitet,Geriatrik(Swepub:uu)lekil226
(författare)
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Tolboom, NellekeVrije Univ Amsterdam, Dept Radiol & Nucl Med, Med Ctr, Neurosci Campus, Amsterdam, Netherlands
(författare)
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Egger, KarlUniv Med Ctr Freiburg, Dept Neuroradiol, Freiburg, Germany
(författare)
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Kellner, EliasUniv Freiburg, Dept Radiol, Med Ctr, Fac Med,Med Phys, Freiburg, Germany
(författare)
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Croon, Philip MVrije Univ Amsterdam, Dept Radiol & Nucl Med, Med Ctr, Neurosci Campus, Amsterdam, Netherlands
(författare)
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Verfaillie, Sander C JVrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Med Ctr, Amsterdam, Netherlands
(författare)
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van Berckel, Bart N MVrije Univ Amsterdam, Dept Radiol & Nucl Med, Med Ctr, Neurosci Campus, Amsterdam, Netherlands
(författare)
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Ossenkoppele, RikVrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Med Ctr, Amsterdam, Netherlands
(författare)
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Barkhof, FrederikVrije Univ Amsterdam, Dept Radiol & Nucl Med, Med Ctr, Neurosci Campus, Amsterdam, Netherlands.; UCL, Inst Neurol & Healthcare Engn, London, England.
(författare)
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Larsson, Elna-MarieUppsala universitet,Radiologi(Swepub:uu)elnla305
(författare)
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Uppsala universitetRadiologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Radiology: Springer Science and Business Media LLC27:10, s. 4237-42460938-79941432-1084
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Fällmar, David
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Haller, Sven
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Lilja, Johan
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Danfors, Torsten
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Kilander, Lena
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Tolboom, Nelleke
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visa fler...
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Egger, Karl
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Kellner, Elias
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Croon, Philip M
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Verfaillie, Sand ...
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van Berckel, Bar ...
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Ossenkoppele, Ri ...
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Barkhof, Frederi ...
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Larsson, Elna-Ma ...
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