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Cerebral Magnesium ...
Cerebral Magnesium Levels in Preeclampsia; A Phosphorus Magnetic Resonance Spectroscopy Study
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- Nelander, Maria (author)
- Uppsala universitet,Obstetrisk forskning
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- Weis, Jan, 1956- (author)
- Uppsala universitet,Radiologi
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- Bergman, Lina (author)
- Uppsala universitet,Centrum för klinisk forskning Dalarna,Obstetrisk forskning
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- Larsson, Anders (author)
- Uppsala universitet,Klinisk kemi
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- Wikström, Anna-Karin, 1965- (author)
- Karolinska Institutet,Uppsala universitet,Obstetrisk forskning,Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Stockholm, Sweden
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- Wikström, Johan, 1964- (author)
- Uppsala universitet,Radiologi
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(creator_code:org_t)
- 2017-02-21
- 2017
- English.
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In: American Journal of Hypertension. - : Oxford University Press (OUP). - 0895-7061 .- 1941-7225. ; 30:7, s. 667-672
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Abstract
Subject headings
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- BACKGROUND: Magnesium sulfate (MgSO4) is used as a prophylaxis for eclamptic seizures. The exact mechanism of action is not fully established. We used phosphorus magnetic resonance spectroscopy (31P-MRS) to investigate if cerebral magnesium (Mg2+) levels differ between women with preeclampsia, normal pregnant, and nonpregnant women.METHODS: This cross-sectional study comprised 28 women with preeclampsia, 30 women with normal pregnancies in corresponding gestational week (range: 23-41 weeks) and 11 nonpregnant healthy controls. All women underwent 31P-MRS from the parieto-occipital region of the brain and were interviewed about cerebral symptoms. Differences between groups were assessed by analysis of variance and Tukey's post-hoc test. Correlations between Mg2+ levels and specific neurological symptoms were estimated with Spearman's rank test.RESULTS: Mean maternal cerebral Mg2+ levels were lower in women with preeclampsia (0.12 mM ± 0.02) compared to normal pregnant controls (0.14 mM ± 0.03) (P = 0.04). Nonpregnant and normal pregnant women did not differ in Mg2+ levels. Among women with preeclampsia, lower Mg2+ levels correlated with presence of visual disturbances (P = 0.04). Plasma levels of Mg2+ did not differ between preeclampsia and normal pregnancy.CONCLUSIONS: Women with preeclampsia have reduced cerebral Mg2+ levels, which could explain the potent antiseizure prophylactic properties of MgSO4. Within the preeclampsia group, women with visual disturbances have lower levels of Mg2+ than those without such symptoms.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- 31P-magnetic resonance spectroscopy
- blood pressure
- eclampsia
- hypertension
- magnesium
- magnetic resonance
- preeclampsia.
Publication and Content Type
- ref (subject category)
- art (subject category)
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