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Search: WFRF:(Wiggins C. J.) > (2015-2019) > A DNA methylation b...

  • Liu, C (author)

A DNA methylation biomarker of alcohol consumption.

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2016-11-15
  • Springer Science and Business Media LLC,2018
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-319698
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-319698URI
  • https://doi.org/10.1038/mp.2016.192DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • De tio första författarna delar på förstaförfattarskapet. De sex sista författarna delar på sistaförfattarskapet.
  • The lack of reliable measures of alcohol intake is a major obstacle to the diagnosis and treatment of alcohol-related diseases. Epigenetic modifications such as DNA methylation may provide novel biomarkers of alcohol use. To examine this possibility, we performed an epigenome-wide association study of methylation of cytosine-phosphate-guanine dinucleotide (CpG) sites in relation to alcohol intake in 13 population-based cohorts (ntotal=13 317; 54% women; mean age across cohorts 42-76 years) using whole blood (9643 European and 2423 African ancestries) or monocyte-derived DNA (588 European, 263 African and 400 Hispanic ancestry) samples. We performed meta-analysis and variable selection in whole-blood samples of people of European ancestry (n=6926) and identified 144 CpGs that provided substantial discrimination (area under the curve=0.90-0.99) for current heavy alcohol intake (⩾42 g per day in men and ⩾28 g per day in women) in four replication cohorts. The ancestry-stratified meta-analysis in whole blood identified 328 (9643 European ancestry samples) and 165 (2423 African ancestry samples) alcohol-related CpGs at Bonferroni-adjusted P<1 × 10(-7). Analysis of the monocyte-derived DNA (n=1251) identified 62 alcohol-related CpGs at P<1 × 10(-7). In whole-blood samples of people of European ancestry, we detected differential methylation in two neurotransmitter receptor genes, the γ-Aminobutyric acid-A receptor delta and γ-aminobutyric acid B receptor subunit 1; their differential methylation was associated with expression levels of a number of genes involved in immune function. In conclusion, we have identified a robust alcohol-related DNA methylation signature and shown the potential utility of DNA methylation as a clinically useful diagnostic test to detect current heavy alcohol consumption.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Marioni, R E (author)
  • Hedman, Åsa KUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)ashed124 (author)
  • Pfeiffer, L (author)
  • Tsai, P-C (author)
  • Reynolds, L M (author)
  • Just, A C (author)
  • Duan, Q (author)
  • Boer, C G (author)
  • Tanaka, T (author)
  • Elks, C E (author)
  • Aslibekyan, S (author)
  • Brody, J A (author)
  • Kühnel, B (author)
  • Herder, C (author)
  • Almli, L M (author)
  • Zhi, D (author)
  • Wang, Y (author)
  • Huan, T (author)
  • Yao, C (author)
  • Mendelson, M M (author)
  • Joehanes, R (author)
  • Liang, L (author)
  • Love, S-A (author)
  • Guan, W (author)
  • Shah, S (author)
  • McRae, A F (author)
  • Kretschmer, A (author)
  • Prokisch, H (author)
  • Strauch, K (author)
  • Peters, A (author)
  • Visscher, P M (author)
  • Wray, N R (author)
  • Guo, X (author)
  • Wiggins, K L (author)
  • Smith, A K (author)
  • Binder, E B (author)
  • Ressler, K J (author)
  • Irvin, M R (author)
  • Absher, D M (author)
  • Hernandez, D (author)
  • Ferrucci, L (author)
  • Bandinelli, S (author)
  • Lohman, K (author)
  • Ding, J (author)
  • Trevisi, L (author)
  • Gustafsson, StefanUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)stegu732 (author)
  • Sandling, Johanna K.Uppsala universitet,Molekylär medicin,Reumatologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)josan062 (author)
  • Stolk, L (author)
  • Uitterlinden, A G (author)
  • Yet, I (author)
  • Castillo-Fernandez, J E (author)
  • Spector, T D (author)
  • Schwartz, J D (author)
  • Vokonas, P (author)
  • Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)larslind (author)
  • Li, Y (author)
  • Fornage, M (author)
  • Arnett, D K (author)
  • Wareham, N J (author)
  • Sotoodehnia, N (author)
  • Ong, K K (author)
  • van Meurs, J B J (author)
  • Conneely, K N (author)
  • Baccarelli, A A (author)
  • Deary, I J (author)
  • Bell, J T (author)
  • North, K E (author)
  • Liu, Y (author)
  • Waldenberger, M (author)
  • London, S J (author)
  • Ingelsson, Erik,1975-Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA(Swepub:uu)ering425 (author)
  • Levy, D (author)
  • Uppsala universitetMolekylär epidemiologi (creator_code:org_t)

Related titles

  • In:Molecular Psychiatry: Springer Science and Business Media LLC23, s. 422-4331359-41841476-5578

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