Search: (WFRF:(Arnett D)) srt2:(2015-2019) >
A DNA methylation b...
A DNA methylation biomarker of alcohol consumption.
-
Liu, C (author)
-
Marioni, R E (author)
-
- Hedman, Åsa K (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
-
show more...
-
Pfeiffer, L (author)
-
Tsai, P-C (author)
-
Reynolds, L M (author)
-
Just, A C (author)
-
Duan, Q (author)
-
Boer, C G (author)
-
Tanaka, T (author)
-
Elks, C E (author)
-
Aslibekyan, S (author)
-
Brody, J A (author)
-
Kühnel, B (author)
-
Herder, C (author)
-
Almli, L M (author)
-
Zhi, D (author)
-
Wang, Y (author)
-
Huan, T (author)
-
Yao, C (author)
-
Mendelson, M M (author)
-
Joehanes, R (author)
-
Liang, L (author)
-
Love, S-A (author)
-
Guan, W (author)
-
Shah, S (author)
-
McRae, A F (author)
-
Kretschmer, A (author)
-
Prokisch, H (author)
-
Strauch, K (author)
-
Peters, A (author)
-
Visscher, P M (author)
-
Wray, N R (author)
-
Guo, X (author)
-
Wiggins, K L (author)
-
Smith, A K (author)
-
Binder, E B (author)
-
Ressler, K J (author)
-
Irvin, M R (author)
-
Absher, D M (author)
-
Hernandez, D (author)
-
Ferrucci, L (author)
-
Bandinelli, S (author)
-
Lohman, K (author)
-
Ding, J (author)
-
Trevisi, L (author)
-
- Gustafsson, Stefan (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
-
- Sandling, Johanna K. (author)
- Uppsala universitet,Molekylär medicin,Reumatologi,Science for Life Laboratory, SciLifeLab
-
Stolk, L (author)
-
Uitterlinden, A G (author)
-
Yet, I (author)
-
Castillo-Fernandez, J E (author)
-
Spector, T D (author)
-
Schwartz, J D (author)
-
Vokonas, P (author)
-
- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi
-
Li, Y (author)
-
Fornage, M (author)
-
Arnett, D K (author)
-
Wareham, N J (author)
-
Sotoodehnia, N (author)
-
Ong, K K (author)
-
van Meurs, J B J (author)
-
Conneely, K N (author)
-
Baccarelli, A A (author)
-
Deary, I J (author)
-
Bell, J T (author)
-
North, K E (author)
-
Liu, Y (author)
-
Waldenberger, M (author)
-
London, S J (author)
-
- Ingelsson, Erik, 1975- (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA
-
Levy, D (author)
-
show less...
-
(creator_code:org_t)
- 2016-11-15
- 2018
- English.
-
In: Molecular Psychiatry. - : Springer Science and Business Media LLC. - 1359-4184 .- 1476-5578. ; 23, s. 422-433
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://uu.diva-port... (primary) (Raw object)
-
https://www.nature.c...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- The lack of reliable measures of alcohol intake is a major obstacle to the diagnosis and treatment of alcohol-related diseases. Epigenetic modifications such as DNA methylation may provide novel biomarkers of alcohol use. To examine this possibility, we performed an epigenome-wide association study of methylation of cytosine-phosphate-guanine dinucleotide (CpG) sites in relation to alcohol intake in 13 population-based cohorts (ntotal=13 317; 54% women; mean age across cohorts 42-76 years) using whole blood (9643 European and 2423 African ancestries) or monocyte-derived DNA (588 European, 263 African and 400 Hispanic ancestry) samples. We performed meta-analysis and variable selection in whole-blood samples of people of European ancestry (n=6926) and identified 144 CpGs that provided substantial discrimination (area under the curve=0.90-0.99) for current heavy alcohol intake (⩾42 g per day in men and ⩾28 g per day in women) in four replication cohorts. The ancestry-stratified meta-analysis in whole blood identified 328 (9643 European ancestry samples) and 165 (2423 African ancestry samples) alcohol-related CpGs at Bonferroni-adjusted P<1 × 10(-7). Analysis of the monocyte-derived DNA (n=1251) identified 62 alcohol-related CpGs at P<1 × 10(-7). In whole-blood samples of people of European ancestry, we detected differential methylation in two neurotransmitter receptor genes, the γ-Aminobutyric acid-A receptor delta and γ-aminobutyric acid B receptor subunit 1; their differential methylation was associated with expression levels of a number of genes involved in immune function. In conclusion, we have identified a robust alcohol-related DNA methylation signature and shown the potential utility of DNA methylation as a clinically useful diagnostic test to detect current heavy alcohol consumption.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Andra medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Other Basic Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Liu, C
-
Marioni, R E
-
Hedman, Åsa K
-
Pfeiffer, L
-
Tsai, P-C
-
Reynolds, L M
-
show more...
-
Just, A C
-
Duan, Q
-
Boer, C G
-
Tanaka, T
-
Elks, C E
-
Aslibekyan, S
-
Brody, J A
-
Kühnel, B
-
Herder, C
-
Almli, L M
-
Zhi, D
-
Wang, Y
-
Huan, T
-
Yao, C
-
Mendelson, M M
-
Joehanes, R
-
Liang, L
-
Love, S-A
-
Guan, W
-
Shah, S
-
McRae, A F
-
Kretschmer, A
-
Prokisch, H
-
Strauch, K
-
Peters, A
-
Visscher, P M
-
Wray, N R
-
Guo, X
-
Wiggins, K L
-
Smith, A K
-
Binder, E B
-
Ressler, K J
-
Irvin, M R
-
Absher, D M
-
Hernandez, D
-
Ferrucci, L
-
Bandinelli, S
-
Lohman, K
-
Ding, J
-
Trevisi, L
-
Gustafsson, Stef ...
-
Sandling, Johann ...
-
Stolk, L
-
Uitterlinden, A ...
-
Yet, I
-
Castillo-Fernand ...
-
Spector, T D
-
Schwartz, J D
-
Vokonas, P
-
Lind, Lars
-
Li, Y
-
Fornage, M
-
Arnett, D K
-
Wareham, N J
-
Sotoodehnia, N
-
Ong, K K
-
van Meurs, J B J
-
Conneely, K N
-
Baccarelli, A A
-
Deary, I J
-
Bell, J T
-
North, K E
-
Liu, Y
-
Waldenberger, M
-
London, S J
-
Ingelsson, Erik, ...
-
Levy, D
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Other Basic Medi ...
- Articles in the publication
-
Molecular Psychi ...
- By the university
-
Uppsala University