SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Gunnarsdottir Anna)
 

Search: WFRF:(Gunnarsdottir Anna) > Epidemiological Stu...

  • Gunnarsdóttir, Jóhanna,1978-Uppsala universitet,Obstetrik & gynekologi (author)

Epidemiological Studies of Preeclampsia : Maternal & Offspring Perspectives 

  • BookEnglish2017

Publisher, publication year, extent ...

  • Uppsala :Acta Universitatis Upsaliensis,2017
  • 69 s.
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-320138
  • ISBN:9789155499204
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-320138URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:vet swepub-contenttype
  • Subject category:dok swepub-publicationtype

Series

  • Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine,1651-6206 ;1333

Notes

  • Preeclampsia is a placental-related disorder characterized by generalized endothelial activation. Vascular predisposition is associated with the occurrence of preeclampsia and the recurrence risk is substantial. Onset of preeclampsia is preceded by placental hypo-perfusion, and placental over-production of vasoconstrictive agents might explain symptoms such as hypertension and proteinuria. Preeclampsia is associated with the birth of small-for-gestational-age (SGA) infants. The trajectory of postnatal growth in SGA-born children is described as catch-up, but it is unclear whether prenatal preeclampsia is independently associated with postnatal growth.The objectives were: firstly, to study the association between partner change and prior miscarriages on the occurrence of preeclampsia and SGA; secondly, to study postnatal growth in children prenatally exposed to preeclampsia; and thirdly, to address the association between blood pressure (BP) changes during pregnancy and risks of preeclampsia and SGA.Population-based cohort studies were performed with information from the following registers: Swedish Medical Birth Register, Uppsala Mother and Child Database and Stockholm-Gotland Obstetric Database. Associations were estimated with logistic and linear regression analyses, with adjustments for maternal characteristics, including body mass index, pre-gestational diseases and socioeconomic factors.The results were, firstly, that partner change was associated with preeclampsia and SGA birth in the second pregnancy but depended on the outcome of the first pregnancy, and that a history of recurrent miscarriages was associated with increased risks of preeclampsia and SGA. Secondly, prenatal exposure to preeclampsia was associated with increased offspring growth in height during the first five years. This association was also seen in children born with normal birth weight for gestational age. Thirdly, pre-hypertension in late gestation and elevated diastolic BP from early to mid-gestation were both associated with SGA birth. Further, women with pre-hypertension in early gestation without lowered diastolic BP until mid-gestation seemed to represent a risk group for preeclampsia.To conclude, the importance of previous pregnancy outcomes in the antenatal risk evaluation was highlighted. Secondly, the results imply that postnatal growth trajectory is related to maternal preeclampsia, in addition to SGA. Thirdly, the association between BP changes within a normal range and SGA may challenge the clinical cut-off for hypertension in pregnancy.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Wikström, Anna-KarinUppsala universitet,Institutionen för kvinnors och barns hälsa,Department of Clinical Sciences, Danderyds sjukhus, Karolinska Institutet (thesis advisor)
  • Cnattingius, Sven,senior ProfessorClinical Epidemiology Unit, Department of Medicine Solna, Karolinska University Hospital, and Institutet (thesis advisor)
  • Högberg, Ulf,senior ProfessorUppsala universitet,Institutionen för kvinnors och barns hälsa (thesis advisor)
  • Smárason, Alexander,ProfessorInstitution of Health Science Research, University of Akureyri Department of Obstetrics and Gynaecology, Akureyri Hospital (opponent)
  • Uppsala universitetObstetrik & gynekologi (creator_code:org_t)

Internet link

Find in a library

To the university's database

Search outside SwePub

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view